2024
ADVANCED SPERM AGE ≥50 YEAR IS ASSOCIATED WITH AN INCREASE IN SEGMENTAL ANEUPLOIDY RATES: A MULTI-SITE DONOR OOCYTE POPULATION STUDY OF 2124 BIOPSIED EMBRYOS WITH PGTSEQ
Barrett F, Kadesh A, Zhan Y, Gill P, Vessa B, Whitehead C, Puchalt N, Mounts E, Seli E, Werner M, Jalas C, Franasiak J. ADVANCED SPERM AGE ≥50 YEAR IS ASSOCIATED WITH AN INCREASE IN SEGMENTAL ANEUPLOIDY RATES: A MULTI-SITE DONOR OOCYTE POPULATION STUDY OF 2124 BIOPSIED EMBRYOS WITH PGTSEQ. Fertility And Sterility 2024, 122: e35. DOI: 10.1016/j.fertnstert.2024.07.164.Peer-Reviewed Original Research
2021
Noninvasive preimplantation genetic testing for aneuploidy exhibits high rates of deoxyribonucleic acid amplification failure and poor correlation with results obtained using trophectoderm biopsy
Hanson BM, Tao X, Hong KH, Comito CE, Pangasnan R, Seli E, Jalas C, Scott RT. Noninvasive preimplantation genetic testing for aneuploidy exhibits high rates of deoxyribonucleic acid amplification failure and poor correlation with results obtained using trophectoderm biopsy. Fertility And Sterility 2021, 115: 1461-1470. PMID: 33745720, DOI: 10.1016/j.fertnstert.2021.01.028.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyBlastocystCulture MediaEmbryo Culture TechniquesEmbryo ImplantationEmbryo TransferFemaleFertilityHigh-Throughput Nucleotide SequencingHumansInfertilityLive BirthMaleNoninvasive Prenatal TestingNucleic Acid Amplification TechniquesPredictive Value of TestsPregnancyPregnancy RatePreimplantation DiagnosisReproducibility of ResultsSperm Injections, IntracytoplasmicTime FactorsTreatment OutcomeWhole Genome SequencingConceptsPreimplantation genetic testingGenetic testingBiopsy resultsProspective cohort study SETTINGTrophectoderm biopsyTE biopsyNoninvasive preimplantation genetic testingCohort study SETTINGNext-generation sequencingHigh ratePrimary outcomeClinical outcomesMAIN OUTCOMEBiopsyStudy settingAmplification failureDiscordant resultsClinical applicabilityPrivate practiceNiPGTAvailable kitsCulture mediumShort durationOutcomesCulture medium samples