2023
Computational Random Mutagenesis to Investigate RAS Mutant Signaling
Stites E. Computational Random Mutagenesis to Investigate RAS Mutant Signaling. Methods In Molecular Biology 2023, 2634: 329-335. PMID: 37074586, PMCID: PMC10530643, DOI: 10.1007/978-1-0716-3008-2_15.Peer-Reviewed Original Research
2021
Mathematical Modeling to Study KRAS Mutant-Specific Responses to Pathway Inhibition
Stites E. Mathematical Modeling to Study KRAS Mutant-Specific Responses to Pathway Inhibition. Methods In Molecular Biology 2021, 2262: 311-321. PMID: 33977486, PMCID: PMC8639139, DOI: 10.1007/978-1-0716-1190-6_19.Peer-Reviewed Original ResearchConceptsRegulates Ras signalingMutant Ras proteinsKRAS G13D mutationRas proteinsRAS communityRas mutantsRas signalingRas pathwayBiochemical reactionsWild-typeRasMutationsPathway inhibitionG13D mutationDose-response experimentsMutantsKnowledge of reaction mechanismsInhibitionEGFR inhibitionKRAS mutationsProteinKRAS
2015
Cooperation between Noncanonical Ras Network Mutations
Stites E, Trampont P, Haney L, Walk S, Ravichandran K. Cooperation between Noncanonical Ras Network Mutations. Cell Reports 2015, 10: 307-316. PMID: 25600866, PMCID: PMC4503519, DOI: 10.1016/j.celrep.2014.12.035.Peer-Reviewed Original ResearchCollection of mutationsRAS pathway mutationsRas signaling networkGenomic data setsPathway mutationsTumor suppressor gene NF1Combinations of mutationsRandom mutagenesisRas mutantsNetwork genesSignaling networksGene NF1Genomic instabilityCancer phenotypeNF1 mutationsMutationsPromote cancerRasMutated cancersIncreased co-occurrenceMutantsMutagenesisGenesPhenotypeNF1
2014
Abstract PR04: Cooperation between Ras network mutations in cancer
Stites E, Trampont P, Haney L, Walk S, Ravichandran K. Abstract PR04: Cooperation between Ras network mutations in cancer. Molecular Cancer Research 2014, 12: pr04-pr04. DOI: 10.1158/1557-3125.rasonc14-pr04.Peer-Reviewed Original ResearchRas signaling networkSignaling networksGenomic dataRAS pathway mutationsRas mutantsNetwork mutationGenomic data setsCancer Cell Line EncyclopediaCancer genome sequencingPathway mutationsTumor suppressor gene NF1Wild-type cellsCancer genomic dataGenome sequenceTumor suppressor gene mutationsCancer Genome AtlasGene NF1Cell-based experimentsDisplay synergyMutational pathwaysRAS networkRas oncogeneCo-occurrenceMutationsRas
2012
Mathematical Investigation of How Oncogenic Ras Mutants Promote Ras Signaling
Stites E, Ravichandran K. Mathematical Investigation of How Oncogenic Ras Mutants Promote Ras Signaling. Methods In Molecular Biology 2012, 880: 69-85. PMID: 23361982, DOI: 10.1007/978-1-61779-833-7_5.Peer-Reviewed Original Research
2010
Modeling Membrane Localization: Case Study of a Ras Signaling Model
Stites E. Modeling Membrane Localization: Case Study of a Ras Signaling Model. Advances In Experimental Medicine And Biology 2010, 680: 661-667. PMID: 20865552, DOI: 10.1007/978-1-4419-5913-3_73.Peer-Reviewed Original Research