2022
An update on ductal plate malformations and fibropolycystic diseases of the liver
Mirza H, Besse W, Somlo S, Weinreb J, Kenney B, Jain D. An update on ductal plate malformations and fibropolycystic diseases of the liver. Human Pathology 2022, 132: 102-113. PMID: 35777701, DOI: 10.1016/j.humpath.2022.06.022.Peer-Reviewed Original ResearchConceptsDuctal plate malformationLiver diseaseAdult polycystic liver diseaseAutosomal dominant polycystic kidneyFibropolycystic liver diseaseIsolated liver involvementCongenital hepatic fibrosisPolycystic liver diseaseVon Meyenburg complexesGenetic underpinningsMultiple clinical phenotypesFibropolycystic diseasePortal hypertensionCaroli's diseaseLiver involvementLiver cystsMeyenburg complexesHepatic fibrosisFibrocystic lesionsHepatocellular malignanciesCyst enlargementAbnormal organ developmentPolycystic kidneysAnimal modelsHepatocellular malignancy
2019
Clinical utility of genomic analysis in adults with idiopathic liver disease
Hakim A, Zhang X, DeLisle A, Oral EA, Dykas D, Drzewiecki K, Assis DN, Silveira M, Batisti J, Jain D, Bale A, Mistry PK, Vilarinho S. Clinical utility of genomic analysis in adults with idiopathic liver disease. Journal Of Hepatology 2019, 70: 1214-1221. PMID: 31000363, PMCID: PMC6526061, DOI: 10.1016/j.jhep.2019.01.036.Peer-Reviewed Original ResearchConceptsIdiopathic liver diseaseUnexplained liver diseaseManagement of adultsWhole-exome sequencingLiver diseaseAdult patientsUnknown etiologyHeterozygous variantsUse of WESAmelioration of dyslipidemiaDaily insulin requirementLeptin replacement therapyUtility of WESChronic liver diseaseNon-alcoholic steatohepatitisAcademic health care centerHealth care centersHomozygous pathogenic variantUnrelated adult patientsNon-oncological diseasesDisease preventive measuresInsulin requirementsLean patientsDevastating complicationLiver aminotransferasesIdentification of key challenges in liver pathology: data from a multicenter study of extramural consults
Torbenson MS, Arnold CA, Graham RP, Jain D, Kakar S, Lam-Himlin DM, Naini BV, Wu TT, Yeh M. Identification of key challenges in liver pathology: data from a multicenter study of extramural consults. Human Pathology 2019, 87: 75-82. PMID: 30857968, DOI: 10.1016/j.humpath.2019.03.001.Peer-Reviewed Original ResearchConceptsLiver pathologyEtiology of cirrhosisFatty liver diseasePrimary biliary cirrhosisDiagnosis of malignancyFocal nodular hyperplasiaLiver casesAutoimmune hepatitisHepatitic patternBiliary cirrhosisLiver diseaseMetastatic malignancyMulticenter studyHepatic adenomaNodular hyperplasiaBenign tumorsConsult serviceMalignant tumorsHepatocellular carcinomaAcademic centersSpecific diagnosisTumor pathologyTumor typesConsultant diagnosesPatient care
2017
Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response
Cai SY, Ouyang X, Chen Y, Soroka CJ, Wang J, Mennone A, Wang Y, Mehal WZ, Jain D, Boyer JL. Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response. JCI Insight 2017, 2: e90780. PMID: 28289714, PMCID: PMC5333973, DOI: 10.1172/jci.insight.90780.Peer-Reviewed Original ResearchConceptsLiver injuryInflammatory responseBile acid-induced liver injuryCholestatic liver injuryInflammatory liver injuryProinflammatory cytokine expressionCholestatic liver diseaseBile duct ligationVivo mouse modelHepatic infiltrationInflammatory injurySerum aminotransferasesLiver diseaseCholestatic patientsCytokine expressionChemokine inductionPathophysiologic concentrationsNeutrophil chemotaxisDuct ligationPathophysiologic levelsMouse modelNew therapiesInnate immunityInjuryPeriportal areas
2016
Therapeutic Challenges of Hepatic Mucormycosis in Hematologic Malignancy: A Case Report and Review of the Literature
