2022
AMACR Expression is a Potential Diagnostic Marker in Apocrine Lesions of Breast, and is Associated with High Histologic Grade and Lymph Node Metastases in Some Invasive Apocrine Breast Cancers
Lerner G, Tang H, Singh K, Golestani R, St Claire S, Humphrey P, Lannin D, Janostiak R, Harigopal M. AMACR Expression is a Potential Diagnostic Marker in Apocrine Lesions of Breast, and is Associated with High Histologic Grade and Lymph Node Metastases in Some Invasive Apocrine Breast Cancers. Clinical Breast Cancer 2022, 23: 199-210. PMID: 36577560, DOI: 10.1016/j.clbc.2022.11.012.Peer-Reviewed Original ResearchConceptsInvasive ductal carcinomaTriple-negative breast cancerHigh histologic gradeApocrine differentiationAMACR expressionEstrogen receptorApocrine DCISER-/PRHistologic gradeProgesterone receptorApocrine featuresBreast cancerHuman epidermal growth factor 2 (HER2) statusLack of ERDistant metastasis-free survivalDiagnostic markerInitial N stageLack estrogen receptorApocrine breast cancerLymph node metastasisNegative breast cancerAndrogen receptor mRNACoA racemase expressionBenign breast tissueBreast cancer cohortThe Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients
Trant A, Chagpar A, Wei W, Neumeister V, Rimm D, Stavris K, Lurie B, Frederick C, Andrejeva L, Raghu M, Killelea B, Horowitz N, Lannin D, Knill-Selby E, Sturrock T, Hofstatter E. The Effect of Black Cohosh on Ki67 expression and Tumor Volume: A Pilot Study of Ductal Carcinoma in Situ Patients. Integrative Cancer Therapies 2022, 21: 15347354221137290. PMID: 36444764, PMCID: PMC9716631, DOI: 10.1177/15347354221137290.Peer-Reviewed Original ResearchConceptsTumor volumeBlack cohoshSitu patientsDuctal carcinomaAnti-inflammatory effectsTumor cellular proliferationBreast cancer treatmentCellular proliferationWilcoxon signed-rank testDCIS patientsAdverse eventsEligible subjectsWindow trialsCore biopsyInvasive diseaseKi67 expressionSigned-rank testBreast cancerGrade 3Hormone changesPatientsQuantitative immunofluorescenceBC extractSignificant toxicityCancer treatment
2017
Association of LN Evaluation with Survival in Women Aged 70 Years or Older With Clinically Node-Negative Hormone Receptor Positive Breast Cancer
Chagpar AB, Hatzis C, Pusztai L, DiGiovanna MP, Moran M, Mougalian S, Sanft T, Evans S, Hofstatter E, Wilson LD, Lannin DR. Association of LN Evaluation with Survival in Women Aged 70 Years or Older With Clinically Node-Negative Hormone Receptor Positive Breast Cancer. Annals Of Surgical Oncology 2017, 24: 3073-3081. PMID: 28766195, DOI: 10.1245/s10434-017-5936-x.Peer-Reviewed Original ResearchConceptsBreast cancer-specific survivalLN evaluationPositive breast cancerOverall survivalBreast cancerHormone receptor-positive breast cancerWomen Aged 70 YearsReceptor-positive breast cancerLymph node evaluationCancer-specific survivalLower hazard rateLN surgeryBetter OSPatient ageSEER databasePatient selectionTumor characteristicsSEER dataPatientsNode evaluationHormone receptorsCancerSurvivalTreatment variablesNCDBRegional variation in breast cancer surgery: Results from the National Cancer Database (NCDB)
Chiu AS, Thomas P, Killelea BK, Horowitz N, Chagpar AB, Lannin DR. Regional variation in breast cancer surgery: Results from the National Cancer Database (NCDB). The American Journal Of Surgery 2017, 214: 907-913. PMID: 28736057, DOI: 10.1016/j.amjsurg.2017.07.008.Peer-Reviewed Original ResearchAre Small Breast Cancers Good because They Are Small or Small because They Are Good?
