2023
Estradiol cycling drives female obesogenic adipocyte hyperplasia
del M. Saavedra-Peña R, Taylor N, Flannery C, Rodeheffer M. Estradiol cycling drives female obesogenic adipocyte hyperplasia. Cell Reports 2023, 42: 112390. PMID: 37053070, PMCID: PMC10567995, DOI: 10.1016/j.celrep.2023.112390.Peer-Reviewed Original ResearchConceptsAdipocyte precursor cellsHigh-fat dietAdipocyte hyperplasiaHFD feedingVisceral WATDifferential fat distributionAdipose tissue distributionEstrogen receptor αWAT distributionFat distributionOvariectomized femalesHyperplasiaMice showEstrous cycleReceptor αTissue distributionPrecursor cellsObesityAPC proliferationTissue microenvironmentProliferationFemalesSexOnsetFeeding
2012
Polycystic ovary syndrome in adolescence: impaired glucose tolerance occurs across the spectrum of BMI
Flannery CA, Rackow B, Cong X, Duran E, Selen DJ, Burgert TS. Polycystic ovary syndrome in adolescence: impaired glucose tolerance occurs across the spectrum of BMI. Pediatric Diabetes 2012, 14: 42-49. PMID: 22925367, PMCID: PMC4864958, DOI: 10.1111/j.1399-5448.2012.00902.x.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testingPolycystic ovary syndromeAbnormal glucose metabolismGlucose metabolismOB cohortOvary syndromeGlucose toleranceAndrogen Excess Society criteriaHomeostatic model assessmentPresence of obesityGlucose tolerance testingC-reactive proteinType 2 diabetesNon-obese adolescentsHigh-density lipoproteinInsulin levelsInsulin resistanceSubgroup analysisChronic conditionsMetabolic manifestationsReproductive yearsSociety criteriaLipid profileTolerance testingTestosterone levels