Bernardo RM, Gurung A, Jain D, Malinis MF. Therapeutic Challenges of Hepatic Mucormycosis in Hematologic Malignancy: A Case Report and Review of the Literature. American Journal Of Case Reports 2016, 17: 484-489. PMID: 27406045, PMCID: PMC4948661, DOI: 10.12659/ajcr.898480.Peer-Reviewed Case Reports and Technical NotesConceptsDual antifungal therapyAntifungal therapyHepatic mucormycosisSurgical resectionClinical presentationCase reportLiver lesionsIsolated hepatic mucormycosisTransplant-associated infectionsMultiple liver lesionsCombination antifungal therapyAcute myeloid leukemiaHigh mortality rateOptimal antifungal therapyGastrointestinal involvementInduction chemotherapyNeutropenic feverAbdominal painLymphoproliferative disordersTherapeutic challengeHematologic malignanciesCommon siteMyeloid leukemiaTreatment strategiesGastrointestinal tract
2008
Biliary and Pancreatic Dysgenesis in Mice Harboring a Mutation in Pkhd1
Gallagher AR, Esquivel EL, Briere TS, Tian X, Mitobe M, Menezes LF, Markowitz GS, Jain D, Onuchic LF, Somlo S. Biliary and Pancreatic Dysgenesis in Mice Harboring a Mutation in Pkhd1. American Journal Of Pathology 2008, 172: 417-429. PMID: 18202188, PMCID: PMC2312372, DOI: 10.2353/ajpath.2008.070381.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBile DuctsBiliary TractBlotting, SouthernBlotting, WesternCiliaDisease Models, AnimalHumansImmunohistochemistryIn Situ HybridizationKidney Tubules, ProximalLiver DiseasesMiceMice, Mutant StrainsMutationPancreatic DiseasesPolycystic Kidney, Autosomal RecessiveReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionConceptsPolycystic kidney diseaseAutosomal recessive polycystic kidney diseaseRecessive polycystic kidney diseaseKidney diseaseMouse modelCommon bile duct dilationBile duct dilationBile duct proliferationAutosomal dominant polycystic kidney diseaseProgressive cyst formationDistal nephron segmentsDominant polycystic kidney diseaseExtrahepatic manifestationsDuct dilationBiliary tractPeriportal fibrosisDuct proliferationBile ductFibrocystic diseaseOrthologous modelPancreatic cystsProximal tubulesMice harboringSusceptibility of tissuesNephron segments
2005
Liver Biopsy
Sheela H, Seela S, Caldwell C, Boyer JL, Jain D. Liver Biopsy. Journal Of Clinical Gastroenterology 2005, 39: 603-610. PMID: 16000929, DOI: 10.1097/01.mcg.0000170742.59134.60.Peer-Reviewed Original ResearchConceptsLiver biopsyCertain clinical settingsAutoimmune hepatitisEssential diagnostic toolLiver diseasePercutaneous approachCommon disorderIntraoperative approachDisease prognosisTherapeutic strategiesBiopsySerologic diagnosisClinical settingGenetic disordersDiagnostic toolDiagnosisDisordersLaboratory testsIndicationsHepatitisContraindicationsLaparoscopicComplicationsPrognosisDisease
2000
Liver Disease in Patients with Hereditary Hemorrhagic Telangiectasia
Garcia-Tsao G, Korzenik J, Young L, Henderson K, Jain D, Byrd B, Pollak J, White R. Liver Disease in Patients with Hereditary Hemorrhagic Telangiectasia. New England Journal Of Medicine 2000, 343: 931-936. PMID: 11006369, DOI: 10.1056/nejm200009283431305.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaHigh-output heart failureHemorrhagic telangiectasiaHeart failureMedian periodPortal hypertensionLiver involvementClinical findingsBiliary diseasePulmonary capillary wedge pressureElevated alkaline phosphatase levelsHepatic sinusoidal pressureSymptomatic liver involvementTypical clinical presentationAlkaline phosphatase levelsAutosomal dominant disorderHyperdynamic circulationAngiodysplastic lesionsCardiac indexLiver transplantationVariceal bleedingWedge pressureMedical therapyRendu-OslerClinical presentation