2022
MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver
Santana J, Petukhova-Greenstein A, Gross M, Hyder F, Pekurovsky V, Gottwald L, Boustani A, Walsh J, Kucukkaya A, Malpani R, Madoff D, Goldberg S, Ahmed M, Joshi N, Coman D, Chapiro J. MR Imaging–Based In Vivo Macrophage Imaging to Monitor Immune Response after Radiofrequency Ablation of the Liver. Journal Of Vascular And Interventional Radiology 2022, 34: 395-403.e5. PMID: 36423815, PMCID: PMC11042914, DOI: 10.1016/j.jvir.2022.11.013.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsContrast MediaImmunityLiverMacrophagesMagnetic Resonance ImagingMiceMice, Inbred C57BLRadiofrequency AblationConceptsImmune responseT1-weighted MRPrussian blue stainingRadiofrequency ablationRF ablationC57BL/6 wild-type miceMR imagingDose-escalation studyLocal immune responseMass cytometryWild-type miceRadiological-pathological correlationBlue stainingT1-weighted MR imagingHepatic radiofrequency ablationCD68 antibodyUntreated lobeVivo doseHepatic RF ablationVivo macrophagesMacrophagesMiceMR imaging scannerCoagulation areaCD68Methylated tetra‐amide derivatives of paramagnetic complexes for magnetic resonance biosensing with both BIRDS and CEST
Zakaria ABM, Huang Y, Coman D, Mishra SK, Mihailovic JM, Maritim S, Rojas‐Quijano F, Jurek P, Kiefer GE, Hyder F. Methylated tetra‐amide derivatives of paramagnetic complexes for magnetic resonance biosensing with both BIRDS and CEST. NMR In Biomedicine 2022, 35: e4687. PMID: 34970801, DOI: 10.1002/nbm.4687.Peer-Reviewed Original ResearchAmidesBiosensing TechniquesChelating AgentsContrast MediaMagnetic Resonance ImagingMagnetic Resonance SpectroscopyProtons
2021
High‐resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA‐tetraglycinate agents
Mihailovic JM, Huang Y, Walsh JJ, Khan MH, Mishra SK, Samuels S, Hyder F, Coman D. High‐resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA‐tetraglycinate agents. NMR In Biomedicine 2021, 35: e4658. PMID: 34837412, DOI: 10.1002/nbm.4658.Peer-Reviewed Original ResearchImaging the transmembrane and transendothelial sodium gradients in gliomas
Khan MH, Walsh JJ, Mihailović JM, Mishra SK, Coman D, Hyder F. Imaging the transmembrane and transendothelial sodium gradients in gliomas. Scientific Reports 2021, 11: 6710. PMID: 33758290, PMCID: PMC7987982, DOI: 10.1038/s41598-021-85925-9.Peer-Reviewed Original ResearchMeSH KeywordsBiological TransportBiomarkersBlood-Brain BarrierEnergy MetabolismGliomaMagnetic Resonance ImagingSodiumSpectrum Analysis
2020
A high‐throughput imaging platform to characterize extracellular pH in organotypic three‐dimensional in vitro models of liver cancer
Savic LJ, Schobert IT, Hamm CA, Adam LC, Hyder F, Coman D. A high‐throughput imaging platform to characterize extracellular pH in organotypic three‐dimensional in vitro models of liver cancer. NMR In Biomedicine 2020, 34: e4465. PMID: 33354836, DOI: 10.1002/nbm.4465.Peer-Reviewed Original ResearchConceptsLiver cancer modelLiver cancerHepatocellular carcinomaCancer modelNon-tumorous hepatocytesUnpaired t-testCell linesDose-dependent mannerHepatocyte cell lineTreatment responseTherapy resistanceMagnetic resonance spectroscopicT MR scannerPersonalized treatmentTumor metabolismCancerTumor pHMR resultsT-testCarcinomaViability assaysExtracellular pHMR scannerANOVA testTreatmentMolecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy?
