2019
Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness
Kibbi N, Zhang Y, Leffell DJ, Christensen SR. Photodynamic therapy for cutaneous squamous cell carcinoma in situ: Impact of anatomic location, tumor diameter, and incubation time on effectiveness. Journal Of The American Academy Of Dermatology 2019, 82: 1124-1130. PMID: 31712171, DOI: 10.1016/j.jaad.2019.10.079.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAminolevulinic AcidAnalysis of VarianceBiopsy, NeedleCarcinoma in SituCarcinoma, Squamous CellCohort StudiesDisease-Free SurvivalFemaleHumansImmunohistochemistryLogistic ModelsMaleMiddle AgedMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingPhotochemotherapyPrognosisRetrospective StudiesSkin NeoplasmsSurvival AnalysisTreatment OutcomeTumor BurdenConceptsCutaneous squamous cell carcinomaALA incubation timeSquamous cell carcinomaTumor diameterALA-PDTSubsequent recurrenceCell carcinomaAnatomic locationInitial complete response ratePhotodynamic therapyCases of SCCISMultivariate analysis factorsComplete response rateMedical record reviewEffectiveness of PDTPatient demographicsClinical responseMedian timeRetrospective reviewRecord reviewRetrospective studyTreatment detailsSingle institutionEffective treatmentResponse rateSquamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease
Kibbi N, Suozzi KC, Ko CJ, Leffell DJ. Squamous Cell Carcinoma of the Lip in a Patient With Graft-Versus-Host Disease. Dermatologic Surgery 2019, Publish Ahead of Print: &na;. PMID: 31260417, DOI: 10.1097/dss.0000000000001706.Peer-Reviewed Original Research
2018
Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma
Totonchy MB, Leventhal JS, Ko CJ, Leffell DJ. Hypertrophic Lichen Planus and Well-Differentiated Squamous Cell Carcinoma. Dermatologic Surgery 2018, 44: 1466-1470. PMID: 29360655, DOI: 10.1097/dss.0000000000001465.Peer-Reviewed Original Research
2017
Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases
Ko CJ, Glusac EJ, McNiff JM, Rodic N, Leffell DJ. Squamous proliferations on the legs of women: Qualitative examination of histopathology, TP53 sequencing, and implications for diagnosis in a series of 30 cases. Journal Of The American Academy Of Dermatology 2017, 77: 1126-1132.e1. PMID: 28709693, DOI: 10.1016/j.jaad.2017.04.1119.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBase SequenceCarcinoma, Squamous CellFemaleGenes, p53HumansKeratoacanthomaLegSkin NeoplasmsConceptsSquamous cell carcinomaProminent cytologic atypiaMultiple squamous cell carcinomasCytologic atypiaSquamous proliferationTP53 mutationsDetectable TP53 mutationsLegs of womenFollicle-like structuresCell carcinomaHistopathologic findingsMultiple lesionsSCC lesionsHistopathologic analysisTP53 sequencingNumerous tumorsSmall seriesTP53 variantsClinical phenotypeKeratoacanthomaLesionsTumorsDifferent patientsAtypiaReactive phenomenon
2016
Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity
Munday WR, Leffell DJ, McNiff JM, Ko CJ. Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity. Journal Of Cutaneous Pathology 2016, 43: 759-765. PMID: 27220356, DOI: 10.1111/cup.12738.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCarcinoma, Squamous CellFemaleHumansLegMaleMiddle AgedNeoplasms, Multiple PrimarySkin NeoplasmsConceptsSquamous cell carcinomaMultiple squamous cell carcinomasCutaneous squamous cell carcinomaHistopathologic featuresCell carcinomaLower extremitiesMultiple cutaneous squamous cell carcinomasRetrospective chart reviewAmerican Joint CommitteeCancer staging criteriaDistinct clinical subtypesChart reviewPerineural invasionActinic keratosisStaging criteriaClinical subtypesMost lesionsStage IJoint CommitteeStage IIKeratoacanthomaPatientsCarcinomaTumorsSubtypes
2015
Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach
Christensen SR, McNiff JM, Cool AJ, Aasi SZ, Hanlon AM, Leffell DJ. Histopathologic assessment of depth of follicular invasion of squamous cell carcinoma (SCC) in situ (SCCis): Implications for treatment approach. Journal Of The American Academy Of Dermatology 2015, 74: 356-362. PMID: 26670714, DOI: 10.1016/j.jaad.2015.09.060.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma in SituCarcinoma, Squamous CellHair FollicleHumansMohs SurgeryNeoplasm InvasivenessRetrospective StudiesSkin NeoplasmsConceptsSquamous cell carcinomaHair follicle infundibulumFollicular invasionCell carcinomaMohs micrographic surgeryHair follicle epitheliumAdditional patientsIntraoperative pathologyOptimal therapyRetrospective reviewTreatment failureProspective evaluationSingle institutionHistopathologic assessmentMicrographic surgeryMost tumorsDeep invasionTreatment approachesPathology specimensFollicle epitheliumLower follicleSCCISSurgeryCarcinomaInvasion
2013
Intralesional interferon alfa-2b for refractory, recurrent squamous cell carcinoma of the face
Hanlon A, Kim J, Leffell DJ. Intralesional interferon alfa-2b for refractory, recurrent squamous cell carcinoma of the face. Journal Of The American Academy Of Dermatology 2013, 69: 1070-1072. PMID: 24238178, DOI: 10.1016/j.jaad.2013.02.032.Peer-Reviewed Original ResearchCutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas
Kim C, Ko CJ, Leffell DJ. Cutaneous squamous cell carcinomas of the lower extremity: A distinct subset of squamous cell carcinomas. Journal Of The American Academy Of Dermatology 2013, 70: 70-74. PMID: 24210370, DOI: 10.1016/j.jaad.2013.09.026.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCarcinoma, Basal CellCarcinoma, Squamous CellFemaleHumansLower ExtremityMaleMiddle AgedSkin NeoplasmsConceptsCutaneous squamous cell carcinomaSquamous cell carcinomaLower extremitiesCell carcinomaClinical featuresIncidence of SCCPrevalence of SCCDistinct subsetsDistinctive clinical featuresNumber of patientsBasal cell carcinomaClinical outcomesSquamous cellsBiologic behaviorSame patientGeneral populationPatientsCarcinomaStudy periodAdditional studiesDefinitive conclusionsIncidenceExtremitiesOutcomesTreatment
2010
Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature
Terushkin E, Leffell DJ, Futoryan T, Cowper S, Lazova R. Squamoid Eccrine Ductal Carcinoma: A Case Report and Review of the Literature. American Journal Of Dermatopathology 2010, 32: 287-292. PMID: 20010402, DOI: 10.1097/dad.0b013e3181b623c4.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsBiomarkers, TumorCarcinoma, Squamous CellEccrine GlandsHead and Neck NeoplasmsHumansImmunocompromised HostMaleMiddle AgedMohs SurgerySweat Gland NeoplasmsConceptsDuctal carcinomaShave biopsyEccrine ductal carcinomaInitial shave biopsySuperficial shave biopsiesMohs micrographic surgeryRare adnexal tumorTreatment guidelinesCase reportDiagnostic challengeMicrographic surgeryBiologic behaviorComplete excisionAdnexal tumorsImmunohistochemical approachBiopsyCarcinomaRare variantsTumorsDiagnostic purposesPatientsSurgeryNeoplasmsExcisionCancer
2007
Management of nonmelanoma skin cancer in 2007
Neville JA, Welch E, Leffell DJ. Management of nonmelanoma skin cancer in 2007. Nature Reviews Clinical Oncology 2007, 4: 462-469. PMID: 17657251, DOI: 10.1038/ncponc0883.Peer-Reviewed Original ResearchConceptsNonmelanoma skin cancerSkin cancerNew noninvasive treatmentImmune response modifiersMohs micrographic surgeryTopical chemotherapeuticsSelect tumorsHistological patternMicrographic surgerySurgical methodsConventional excisionNoninvasive optionNoninvasive treatmentTumor typesSurgeryCancerPhotodynamic therapyTreatmentCurettageMorbidityElectrodesiccationTherapyTumorsExcisionRetinoids
2005
Mohs micrographic surgery: established uses and emerging trends.