Lannin DR, Wang S. Are Small Breast Cancers Good because They Are Small or Small because They Are Good? New England Journal Of Medicine 2017, 376: 2286-91. PMID: 28591529, DOI: 10.1056/nejmsr1613680.Peer-Reviewed Original Research
2016
Characteristics and treatment of human epidermal growth factor receptor 2 positive breast cancer: 43,485 cases from the National Cancer Database treated in 2010 and 2011
Killelea BK, Chagpar AB, Horowitz NR, Lannin DR. Characteristics and treatment of human epidermal growth factor receptor 2 positive breast cancer: 43,485 cases from the National Cancer Database treated in 2010 and 2011. The American Journal Of Surgery 2016, 213: 426-432. PMID: 27769548, DOI: 10.1016/j.amjsurg.2016.05.018.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, LobularChemotherapy, AdjuvantDatabases, FactualFemaleHumansIncidenceInflammatory Breast NeoplasmsLymphatic MetastasisMaleMastectomyMastectomy, SegmentalMiddle AgedNeoplasm InvasivenessPaget's Disease, MammaryRacial GroupsReceptor, ErbB-2United StatesConceptsHER2-positive tumorsHuman epidermal growth factor receptor-2-positive breast cancerNational Cancer DatabasePositive breast cancerPositive tumorsBreast cancerCancer DatabaseHER2-negative tumorsInvasive breast cancerAmerican Cancer SocietyAsian/Pacific IslandersNon-Hispanic whitesBreast preservationPositive nodesHER2 positivityLymphovascular invasionNegative tumorsTumor sizeHER2 statusTreatment characteristicsCancer casesCancer SocietyAmerican CollegeTumorsYoung women
2004
Is breast-conserving therapy in the genetically predisposed breast cancer patient a reasonable and appropriate option?
Haffty B, Lannin D. Is breast-conserving therapy in the genetically predisposed breast cancer patient a reasonable and appropriate option? European Journal Of Cancer 2004, 40: 1105-1108. PMID: 15110872, DOI: 10.1016/j.ejca.2004.01.032.Peer-Reviewed Original Research
2001
Preoperative chemotherapy and sentinel lymphadenectomy for breast cancer
Tafra L, Verbanac K, Lannin D. Preoperative chemotherapy and sentinel lymphadenectomy for breast cancer. The American Journal Of Surgery 2001, 182: 312-315. PMID: 11720661, DOI: 10.1016/s0002-9610(01)00718-8.Peer-Reviewed Original ResearchConceptsPrior chemotherapySentinel lymphadenectomyAxillary lymph nodesBreast cancerSentinel nodesPC groupLymph nodesSuspicious axillary lymph nodesSentinel node identification rateOnly exclusion criterionPositive axillary nodesAxillary node dissectionMean tumor sizeStandard of careNon-PC groupPresence of diseaseIsosulfan blueNode dissectionPreoperative chemotherapyAxillary nodesMetastatic diseaseMost patientsPC patientsMulticenter trialTumor sizeMulticenter Trial of Sentinel Node Biopsy for Breast Cancer Using Both Technetium Sulfur Colloid and Isosulfan Blue Dye
