2020
Racial disparities in surgical outcomes for benign thyroid disease
Maduka RC, Gibson CE, Chiu AS, Jean RA, Wills-Johnson N, Azar SA, Oliveira K, Ahuja V. Racial disparities in surgical outcomes for benign thyroid disease. The American Journal Of Surgery 2020, 220: 1219-1224. PMID: 32669203, DOI: 10.1016/j.amjsurg.2020.06.054.Peer-Reviewed Original ResearchConceptsBenign thyroid diseaseThyroid diseaseRLN injuryNeck hematomaPostoperative complicationsWhite patientsSurgical outcomesRacial disparitiesRecurrent laryngeal nerve injuryLaryngeal nerve injurySignificant postoperative complicationsMalignant thyroid diseaseSignificant hypocalcemiaNerve injuryPostoperative outcomesPatient factorsSurgical treatmentBlack patientsAsian patientsBenign diseaseThyroid surgeryHigh incidenceGreater oddsPatientsMultivariate analysisThe Unintended Consequences of Nonoperative Management of Acute Appendicitis
Oliveira K, Jean RA, Gonsai R, Maduka RC, Gibson CE, Chiu AS, Ahuja V. The Unintended Consequences of Nonoperative Management of Acute Appendicitis. Journal Of Surgical Research 2020, 255: 436-441. PMID: 32619858, DOI: 10.1016/j.jss.2020.05.018.Peer-Reviewed Original ResearchConceptsNonoperative managementAcute appendicitisNational Readmission DatabaseOdds of readmissionCause readmission rateRisk of readmissionTraditional operative approachMultivariable linear regressionMore comorbiditiesIndex hospitalizationReadmission ratesSurgical managementAdult admissionsOperative approachPatient burdenAppendicitisPatientsSix monthsAppendectomyReadmissionSignificant increaseMost casesLinear regressionManagementComorbidities
2017
Identification of distinct cytomorphologic features in the diagnosis of NIFTP at the time of preoperative FNA: Implications for patient management
Chandler JB, Colunga M, Prasad ML, Callender GG, Quinn C, Chhieng D, Adeniran AJ. Identification of distinct cytomorphologic features in the diagnosis of NIFTP at the time of preoperative FNA: Implications for patient management. Cancer Cytopathology 2017, 125: 865-875. PMID: 28834409, DOI: 10.1002/cncy.21910.Peer-Reviewed Original ResearchConceptsFine-needle aspirationPapillary thyroid carcinomaFollicular variantNIFTP casesFVPTC casesCytomorphologic featuresInvasive counterpartsThyroid carcinomaExact testPapillary thyroid carcinoma (FVPTC) subtypesMicrofollicular patternDistinct cytomorphologic featuresPreoperative cytologic evaluationPreoperative fine-needle aspirationOnly independent predictorPapillary-like nuclear featuresDiagnosis of FVPTCNoninvasive follicular thyroid neoplasmFisher's exact testFollicular thyroid neoplasmCases of NIFTPFVPTC subtypesNIFTP diagnosisIndolent natureIndependent predictors
2016
Parathyroidectomy prior to kidney transplant decreases graft failure
Callender GG, Malinowski J, Javid M, Zhang Y, Huang H, Quinn CE, Carling T, Tomlin R, Smith JD, Kulkarni S. Parathyroidectomy prior to kidney transplant decreases graft failure. Surgery 2016, 161: 44-50. PMID: 27863776, DOI: 10.1016/j.surg.2016.10.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCohort StudiesConfidence IntervalsDatabases, FactualFemaleGraft RejectionGraft SurvivalHumansHyperparathyroidismKidney Failure, ChronicKidney TransplantationMaleMiddle AgedOdds RatioParathyroid HormoneParathyroidectomyPreoperative CareRetrospective StudiesRisk AssessmentTreatment OutcomeConceptsYear post-kidney transplantationPost-kidney transplantationDelayed graft functionGraft failureKidney transplantationGraft functionParathyroid hormoneUremic hyperparathyroidismKidney diseaseFirst year post-kidney transplantationSerum parathyroid hormone levelsCurrent Kidney DiseaseGlobal Outcomes (KDIGO) guidelinesParathyroid hormone levelsSerum parathyroid hormoneAdult patientsKidney transplantOutcomes guidelinesRetrospective reviewSingle institutionCurrent guidelinesHormone levelsSurvival 1ParathyroidectomyTransplantationPrimary hyperparathyroidism with normal baseline intraoperative parathyroid hormone: A challenging population