Pennington BE, Leffell DJ. Mohs micrographic surgery: established uses and emerging trends. Oncology 2005, 19: 1165-71; discussion 1171-2, 1175. PMID: 16255133.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaCarcinoma, Basal CellCarcinoma, Merkel CellCarcinoma, Squamous CellDermatofibrosarcomaHumansMelanomaMohs SurgeryPaget Disease, ExtramammarySkin NeoplasmsConceptsSquamous cell carcinomaBasal cell carcinomaMohs micrographic surgeryCell carcinomaMicrographic surgeryCommon cutaneous neoplasmsConventional surgical excisionExtramammary Paget's diseaseMicrocystic adnexal carcinomaMerkel cell carcinomaCutaneous neoplasmsPaget's diseaseResidual tumorSurgical excisionAdnexal carcinomaCommon cancerCutaneous tumorsSurgical techniqueDermatofibrosarcoma protuberansCarcinomaDeep marginTissue conservationSurgeryTumorsDiseasePTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer
Asplund A, Gustafsson AC, Wikonkal NM, Sela A, Leffell DJ, Kidd K, Lundeberg J, Brash DE, Pontén F. PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer. British Journal Of Dermatology 2005, 152: 868-873. PMID: 15888139, DOI: 10.1111/j.1365-2133.2005.06464.x.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Basal CellCarcinoma, Squamous CellCodonGenetic Predisposition to DiseaseGenotypeHair ColorHumansLoss of HeterozygosityNeoplasm ProteinsPatched ReceptorsPatched-1 ReceptorPilot ProjectsPolymerase Chain ReactionPolymorphism, Single NucleotideReceptors, Cell SurfaceSkin NeoplasmsSkin PigmentationConceptsPro/Pro genotypeNonmelanoma skin cancerBasal cell carcinomaPTCH tumor suppressor geneSquamous cell carcinomaAllele frequency variationAllelic loss studiesTumor suppressor genePro genotypeSingle nucleotide polymorphismsAllelic lossGenomic DNANonrandom lossSuppressor geneCell carcinomaSwedish patientsEpithelial cell cancersLight pigmentationSkin cancerNucleotide polymorphismsMultiple basal cell carcinomasPro/LeuHuman populationPTCH geneAllele frequenciesBilobed transposition flap
Aasi SZ, Leffell DJ. Bilobed transposition flap. Dermatologic Clinics 2005, 23: 55-64. PMID: 15620619, DOI: 10.1016/j.det.2004.08.004.Peer-Reviewed Original Research
2000
The scientific basis of skin cancer
Leffell D. The scientific basis of skin cancer. Journal Of The American Academy Of Dermatology 2000, 42: s18-s22. PMID: 10607352, DOI: 10.1067/mjd.2000.103340.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisCarcinoma, Squamous CellGenes, p53HumansKeratosisMutationPhotosensitivity DisordersSkin NeoplasmsUltraviolet Rays
1999
Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery.
McGovern T, Grossman D, Fitzgerald D, Glusac E, Leffell D. Status of residual tumor in patients with squamous cell carcinoma referred for Mohs micrographic surgery. JAMA Dermatology 1999, 135: 1557-9. PMID: 10606080, DOI: 10.1001/archderm.135.12.1557.Peer-Reviewed Original ResearchUse of a Lyophilized Bovine Collagen Matrix in Postoperative Wound Healing
Kolenik S, McGovern T, Leffell D. Use of a Lyophilized Bovine Collagen Matrix in Postoperative Wound Healing. Dermatologic Surgery 1999, 25: 303-307. PMID: 10417587, DOI: 10.1046/j.1524-4725.1999.08230.x.Peer-Reviewed Original ResearchConceptsMohs micrographic surgeryBovine collagen matrixMicrographic surgeryWound careControl groupWound healingMinority of patientsPostoperative wound healingSecond intention healingCollagen matrixManagement of defectsWound infectionDressing changesAdverse reactionsImmediate reconstructionAllergic reactionsComplete healingAnatomic sitesRapid wound healingSurgical defectsStudy woundsLarger studySecond intentionBiological dressingSurgery
1995
The Use of Cryopreserved Human Skin Allografts in Wound Healing following Mohs Surgery
KOLENIK S, LEFFELL D. The Use of Cryopreserved Human Skin Allografts in Wound Healing following Mohs Surgery. Dermatologic Surgery 1995, 21: 615-620. PMID: 7606373, DOI: 10.1111/j.1524-4725.1995.tb00517.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Basal CellCarcinoma, Squamous CellCryopreservationDermatologic Surgical ProceduresFemaleFollow-Up StudiesGraft RejectionGraft SurvivalGranulation TissueHumansMaleMiddle AgedMohs SurgerySkinSkin CareSkin NeoplasmsSkin TransplantationSurgical Wound InfectionTransplantation, HomologousTreatment OutcomeWound HealingConceptsHuman skin allograftsWound careSkin allograftsImmediate reconstructionMohs surgeryFull-thickness skin graftingMinority of patientsEvidence of infectionExcision of tumorSkin cancer patientsFull‐thickness cutaneous defectGranulation tissue productionFull-thickness skinCancer patientsSkin graftingReconstructive proceduresWound coverageSafe alternativeBiological dressingCutaneous defectsPatientsRapid healingWound healingHealingCare