2022
Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights
Vageli D, Doukas P, Zacharouli K, Kakanis V, Strataki M, Zioga A, Skoulakis C, Koukoulis G, Ioannou M. Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights. Head And Neck Pathology 2022, 17: 331-338. PMID: 36303015, PMCID: PMC10293497, DOI: 10.1007/s12105-022-01504-y.Peer-Reviewed Original ResearchConceptsHigh-grade epithelial dysplasiaActinic cheilitisEpithelial dysplasiaDifferential diagnosisSitu carcinomaBasement membraneEarly invasionLow-grade epithelial dysplasiaLaminin immunostainingLaminin expressionHistopathological differential diagnosisBackgroundSquamous cell carcinomaOral lesionsLip cancerCell carcinomaPrecancerous lesionsParabasal cellsPreclinical studiesNeoplastic invasionOral cavityUseful biomarkerCheilitisPatientsLSCCCarcinoma
2021
Bile reflux and hypopharyngeal cancer
Vageli DP, Doukas SG, Doukas PG, Judson BL. Bile reflux and hypopharyngeal cancer. Oncology Reports 2021, 46: 244. PMID: 34558652, PMCID: PMC8485019, DOI: 10.3892/or.2021.8195.Peer-Reviewed Original ResearchConceptsHypopharyngeal cancerAcidic bileHypopharyngeal carcinogenesisBile refluxRisk factorsGastroesophageal reflux diseaseIndependent risk factorSquamous cell cancerUpper aerodigestive tractElevated p53 expressionAnti-apoptotic effectsReflux diseaseLaryngopharyngeal refluxAerodigestive tractCell cancerGastroesophageal refluxateContribution of STAT3Neck cancerPrecancerous lesionsPremalignant changesNeoplastic changesNF-κBDNA damageP53 expressionBile acids