2014
Epstein–Barr Virus: Epidemiology and Clinical Features of Related Cancer
Hudnall S. Epstein–Barr Virus: Epidemiology and Clinical Features of Related Cancer. 2014, 25-50. DOI: 10.1007/978-1-4939-0870-7_3.Peer-Reviewed Original ResearchCell lymphomaEBV latency genesRisk of EBVEBV-positive lymphomasNK-cell lymphomasEpstein-Barr virusEndemic Burkitt lymphomaEBV gene expressionB-cell lymphomaHuman malignant tumorsImmunodeficiency-associated lymphomasApparent immunodeficiencyEBV infectionFalciparum malariaLymphoepithelial carcinomaOrgan failureClinical featuresImmunocompetent hostsLikely multifactorialSeroprevalence ratesImmunodeficient hostsMalignant tumorsSevere diseaseNasopharyngeal carcinomaBurkitt's lymphomaHuman Cancer Virology: An Historical Review
Hudnall S. Human Cancer Virology: An Historical Review. 2014, 1-6. DOI: 10.1007/978-1-4939-0870-7_1.Peer-Reviewed Original ResearchMerkel cell carcinomaCell carcinomaHepatocellular carcinomaAdult T-cell leukemia/lymphomaT-cell leukemia/lymphomaCell leukemia/lymphomaBurkitt's lymphoma tissueEpstein-Barr virusHepatitis B virusLeukemia/lymphomaHuman cancer virusesKaposi's sarcoma tissueRetrovirus HTLV-1Tumor-inducing propertiesCervical cancerHuman papillomavirusB virusHepatitis virusLymphoma tissuesHTLV-1CarcinomaSarcoma tissuesWart tissueSophisticated molecular techniquesCancer virusesEpstein–Barr Virus: Pathogenesis and Host Immune Response
Hudnall S. Epstein–Barr Virus: Pathogenesis and Host Immune Response. 2014, 7-24. DOI: 10.1007/978-1-4939-0870-7_2.Peer-Reviewed Original ResearchEpstein-Barr virusLarge double-stranded DNA genomeDouble-stranded DNA genomeInfected cellsLytic genesAnti-viral immune responsesTerminal repeat unitsCircular episomal formVirion structural componentsLinear DNA moleculesCellular S phaseLytic replicationLatent genesB cellsImmune responseRepeat unitsImmune recognitionReplication programDaughter cellsInternal repeat unitsDNA genomeGrowth signalsIcosahedral capsidTegument proteinsEBV-specific cytotoxic T cells
2012
Human herpesvirus 6 positive Reed–Sternberg cells in nodular sclerosis Hodgkin lymphoma
Siddon A, Lozovatsky L, Mohamed A, Hudnall SD. Human herpesvirus 6 positive Reed–Sternberg cells in nodular sclerosis Hodgkin lymphoma. British Journal Of Haematology 2012, 158: 635-643. PMID: 22757777, DOI: 10.1111/j.1365-2141.2012.09206.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedBlotting, WesternCell Line, TumorDNA, ViralEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHerpesvirus 6, HumanHodgkin DiseaseHumansImmunohistochemistryLymphoma, FollicularMaleMiddle AgedPolymerase Chain ReactionReed-Sternberg CellsRoseolovirus InfectionsSclerosisYoung AdultConceptsNodular sclerosis Hodgkin lymphomaNodular sclerosis HLHHV-6 DNAEpstein-Barr virusHHV-6Hodgkin's lymphomaReed-Sternberg cellsPolymerase chain reactionRS cellsNSHL casesEBV-negative diseaseReactive lymphoid hyperplasiaClassical Hodgkin lymphomaBi-modal age distributionHHV-6 genomeYounger patientsInfectious etiologyLymphoid hyperplasiaPCR positivityYounger ageImmunohistochemistryMost casesConflicting resultsChain reactionCD30
2008
Herpesvirus prevalence and viral load in healthy blood donors by quantitative real‐time polymerase chain reaction
Hudnall SD, Chen T, Allison P, Tyring SK, Heath A. Herpesvirus prevalence and viral load in healthy blood donors by quantitative real‐time polymerase chain reaction. Transfusion 2008, 48: 1180-1187. PMID: 18422852, DOI: 10.1111/j.1537-2995.2008.01685.x.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusVaricella-zoster virusHealthy adult blood donorsAdult blood donorsBlood donorsHHV-6Human herpesvirusesViral loadHHV-7Primary infectionDonor samplesMedian viral loadHHV-6 DNAHealthy blood donorsHHV-8 DNAViral DNA loadReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionHerpes simplex virus 1Single-donor samplesSimplex virus 1Polymerase chain reaction assaysReal-time polymerase chain reaction assaysTransfusion recipientsActive infection
2005
Distribution and phenotype of Epstein–Barr virus-infected cells in human pharyngeal tonsils