Savic LJ, Doemel LA, Schobert IT, Montgomery RR, Joshi N, Walsh JJ, Santana J, Pekurovsky V, Zhang X, Lin M, Adam L, Boustani A, Duncan J, Leng L, Bucala RJ, Goldberg SN, Hyder F, Coman D, Chapiro J. Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy? Radiology 2020, 296: 575-583. PMID: 32633675, PMCID: PMC7434651, DOI: 10.1148/radiol.2020200373.Peer-Reviewed Original ResearchConceptsImmuno-oncologic therapiesConventional transarterial chemoembolizationTransarterial chemoembolizationIntratumoral immune cell infiltrationMR spectroscopyRabbit liver tumor modelPrussian blue iron stainingAntigen-presenting immune cellsIntra-arterial infusionImmune cell infiltrationNew Zealand white rabbitsLiver tumor modelImmune cell exclusionLiver cancer modelContrast material administrationT2-weighted MRIZealand white rabbitsT2-weighted imagingResistance mechanismsImmunosuppressive tumorHLA-DRCell infiltrationImmune cellsImmunohistochemistry stainingRing enhancementMolecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment
Savic LJ, Schobert I, Peters D, Walsh JJ, Laage-Gaupp F, Hamm CA, Tritz N, Doemel LA, Lin M, Sinusas A, Schlachter T, Duncan JS, Hyder F, Coman D, Chapiro J. Molecular Imaging of Extracellular Tumor pH to Reveal Effects of Locoregional Therapy on Liver Cancer Microenvironment. Clinical Cancer Research 2020, 26: 428-438. PMID: 31582517, PMCID: PMC7244230, DOI: 10.1158/1078-0432.ccr-19-1702.Peer-Reviewed Original ResearchConceptsMR spectroscopic imagingLocoregional therapyLiver cancer microenvironmentConventional transarterial chemoembolizationNew Zealand white rabbitsTumor pHMost liver tumorsZealand white rabbitsMolecular imaging paradigmsPositive therapeutic outcomesTumor residualsTransarterial chemoembolizationTumor devascularizationHistopathologic markersViable tumorSurrogate biomarkerLiver tumorsLiver cancerTumor enhancementLiver parenchymaMetabolic markersMultiparametric MRITherapeutic outcomesHIF-1αVX2 tumors
2019
Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner
Coman D, Peters DC, Walsh JJ, Savic LJ, Huber S, Sinusas AJ, Lin M, Chapiro J, Constable RT, Rothman DL, Duncan JS, Hyder F. Extracellular pH mapping of liver cancer on a clinical 3T MRI scanner. Magnetic Resonance In Medicine 2019, 83: 1553-1564. PMID: 31691371, PMCID: PMC7244229, DOI: 10.1002/mrm.28035.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiosensing TechniquesExtracellular SpaceHydrogen-Ion ConcentrationLiver NeoplasmsMagnetic Resonance ImagingRabbitsPrognosticating brain tumor patient survival after laser thermotherapy: Comparison between neuroradiological reading and semi-quantitative analysis of MRI data
Hanna JM, Temares D, Hyder F, Rothman DL, Fulbright RK, Chiang VL, Coman D. Prognosticating brain tumor patient survival after laser thermotherapy: Comparison between neuroradiological reading and semi-quantitative analysis of MRI data. Magnetic Resonance Imaging 2019, 65: 45-54. PMID: 31675529, DOI: 10.1016/j.mri.2019.09.011.Peer-Reviewed Original Research
2017
Mapping Extracellular pH of Gliomas in Presence of Superparamagnetic Nanoparticles: Towards Imaging the Distribution of Drug‐Containing Nanoparticles and Their Curative Effect on the Tumor Microenvironment
Maritim S, Coman D, Huang Y, Rao JU, Walsh JJ, Hyder F. Mapping Extracellular pH of Gliomas in Presence of Superparamagnetic Nanoparticles: Towards Imaging the Distribution of Drug‐Containing Nanoparticles and Their Curative Effect on the Tumor Microenvironment. Contrast Media & Molecular Imaging 2017, 2017: 3849373. PMID: 29362558, PMCID: PMC5736903, DOI: 10.1155/2017/3849373.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsContrast MediaDrug CarriersGliomaHydrogen-Ion ConcentrationMagnetic Resonance ImagingMagnetite NanoparticlesMaleRatsRats, Inbred F344Tumor MicroenvironmentConceptsBrain microvasculatureCurative effectTherapeutic effectIntravenous injectionTherapeutic impactTumor typesD-NPsTumor microenvironmentSuperparamagnetic iron oxideTumor hallmarksGliomasDrug distributionInfusionMRI contrastHealing efficacyMRI readoutsMicrovasculatureDrugsExtracellular pHDrug-containing nanoparticlesTumor-targeted nanoparticlesSPIO NPsTumor boundariesTemozolomide arrests glioma growth and normalizes intratumoral extracellular pH
