2023
42036 The Effectiveness of a Handheld Elastic Scattering Spectroscopy (ESS) Device in Detecting Melanoma and Non-Melanoma Skin Cancers
Chatha K, Christman H, Thames T, Geisse J, Rabinovitz H, Leffell D, Grant-Kels J. 42036 The Effectiveness of a Handheld Elastic Scattering Spectroscopy (ESS) Device in Detecting Melanoma and Non-Melanoma Skin Cancers. Journal Of The American Academy Of Dermatology 2023, 89: ab233. DOI: 10.1016/j.jaad.2023.07.934.Peer-Reviewed Original Research
2022
Artificial intelligence in the detection of skin cancer
Beltrami E, Brown A, Salmon P, Leffell D, Ko J, Grant-Kels J. Artificial intelligence in the detection of skin cancer. Journal Of The American Academy Of Dermatology 2022, 87: 1336-1342. PMID: 35998842, DOI: 10.1016/j.jaad.2022.08.028.Peer-Reviewed Original ResearchConceptsArtificial intelligenceReduce health care costsSkin cancerHealth care costsImprove quality of lifeReducing physician concernsLimitations of AIQuality of lifeReducing unnecessary proceduresManagement of skin cancerDetection of skin cancerAI capabilitiesSkin cancer detectionPatient careSkin assessmentCare costsPhysician concernsAI technologyImprove qualityPromote greater accessUnnecessary proceduresClinical settingFundamental terminologyCancerCancer detection
2019
Optical Spectroscopy as a Method for Skin Cancer Risk Assessment
Rodriguez‐Diaz E, Manolakos D, Christman H, Bonning MA, Geisse JK, A'Amar OM, Leffell DJ, Bigio IJ. Optical Spectroscopy as a Method for Skin Cancer Risk Assessment. Photochemistry And Photobiology 2019, 95: 1441-1445. PMID: 31287160, DOI: 10.1111/php.13140.Peer-Reviewed Original Research
2015
Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype
Berlin NL, Cartmel B, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype. Cancer Epidemiology 2015, 39: 1078-1083. PMID: 26381319, PMCID: PMC4679454, DOI: 10.1016/j.canep.2015.09.005.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaBasal cell carcinomaFamily historySkin cancerAge of onsetLifestyle factorsBenign skin conditionsStrong risk factorFirst-degree relativesMC1R genotypeCell carcinomaRisk factorsAge 40High riskLifestyle characteristicsAge 50Particular malignancySkin conditionsBCC casesCancerGenetic susceptibilitySaliva samplesMultivariate modelIndividual riskAffected relatives
2014
Point of care cutaneous imaging technology in melanoma screening and mole mapping
Higgins HW, Lee KC, Leffell DJ. Point of care cutaneous imaging technology in melanoma screening and mole mapping. Faculty Reviews 2014, 6: 34. PMID: 24860656, PMCID: PMC4017910, DOI: 10.12703/p6-34.Peer-Reviewed Original ResearchDiagnosis of melanomaSkin cancer-related deathsRoutine skin cancer screeningMalignancy of melanocytesCancer-related deathIncidence of melanomaSkin cancer screeningCancer screeningEarly diagnosisSkin cancerMelanomaMelanoma screeningPigment-producing cellsDiagnostic discriminationEarly detectionDiagnosisHandheld magnifiersScreeningMorbidityMalignancyCancerGreater numberMortalityIncidencePhysicians
2011
Host Phenotype Characteristics and MC1R in Relation to Early-Onset Basal Cell Carcinoma
Ferrucci LM, Cartmel B, Molinaro AM, Gordon PB, Leffell DJ, Bale AE, Mayne ST. Host Phenotype Characteristics and MC1R in Relation to Early-Onset Basal Cell Carcinoma. Journal Of Investigative Dermatology 2011, 132: 1272-1279. PMID: 22158557, PMCID: PMC3305835, DOI: 10.1038/jid.2011.402.Peer-Reviewed Original ResearchConceptsDermatopathology databaseSkin reactionsCase statusBasal cell carcinoma incidenceMelanocortin 1 receptor gene variantsNon-synonymous variantsBenign skin conditionsBasal cell carcinomaReceptor gene variantsCarcinoma incidenceCell carcinomaBCC riskEpidemiologic studiesSelf-reported phenotypesLower riskSkin conditionsBCC casesSkin cancerOlder populationYoung individualsGene variantsPhenotype-genotype interactionsHost characteristicsPhenotype characteristicSkin color
2007
Management of nonmelanoma skin cancer in 2007
