2020
Generation of pralatrexate resistant T‐cell lymphoma lines reveals two patterns of acquired drug resistance that is overcome with epigenetic modifiers
Scotto L, Kinahan C, Casadei B, Mangone M, Douglass E, Murty VV, Marchi E, Ma H, George C, Montanari F, Califano A, O'Connor OA. Generation of pralatrexate resistant T‐cell lymphoma lines reveals two patterns of acquired drug resistance that is overcome with epigenetic modifiers. Genes Chromosomes And Cancer 2020, 59: 639-651. PMID: 32614991, PMCID: PMC7540375, DOI: 10.1002/gcc.22884.Peer-Reviewed Original ResearchConceptsDihydrofolate reductaseResistant cell linesGene expression profilesCell linesT-cell lymphoma lineAntifolate pharmacologyEpigenetic modifiersExpression analysisGene expressionExpression profilesMechanistic basisT-cell selectivityParental H9 cellsIncreases expressionT-cell lymphomaSTAT5 phosphorylationMolecular targetsGene amplificationConcentration-dependent fashionLymphoma linesH9 cellsDrug resistancePutative mechanismsCellsPutative biomarkers
2011
Hodgkin’s Lymphoma Cell Lines Have up-Regulated IL-3 Receptor α (IL-3Rα) Expression and Are Sensitive to SL-401, An IL-3Rα Targeted Drug,
Diefenbach C, Sabado R, Brooks C, Baquero-Buitrago J, Cruz C, Vengco I, Montanari F, Marchi E, Scotto L, Cirrito T, Bergstein I, O'Connor O. Hodgkin’s Lymphoma Cell Lines Have up-Regulated IL-3 Receptor α (IL-3Rα) Expression and Are Sensitive to SL-401, An IL-3Rα Targeted Drug,. Blood 2011, 118: 3737. DOI: 10.1182/blood.v118.21.3737.3737.Peer-Reviewed Original ResearchHodgkin Reed-Sternberg cellsSL-401CD123 expressionHodgkin's lymphomaComplete responseTreatment strategiesLymphoma cell linesMyeloid leukemiaCell linesAutologous stem cell transplantMalignant Hodgkin Reed-Sternberg (HRS) cellsCell viabilityPrimary refractory diseaseRefractory Hodgkin lymphomaSecond-line chemotherapySecond-line therapyHigh expressionEffective therapeutic optionStem cell transplantReceptor α expressionAcute myeloid leukemiaChronic myeloid leukemiaClassical Hodgkin lymphomaPotential treatment strategyNovel treatment strategies