Tafra L, Lannin D, Swanson M, Van Eyk J, Verbanac K, Chua A, Ng P, Edwards M, Halliday B, Henry C, Sommers L, Carman C, Molin M, Yurko J, Perry R, Williams A. Multicenter Trial of Sentinel Node Biopsy for Breast Cancer Using Both Technetium Sulfur Colloid and Isosulfan Blue Dye. Annals Of Surgery 2001, 233: 51-59. PMID: 11141225, PMCID: PMC1421166, DOI: 10.1097/00000658-200101000-00009.Peer-Reviewed Original ResearchConceptsSentinel node biopsyMulticenter trialTechnetium sulfur colloidNode biopsyIsosulfan blueFalse negative rateOlder patientsSulfur colloidBreast cancerComplete lymph node dissectionInexperienced surgeonsLymph node dissectionMetastatic axillary nodesIsosulfan blue dyeSingle-institution seriesSentinel node localizationBreast cancer metastasisAnalysis of tumorsFalse-negative resultsNode dissectionAxillary nodesIndependent predictorsSentinel nodesPoor success ratePatients
1998
Evidence for an Ontogenetic Basis for Circadian Coordination of Cancer Cell Proliferation
Hrushesky W, Lannin D, Haus E. Evidence for an Ontogenetic Basis for Circadian Coordination of Cancer Cell Proliferation. Journal Of The National Cancer Institute 1998, 90: 1480-1484. PMID: 9776414, DOI: 10.1093/jnci/90.19.1480.Peer-Reviewed Original ResearchInfluence of Socioeconomic and Cultural Factors on Racial Differences in Late-Stage Presentation of Breast Cancer
Lannin D, Mathews H, Mitchell J, Swanson M, Swanson F, Edwards M. Influence of Socioeconomic and Cultural Factors on Racial Differences in Late-Stage Presentation of Breast Cancer. JAMA 1998, 279: 1801-1807. PMID: 9628711, DOI: 10.1001/jama.279.22.1801.Peer-Reviewed Original ResearchConceptsBreast cancer stageBreast cancerCancer stageRacial differencesMajor health care facilitiesMultivariate logistic regression modelAfrican AmericansBreast cancer mortalityTNM stage IIICase-control studySignificant predictorsUniversity Medical CenterSocioeconomic factorsHealth care facilitiesArea of residenceLogistic regression modelsAfrican American womenSocioeconomic variablesControl womenBreast surgeryCancer mortalityPrivate health insuranceMedical CenterEffective treatmentStage IIIFine‐needle aspiration cytology of a subareolar abscess of the male breast
Silverman J, Raso D, Elsheikh T, Lannin D. Fine‐needle aspiration cytology of a subareolar abscess of the male breast. Diagnostic Cytopathology 1998, 18: 441-444. PMID: 9626518, DOI: 10.1002/(sici)1097-0339(199806)18:6<441::aid-dc11>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsFine needle aspiration cytologyMale breastSubareolar abscessSquamous cellsAspiration cytologyFNA cytologyNucleated squamous cellsType giant cellsMalignant squamous cellsCorrect FNA diagnosisUnusual benign lesionSubareolar regionNumerous neutrophilsDifferential diagnosisAppropriate treatmentFNA diagnosisBenign lesionsSpecial stainsMicrobiologic cultureGiant cellsAbscessBreastCytologyLesionsDiagnosis
1995
Breast Cancer in African‐American Families
ROYAK‐SCHALER R, DEVELLIS B, SORENSON J, WILSON K, LANNIN D, EMERSON J. Breast Cancer in African‐American Families. Annals Of The New York Academy Of Sciences 1995, 768: 281-285. PMID: 8526367, DOI: 10.1111/j.1749-6632.1995.tb12141.x.Peer-Reviewed Original Research
1994
Coming to terms with advanced breast cancer: Black women's narratives from Eastern North Carolina
Mathews H, Lannin D, Mitchell J. Coming to terms with advanced breast cancer: Black women's narratives from Eastern North Carolina. Social Science & Medicine 1994, 38: 789-800. PMID: 8184330, DOI: 10.1016/0277-9536(94)90151-1.Peer-Reviewed Original Research
1993
Difficulties in diagnosis of carcinoma of the breast in patients less than fifty years of age.