Rao JU, Coman D, Walsh JJ, Ali MM, Huang Y, Hyder F. Temozolomide arrests glioma growth and normalizes intratumoral extracellular pH. Scientific Reports 2017, 7: 7865. PMID: 28801587, PMCID: PMC5554228, DOI: 10.1038/s41598-017-07609-7.Peer-Reviewed Original ResearchConceptsU251 tumorsTumor microenvironmentT2-weighted MRITherapeutic responseUntreated ratsTumor volumeRat brainTumor growthTherapeutic influenceGlioma growthPeritumoral regionRatsApoptosis inductionTumorsGliomasTumor corePhysiological readoutsExtracellular pHAcidic pHeTumor boundariesProliferationMicroenvironment
2016
Towards longitudinal mapping of extracellular pH in gliomas
Huang Y, Coman D, Herman P, Rao JU, Maritim S, Hyder F. Towards longitudinal mapping of extracellular pH in gliomas. NMR In Biomedicine 2016, 29: 1364-1372. PMID: 27472471, PMCID: PMC5035200, DOI: 10.1002/nbm.3578.Peer-Reviewed Original ResearchConceptsSurgical interventionPlasma concentrationsU87 brain tumorsPreclinical modelsRenal clearanceSame subjectsTumor assessmentBrain tumorsProbe doseTherapeutic monitoringTranslational valueTumor characterizationLongitudinal scansChemical shift imaging techniqueThulium ionsMolecular imagingParamagnetic probesInterventionScansImaging techniquesSubjectsNon-exchangeable protonsChapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRI
Shu CY, Sanganahalli BG, Coman D, Herman P, Hyder F. Chapter 5 New horizons in neurometabolic and neurovascular coupling from calibrated fMRI. Progress In Brain Research 2016, 225: 99-122. PMID: 27130413, DOI: 10.1016/bs.pbr.2016.02.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainBrain MappingHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNeurotransmitter AgentsNeurovascular CouplingOxygenConceptsNeurovascular couplingFunctional MRINeuronal activityBlood oxygenation level-dependent (BOLD) signalFunctional brain activationLevel-dependent signalNeurometabolic couplingEffective therapyBlood flowNeuroimaging toolsHealth conditionsPowerful neuroimaging toolBrain activationBOLD signalNeural activityBOLD contrastMetabolic demandsOxygen consumptionDependent signalsTherapyMicrovesselsMRIActivityBiomarkersImaging the intratumoral–peritumoral extracellular pH gradient of gliomas
Coman D, Huang Y, Rao JU, De Feyter HM, Rothman DL, Juchem C, Hyder F. Imaging the intratumoral–peritumoral extracellular pH gradient of gliomas. NMR In Biomedicine 2016, 29: 309-319. PMID: 26752688, PMCID: PMC4769673, DOI: 10.1002/nbm.3466.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiosensing TechniquesBrain NeoplasmsCell Line, TumorExtracellular SpaceGliomaHydrogen-Ion ConcentrationImmunohistochemistryMagnetic Resonance ImagingMaleRats, Inbred F344ConceptsRG2 tumorsTumor typesKi-67-positive cellsCancer therapeutic responseAcidic pHeTherapeutic responseRat brainPositive cellsSolid tumorsTumor cell invasionTumor borderTumorsPeritumoral regionNormal tissuesCell invasionTumor pHeP-MRSCancer imagingNeutral intracellularImagingPreclinical applicationsInfusionTherapy
2014
Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance
Strohbehn G, Coman D, Han L, Ragheb RR, Fahmy TM, Huttner AJ, Hyder F, Piepmeier JM, Saltzman WM, Zhou J. Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance. Journal Of Neuro-Oncology 2014, 121: 441-449. PMID: 25403507, PMCID: PMC4323763, DOI: 10.1007/s11060-014-1658-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBrain NeoplasmsConvectionDrug Delivery SystemsFerric CompoundsGlioblastomaHumansImage Processing, Computer-AssistedLactic AcidMagnetic Resonance ImagingNanoparticlesNeuroimagingPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRatsRats, Sprague-DawleyConceptsBrain-penetrating nanoparticlesSuperparamagnetic iron oxideEfficient deliveryDrug-loaded nanoparticlesDistribution of nanoparticlesTransverse relaxivityPLGA nanoparticlesNanoparticlesConvection-enhanced deliveryDelivery platformFuture clinical applicationsUniversal tumor recurrenceClinical translationSignal attenuationDetection modalitiesIron oxideSame morphologyParticle distributionDeliveryGroundbreaking approachClinical applicationRelevant volumesRelaxivityTreatment of GBMOxideCharacterization of a lanthanide complex encapsulated with MRI contrast agents into liposomes for biosensor imaging of redundant deviation in shifts (BIRDS)