Hudnall SD, Ge Y, Wei L, Yang NP, Wang HQ, Chen T. Distribution and phenotype of Epstein–Barr virus-infected cells in human pharyngeal tonsils. Modern Pathology 2005, 18: 519-527. PMID: 15696119, DOI: 10.1038/modpathol.3800369.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntigens, CDB-LymphocytesChildChild, PreschoolEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensFemaleGene Expression Regulation, ViralHerpesvirus 4, HumanHumansImmunohistochemistryImmunophenotypingMaleMiddle AgedPalatine TonsilT-LymphocytesViral Matrix ProteinsViral ProteinsConceptsEpstein-Barr virusEBER-positive cellsT cellsHuman tonsilsNK cellsPlasma cellsEpithelial cellsB cellsBiology of EBVNK/T-cell lymphomaEpstein-Barr virus-infected cellsEBV latent protein EBNA1CD20-positive B cellsCD3-positive T cellsEarly Protein BZLF1Non-B cell typeNatural killer cellsRare T cellsT-cell lymphomaLMP1-positive cellsVirus-infected cellsMost tonsilsPlasmacytoid morphologyKiller cellsInterfollicular zones
1992
Fulminant Epstein‐Barr virus‐associated post‐transplant lymphoproliferative disorders following OKT3 therapy
Canfield C, Hudnall S, Colonna J, Busuttil R, Wilkinson A, Danovitch G, Shaked A, Goldstein L, Rosenthal J. Fulminant Epstein‐Barr virus‐associated post‐transplant lymphoproliferative disorders following OKT3 therapy. Clinical Transplantation 1992, 6: 1-9. DOI: 10.1111/j.1399-0012.1992.tb00580.x.Peer-Reviewed Original ResearchPost-transplant lymphoproliferative disorderLymphoproliferative disordersEpstein-Barr virus-associated post-transplant lymphoproliferative disorderAssociated with Epstein-Barr virusOKT3 monoclonal antibody therapySequelae of immunosuppressionWithdrawal of immunosuppressionMonoclonal antibody therapyPeripheral blood smearEpstein-Barr virusOKT3 therapyAtypical lymphocytesMalignant lymphomaAntibody therapyClinical spectrumProphylactic useImmunosuppressionOKT3Medical CenterBlood smearsAcyclovirTherapyDisordersLymphomaLymphocytes
1991
Cyclosporin A renders target cells resistant to immune cytolysis
Hudnall S. Cyclosporin A renders target cells resistant to immune cytolysis. European Journal Of Immunology 1991, 21: 221-226. PMID: 1846819, DOI: 10.1002/eji.1830210133.Peer-Reviewed Original ResearchConceptsCsA dose reductionB-cell hyperplasiaB lymphocytesDose reductionCell growth inhibitionNatural killerCell hyperplasiaEarly post-transplant lymphoproliferative disordersHuman organ transplant recipientsPost-transplant lymphoproliferative disorderT cell-dependent responsesAntibody-dependent responsesPost-transplant settingOrgan transplant recipientsTarget cellsEpstein-Barr virusCell-dependent responsesHuman target cellsComplement-mediated cytolysisGrowth inhibitionTransplant recipientsDisease regressionImmune controlNK cellsLymphoproliferative disorders
1987
B‐cell lymphoma in severe combined immunodeficiency not associated with the Epstein–Barr virus
Garcia C, Brown N, Schreck R, Stiehm E, Hudnall S. B‐cell lymphoma in severe combined immunodeficiency not associated with the Epstein–Barr virus. Cancer 1987, 60: 2941-2947. PMID: 2824020, DOI: 10.1002/1097-0142(19871215)60:12<2941::aid-cncr2820601216>3.0.co;2-a.Peer-Reviewed Original ResearchConceptsEpstein-Barr virus nuclear antigenB-cell lymphomaB-cell lymphoproliferative disordersEBV DNASevere combined immunodeficiencyLymphoproliferative disordersMalignant B-cell lymphomaEBV DNA probePrevention of EBVImmunoglobulin heavy chain gene rearrangementB-cell lymphoproliferationEpstein-Barr virusClonal B-cell lymphomaGene rearrangementsHeavy chain gene rearrangementClonal Ig gene rearrangementsChain gene rearrangementAntiviral chemoprophylaxisTransplant patientsSuch prophylaxisImmunodeficient patientsTumor cell DNAAnticomplement immunofluorescenceSitu cytohybridizationPatientsRole of CD8+ and CD8- Cytolytic Effectors in IL2 Reversal of Cyclosporin-Inhibited EBV-B-Cell Cytotoxicity
Hudnall S, Kurbe M. Role of CD8+ and CD8- Cytolytic Effectors in IL2 Reversal of Cyclosporin-Inhibited EBV-B-Cell Cytotoxicity. Experimental Biology And Medicine 1987, 513-515. DOI: 10.1007/978-1-4612-4590-2_110.Peer-Reviewed Original ResearchEpstein-Barr virusPeripheral blood mononuclear cellsRecombinant interleukin-2Interleukin-2B cellsAutologous Epstein-Barr virusB95-8 Epstein-Barr virusRole of CD8NK cell cytotoxicityOrgan transplant recipientsBlood mononuclear cellsForm of cytotoxicityReactivation infectionTransplant recipientsSuppressor/Effector phenotypeMalignant lymphomaCytolytic effectorsMononuclear cellsT cellsCell cytotoxicityCyclosporin ADrug cyclosporin ACsACytotoxicity