Lannin D, Harris R, Swanson F, Edwards M, Swanson M, Pories W. Difficulties in diagnosis of carcinoma of the breast in patients less than fifty years of age. Journal Of The American College Of Surgeons 1993, 177: 457-62. PMID: 8211596.Peer-Reviewed Original ResearchConceptsYears of ageDiagnosis of carcinomaYoung womenBreast clinicPhysical examinationPatient visitsOlder womenBreast Cancer Detection Demonstration ProjectAge groupsMore patient visitsDiffuse growth patternNon-palpable tumorsPercent of carcinomasPositive predictive valueMalpractice suitsMammary densityMedical factorsCarcinomaPredictive valueSignificant causeTumorsBreastDiagnosisPhysician errorWomenIncreasing Mammography Utilization: A Controlled Study
Fletcher S, Harris R, Gonzalez J, Degnan D, Lannin D, Strecher V, Pilgrim C, Quade D, Earp J, Clark R. Increasing Mammography Utilization: A Controlled Study. Journal Of The National Cancer Institute 1993, 85: 112-120. PMID: 8418300, DOI: 10.1093/jnci/85.2.112.Peer-Reviewed Original ResearchConceptsBreast cancer screeningPercentage of womenCancer screeningBreast cancerAge 50Women's knowledgeNational Cancer Institute's goalSecondary end pointsMedical record reviewPrimary care physiciansUse of mammographyCommunity-wide interventionsYears of ageMost demographic subgroupsNumber of mammogramsAnnual mammogramsAnnual mammographyRecord reviewMammography utilizationMedical recordsScreening practicesMammography screeningPhysician reportsPitt CountyScreening mammograms
1991
Mammography and age: Are we targeting the wrong women? A community survey of women and physicians
Harris R, Fletcher S, Gonzalez J, Lannin D, Degnan D, Earp J, Clark R. Mammography and age: Are we targeting the wrong women? A community survey of women and physicians. Cancer 1991, 67: 2010-2014. PMID: 2004318, DOI: 10.1002/1097-0142(19910401)67:7<2010::aid-cncr2820670730>3.0.co;2-8.Peer-Reviewed Original Research
1989
Fine‐needle aspiration cytology of breast masses in pregnant and lactating women
Finley J, Silverman J, Lannin D. Fine‐needle aspiration cytology of breast masses in pregnant and lactating women. Diagnostic Cytopathology 1989, 5: 255-259. PMID: 2791833, DOI: 10.1002/dc.2840050305.Peer-Reviewed Original ResearchConceptsFine-needle aspiration biopsyBreast massesAspiration biopsyFine needle aspiration cytologyAbundant vacuolated cytoplasmFalse-positive diagnosesInflammatory backgroundLobular hyperplasiaPregnant womenCytologic examinationPostpartum periodMicrotissue fragmentsAspiration cytologyClinical utilityEpithelial groupsNuclear pleomorphismVacuolated cytoplasmCellular smearsIrregular nucleoliMorphologic featuresProteinaceous debrisEpithelial cellsWomenBiopsySecretory type
1987
The triage role of fine needle aspiration biopsy of palpable breast masses. Diagnostic accuracy and cost-effectiveness.
Silverman J, Lannin D, O'Brien K, Norris H. The triage role of fine needle aspiration biopsy of palpable breast masses. Diagnostic accuracy and cost-effectiveness. Acta Cytologica 1987, 31: 731-6. PMID: 3425133.Peer-Reviewed Original ResearchConceptsFine-needle aspiration biopsyNeedle aspiration biopsyFalse-positive diagnosesFNA biopsyTriage roleMedical CenterAspiration biopsyFrozen section confirmationFrozen section biopsyTertiary medical centerPalpable breast massesFNA breast biopsyOutpatient biopsyHistologic confirmationExcisional biopsyLocal anesthesiaPrimary diagnosisSuspicious diagnosisInpatient proceduresBreast carcinomaNegative groupPositive groupBiopsyInsufficient diagnosisBreast biopsy
1986
Cost-Effectiveness of Fine Needle Biopsy of the Breast
LANNIN D, SILVERMAN J, WALKER C, PORIES W. Cost-Effectiveness of Fine Needle Biopsy of the Breast. Annals Of Surgery 1986, 203: 474-480. PMID: 3085603, PMCID: PMC1251147, DOI: 10.1097/00000658-198605000-00005.Peer-Reviewed Original Research