Javid M, Callender G, Quinn C, Carling T, Donovan P, Udelsman R. Primary hyperparathyroidism with normal baseline intraoperative parathyroid hormone: A challenging population. Surgery 2016, 161: 493-498. PMID: 27712879, DOI: 10.1016/j.surg.2016.08.018.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAge FactorsAgedAged, 80 and overAlgorithmsCohort StudiesFemaleFollow-Up StudiesHumansHyperparathyroidism, PrimaryMaleMiddle AgedMonitoring, IntraoperativeParathyroid HormoneParathyroidectomyPredictive Value of TestsReference ValuesRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex FactorsTreatment OutcomeYoung AdultConceptsIntraoperative parathyroid hormonePrimary hyperparathyroidismParathyroid hormoneSurgeon's judgmentIntraoperative parathyroid hormone levelsParathyroid hormone levelsDouble adenomasMultigland hyperplasiaMultigland diseaseConsecutive patientsMedian ageOperative findingsOperative patientsSingle adenomaRetrospective reviewSingle institutionHormone levelsHigh incidenceNormal rangePatientsPredictive valuePg/HyperparathyroidismSurgical judgmentOptimal outcomesShifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma
Rubinstein JC, Brown TC, Christison-Lagay ER, Zhang Y, Kunstman JW, Juhlin CC, Nelson-Williams C, Goh G, Quinn CE, Callender GG, Udelsman R, Lifton RP, Korah R, Carling T. Shifting patterns of genomic variation in the somatic evolution of papillary thyroid carcinoma. BMC Cancer 2016, 16: 646. PMID: 27538953, PMCID: PMC4989347, DOI: 10.1186/s12885-016-2665-7.Peer-Reviewed Original ResearchConceptsSingle nucleotide substitutionSomatic evolutionCommon ancestor cellGenomic changesNucleotide substitutionsTissue typesTissue-specific signaturesGenomic divergenceGenomic variationGenomic instabilityGenomic signaturesRisk of tumorigenesisSelective pressurePTC tumorigenesisTumor genomesAncestor cellsGenomeA transversionMethodsExome sequencingDiverse mutationsSomatic eventsMutational spectrumT transitionNovel patternTumorigenesisDissection of Levels II Through V Is Required for Optimal Outcomes in Patients with Lateral Neck Lymph Node Metastasis from Papillary Thyroid Carcinoma
Javid M, Graham E, Malinowski J, Quinn CE, Carling T, Udelsman R, Callender GG. Dissection of Levels II Through V Is Required for Optimal Outcomes in Patients with Lateral Neck Lymph Node Metastasis from Papillary Thyroid Carcinoma. Journal Of The American College Of Surgeons 2016, 222: 1066-1073. PMID: 27049777, DOI: 10.1016/j.jamcollsurg.2016.02.006.Peer-Reviewed Original ResearchConceptsLateral neck dissectionPapillary thyroid carcinomaPositive lymph nodesNeck dissectionLymph node metastasisRadical neck dissectionThyroid carcinomaLevel IIInitial dissectionNerve injuryLymph nodesNode metastasisLateral neck lymph node metastasisTherapeutic lateral neck dissectionNeck lymph node metastasisRegional lymph node metastasisInitial neck dissectionLevel II diseaseTemporary nerve injuryLarge patient seriesPermanent nerve injuryIpsilateral lymphReoperative surgerySurgical resectionConsecutive patients
2015
Real-Time Super Selective Venous Sampling in Remedial Parathyroid Surgery
Lebastchi AH, Aruny JE, Donovan PI, Quinn CE, Callender GG, Carling T, Udelsman R. Real-Time Super Selective Venous Sampling in Remedial Parathyroid Surgery. Journal Of The American College Of Surgeons 2015, 220: 994-1000. PMID: 25868412, DOI: 10.1016/j.jamcollsurg.2015.01.004.Peer-Reviewed Original ResearchConceptsSuper-selective venous samplingRecurrent primary hyperparathyroidismSelective venous samplingCervical explorationPrimary hyperparathyroidismParathyroid surgeryVenous samplingTertiary academic medical centerPreoperative localization studiesPreoperative parathyroid localizationRapid parathyroid hormoneMetastatic parathyroid carcinomaAccurate preoperative localizationNoninvasive imaging studiesInterventional radiology suiteAcademic medical centerNoninvasive imaging modalityCulprit glandParathyroid localizationProspective databaseSubsequent surgerySurgical treatmentParathyroid carcinomaParathyroid hormonePreoperative localization
2014
Modern Experience with Aggressive Parathyroid Tumors in a High-Volume New England Referral Center
Quinn CE, Healy J, Lebastchi AH, Brown TC, Stein JE, Prasad ML, Callender GG, Carling T, Udelsman R. Modern Experience with Aggressive Parathyroid Tumors in a High-Volume New England Referral Center. Journal Of The American College Of Surgeons 2014, 220: 1054-1062. PMID: 25488353, DOI: 10.1016/j.jamcollsurg.2014.10.007.Peer-Reviewed Original ResearchConceptsParathyroid carcinomaAtypical adenomasReferral centerParathyroid tumorsIntact parathyroid hormone levelsTertiary academic referral centerClinicopathologic tumor characteristicsParathyroid carcinoma patientsParathyroid hormone levelsAcademic referral centerAtypical parathyroid adenomaLoss of parafibrominHypercalcemic crisisProspective databaseIntraoperative variablesPathologic variablesRare malignancySurgical treatmentCarcinoma patientsClinical presentationSerum calciumTumor characteristicsParathyroid adenomaPostoperative managementTumor size