Maritim S, Huang Y, Coman D, Hyder F. Characterization of a lanthanide complex encapsulated with MRI contrast agents into liposomes for biosensor imaging of redundant deviation in shifts (BIRDS). JBIC Journal Of Biological Inorganic Chemistry 2014, 19: 1385-1398. PMID: 25304046, PMCID: PMC4348029, DOI: 10.1007/s00775-014-1200-z.Peer-Reviewed Original ResearchMeSH KeywordsBiosensing TechniquesContrast MediaCoordination ComplexesLanthanoid Series ElementsLiposomesMagnetic Resonance ImagingMolecular ImagingMolecular StructureConceptsLanthanide complexesMagnetic resonance imaging (MRI) probesParamagnetic lanthanide complexesT2 contrast agentsRedundant deviationMolecular imagingMRI contrast agentsNon-exchangeable protonsContrast agentsMRI contrastChemical shiftsMRI probesLiposomal encapsulation efficiencyParamagnetic environmentSignal amplificationEncapsulation efficiencyWater relaxationProbe environmentTransverse relaxation timeParamagnetic effectImaging probeHigh spatial resolutionParamagnetic agentsParamagnetic contrast agentRelaxation time
2013
Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by 19F chemical shift imaging
Coman D, Sanganahalli BG, Cheng D, McCarthy T, Rothman DL, Hyder F. Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by 19F chemical shift imaging. Magnetic Resonance Imaging 2013, 32: 305-313. PMID: 24581725, PMCID: PMC3965601, DOI: 10.1016/j.mri.2013.10.015.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsBrainFluorodeoxyglucose F18Glucose-6-PhosphateMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMetabolic Clearance RateMolecular ImagingPhosphorylationPhosphotransferasesRadionuclide ImagingRadiopharmaceuticalsRatsRats, Inbred LewReproducibility of ResultsSensitivity and SpecificityTissue DistributionConceptsRat brainChemical shift imagingHalothane-anesthetized ratsMagnetic resonance spectroscopy studyTotal glucose metabolismMinimal side effectsMagnetic resonance imaging (MRI) measurementsFunctional magnetic resonance imaging (fMRI) measurementsFDG phosphorylationFMRI BOLD responsesCerebral physiologyForepaw stimulationShift imagingGlucose metabolismSide effectsBrain tissueFDGExtracted tissuesTumor pathophysiologyBrainMRS measurementsTissue componentsVivo detectionVivoD-glucoseIn vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution
Coman D, de Graaf R, Rothman DL, Hyder F. In vivo three‐dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution. NMR In Biomedicine 2013, 26: 1589-1595. PMID: 23881869, PMCID: PMC3800475, DOI: 10.1002/nbm.2995.Peer-Reviewed Original ResearchConceptsK-spaceNonexchanging protonsThree-dimensional molecular imagingParamagnetic lanthanide ionsRedundant deviationChemical shift imagingField of viewMolecular imaging capabilitiesMolecular imagingRapid data acquisitionProton detectionLanthanide ionsTens of minutesImaging capabilitiesMacrocyclic chelatesSpectroscopic signalsMacrocyclicCSI experimentsRelaxation timeHigh spatiotemporal resolutionParamagnetic agents
2011
Role of Ongoing, Intrinsic Activity of Neuronal Populations for Quantitative Neuroimaging of Functional Magnetic Resonance Imaging–Based Networks
Hyder F, Herman P, Sanganahalli BG, Coman D, Blumenfeld H, Rothman DL. Role of Ongoing, Intrinsic Activity of Neuronal Populations for Quantitative Neuroimaging of Functional Magnetic Resonance Imaging–Based Networks. Brain Connectivity 2011, 1: 185-193. PMID: 22433047, PMCID: PMC3621320, DOI: 10.1089/brain.2011.0032.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingEnergy/activityMagnetic resonance imagingBOLD signalNeuronal activityQuantitative neuroimagingNeuronal populationsResonance imagingBaseline BOLD signalsTotal neuronal activityBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalResting-state fMRI experimentsAnimal modelsFMRI experimentMagnetic resonance spectroscopy measurementsBrain networksBaselineNeuroimagingPrimary objectiveImagingIntrinsic activityActivityPopulationA lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA–tetraglycinate
Coman D, Kiefer GE, Rothman DL, Sherry AD, Hyder F. A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA–tetraglycinate. NMR In Biomedicine 2011, 24: 1216-1225. PMID: 22020775, PMCID: PMC3267016, DOI: 10.1002/nbm.1677.Peer-Reviewed Original ResearchMeSH KeywordsBiosensing TechniquesCoordination ComplexesEuropiumMagnetic Resonance ImagingPhantoms, ImagingTemperatureTime FactorsConceptsResponsive contrast agentsChemical exchange saturation transferMolecular imagingNonexchangeable proton resonancesMolecular imaging agentsLanthanide complexesCEST characteristicsIon complexesBiosensing propertiesBulk waterProton exchangeProton resonancesTetraacetate derivativeNonexchangeable protonsQuantitative molecular imagingRedundant deviationExchangeable sitesInner sphereSaturation transferImaging agentCEST methodComplexesIonsContrast agentsGreat potential