Neville JA, Welch E, Leffell DJ. Management of nonmelanoma skin cancer in 2007. Nature Reviews Clinical Oncology 2007, 4: 462-469. PMID: 17657251, DOI: 10.1038/ncponc0883.Peer-Reviewed Original ResearchConceptsNonmelanoma skin cancerSkin cancerNew noninvasive treatmentImmune response modifiersMohs micrographic surgeryTopical chemotherapeuticsSelect tumorsHistological patternMicrographic surgerySurgical methodsConventional excisionNoninvasive optionNoninvasive treatmentTumor typesSurgeryCancerPhotodynamic therapyTreatmentCurettageMorbidityElectrodesiccationTherapyTumorsExcisionRetinoids
2005
PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer
Asplund A, Gustafsson AC, Wikonkal NM, Sela A, Leffell DJ, Kidd K, Lundeberg J, Brash DE, Pontén F. PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer. British Journal Of Dermatology 2005, 152: 868-873. PMID: 15888139, DOI: 10.1111/j.1365-2133.2005.06464.x.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Basal CellCarcinoma, Squamous CellCodonGenetic Predisposition to DiseaseGenotypeHair ColorHumansLoss of HeterozygosityNeoplasm ProteinsPatched ReceptorsPatched-1 ReceptorPilot ProjectsPolymerase Chain ReactionPolymorphism, Single NucleotideReceptors, Cell SurfaceSkin NeoplasmsSkin PigmentationConceptsPro/Pro genotypeNonmelanoma skin cancerBasal cell carcinomaPTCH tumor suppressor geneSquamous cell carcinomaAllele frequency variationAllelic loss studiesTumor suppressor genePro genotypeSingle nucleotide polymorphismsAllelic lossGenomic DNANonrandom lossSuppressor geneCell carcinomaSwedish patientsEpithelial cell cancersLight pigmentationSkin cancerNucleotide polymorphismsMultiple basal cell carcinomasPro/LeuHuman populationPTCH geneAllele frequencies
2002
Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery
CARUCCI J, KOLENIK S, LEFFELL D. Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery. Dermatologic Surgery 2002, 28: 340-343. DOI: 10.1097/00042728-200204000-00008.Peer-Reviewed Original ResearchHuman cadaveric allograftMohs micrographic surgeryBasal cell carcinomaCadaveric allograftsCell carcinomaMicrographic surgeryHealing timeSkin cancerInfiltrative basal cell carcinomaNasal defectsAverage healing timeWound infectionHypergranulation tissueCancer histologyImmediate reconstructionResults FiveMedical statusPatientsExtensive proceduresUseful alternativeAllograftsSurgeryCarcinomaCosmesisCancerHuman Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery
Carucci JA, Kolenik SA, Leffell DJ. Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery. Dermatologic Surgery 2002, 28: 340-343. PMID: 11966793, DOI: 10.1046/j.1524-4725.2002.01143.x.Peer-Reviewed Original ResearchConceptsHuman cadaveric allograftMohs micrographic surgeryBasal cell carcinomaCadaveric allograftsCell carcinomaMicrographic surgeryHealing timeSkin cancerInfiltrative basal cell carcinomaNasal defectsAverage healing timeWound infectionHypergranulation tissueCancer histologyImmediate reconstructionMedical statusPatientsExtensive proceduresUseful alternativeAllograftsSurgeryCarcinomaCosmesisCancerDefect size
1993
Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.
Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 4216-4220. PMID: 8483937, PMCID: PMC46477, DOI: 10.1073/pnas.90.9.4216.Peer-Reviewed Original ResearchConceptsBasal cell carcinomaCell carcinomaSkin cancerPercent of tumorsSquamous cell carcinomaNonmelanoma skin cancerP53 tumor suppressor geneDipyrimidine sitesBCC developmentMutation hotspotsCancerTumor suppressor geneP53 genePoint mutationsAllelic lossCarcinomaTwo-thirdsSuppressor geneGenetic eventsSkinP53Such mutationsMutationsCarcinogenic mutationsTumors
1991
An educational device for Mohs micrographic surgery. A three-dimensional model of basal cell carcinoma.
Leffell D. An educational device for Mohs micrographic surgery. A three-dimensional model of basal cell carcinoma. Dermatologic Surgery 1991, 17: 498-501. PMID: 2040753.Peer-Reviewed Original Research