Featured Publications
Percutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies.
Dussik C, Toombs C, Alder K, Yu K, Berson E, Ibe I, Li F, Lindskog D, Friedlaender G, Latich I, Lee F. Percutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies. Radiology 2023, 307: e221401. PMID: 36916888, DOI: 10.1148/radiol.221401.Peer-Reviewed Original ResearchConceptsOsteolytic neoplasmAmbulatory functionInternal fixationEastern Cooperative Oncology Group scoreIndex scoreConversion hip arthroplastyRetrospective observational studySurgical site infectionKaplan-Meier analysisLong-term painQuality of lifeLong-term improvementWilcoxon signed-rank testNonambulatory patientsSecondary outcomesPrimary outcomeSite infectionOncologic careECOG scorePercutaneous ablationPeriacetabular metastasisProtrusio acetabuliFunctional improvementSigned-rank testClinical dataComparison of Percutaneous Interventional Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF), Long Intramedullary Nailing, and Hemiarthroplasty for the Treatment of Focal Metastatic Osteolytic Lesions in the Femoral Head and Neck
Jiang W, Friedlaender G, Lindskog D, Latich I, Lee F. Comparison of Percutaneous Interventional Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF), Long Intramedullary Nailing, and Hemiarthroplasty for the Treatment of Focal Metastatic Osteolytic Lesions in the Femoral Head and Neck. CardioVascular And Interventional Radiology 2023, 46: 649-657. PMID: 37052716, DOI: 10.1007/s00270-023-03425-x.Peer-Reviewed Original ResearchConceptsOsteolytic lesionsFemoral headSurgical complicationsRevision proceduresLong intramedullary nailingResultsSixty-seven patientsPost-operative complicationsEffective alternative treatmentTraditional surgical approachesAmbulatory scoreCombined painPrimary outcomeMedical complicationsMetastatic lesionsOncologic careRetrospective studyIntramedullary nailingSurgical approachFunction scoresNeck lesionsEarly improvementIM groupHemiarthroplastyComparative efficacyAlternative treatment
2020
Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones
Lee FY, Latich I, Toombs C, Mungur A, Conway D, Alder K, Ibe I, Lindskog D, Friedlaender G. Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones. Journal Of Vascular And Interventional Radiology 2020, 31: 649-658.e1. PMID: 32139256, DOI: 10.1016/j.jvir.2019.11.029.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAdultAgedAged, 80 and overBone CementsBone NeoplasmsBone RemodelingBone ScrewsCalcaneusCementoplastyFemaleFemoral NeoplasmsFemurFracture Fixation, InternalHumansMaleMiddle AgedOsteolysisPelvic BonesPostoperative ComplicationsProspective StudiesRecovery of FunctionTibiaTime FactorsTreatment OutcomeWeight-BearingConceptsOsteolytic lesionsInternal fixationVisual analog scale pain scoreMusculoskeletal Tumor Society scoreProspective clinical cohort studyFunctional ambulation scoreOsteolytic skeletal lesionsPainful osteolytic lesionsScale pain scoresClinical cohort studyInvasive percutaneous approachWeight-bearing boneInternal fixation screwsBalloon osteoplastyPain scoresCohort studyProphylactic stabilizationSevere painSociety ScoreConsecutive patientsSurgical treatmentEarly outcomesTreatment optionsPercutaneous approachFunctional improvement
2019
Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus.
Henderson S, Ibe I, Cahill S, Chung YH, Lee FY. Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus. Journal Of Bone And Joint Surgery 2019, 101: 1399-1410. PMID: 31393433, DOI: 10.2106/jbjs.18.01297.Peer-Reviewed Original ResearchConceptsType 2 diabetesPerioperative complicationsDiabetic patientsGlycemic controlBone healthType 1Type 2 diabetes mellitusNormal bone mineral densityPerioperative glycemic controlNon-diabetic patientsEarly bone lossSurgical site infectionAppropriate glycemic controlUnion of fractureRisk of fractureBone mineral densityType 1 diabetesAntiresorptive therapyOperative interventionDiabetes mellitusSclerostin antibodySite infectionMedical managementParathyroid hormonePostoperative managementBisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone
Greenberg DD, Lee FY. Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone. American Journal Of Clinical Oncology 2019, 42: 231-237. PMID: 30811352, DOI: 10.1097/coc.0000000000000504.Peer-Reviewed Original ResearchConceptsGiant cell tumorAdjuvant therapyLocal adjuvant therapySystemic side effectsAvascular necrosisCell tumorsSide effectsMusculoskeletal Tumor Society scoreOsteoclast-like giant cellsAggressive bone resorptionTherapeutic Level IVHigh-speed burringLocal recurrence rateAtypical femur fracturesLevel of evidenceTraditional adjuvant therapyBone cementAtypical fracturesSystemic bisphosphonatesPulmonary metastasesSociety ScoreCurettage proceduresRecurrence rateFemur fracturesPolymethylmethacrylate bone cement
2017
Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice
Mirza F, Lorenzo J, Drissi H, Lee FY, Soung DY. Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice. The Journal Of Nutritional Biochemistry 2017, 52: 54-61. PMID: 29149648, DOI: 10.1016/j.jnutbio.2017.10.002.Peer-Reviewed Original ResearchConceptsTumor necrosis factorTransgenic miceRheumatoid arthritisNuclear factor-kappa B activationDP dietBone-preserving propertiesReduction of synovitisPresence of TNFFour-week treatmentOnset of arthritisResistant acid phosphatase-positive cellsAcid phosphatase-positive cellsDestruction of jointsHuman synovial fibroblastsTNF-transgenic miceHuman tumor necrosis factorKappa B activationActivated T cellsFormation of osteoclastsMouse bone marrow macrophagesBone marrow macrophagesArticular cartilagePostmenopausal womenInflammatory arthritisBone erosion
2015
Activation of Protein Kinase A in Mature Osteoblasts Promotes a Major Bone Anabolic Response
Tascau L, Gardner T, Anan H, Yongpravat C, Cardozo CP, Bauman WA, Lee FY, Oh DS, Tawfeek HA. Activation of Protein Kinase A in Mature Osteoblasts Promotes a Major Bone Anabolic Response. Endocrinology 2015, 157: 112-126. PMID: 26488807, DOI: 10.1210/en.2015-1614.Peer-Reviewed Original ResearchMeSH KeywordsAMP-Activated Protein KinasesAnimalsBone DensityCells, CulturedEnergy MetabolismEnzyme ActivationFemaleFemurLumbar VertebraeMaleMice, Inbred C57BLMice, TransgenicOsteoblastsOsteocytesOsteogenesisPoint MutationPromoter Regions, GeneticSex CharacteristicsUp-RegulationX-Ray MicrotomographyConceptsBone anabolic responseOb miceMature osteoblastsPKA activationHigher basal PKA activityControl miceAnabolic responseProtein kinase ASerum bone turnover markersBone volume/total volumeBone turnover markersBasal PKA activityFemur cortical thicknessTotal tissue areaActive PKAKinase AConstitutive activationPKA activityTurnover markersBone lossAnabolic drugsStructure model indexOsteoclast numberFemale miceBone massOptimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones
Vorys GC, Bai H, Chandhanayingyong C, Lee CH, Compton JT, Caldwell JM, Gardner TR, Mao JJ, Lee FY. Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones. Clinical Biomechanics 2015, 30: 1114-1118. PMID: 26386637, PMCID: PMC9004608, DOI: 10.1016/j.clinbiomech.2015.08.016.Peer-Reviewed Original ResearchConceptsTorsional stiffnessHydroxyapatite composite scaffoldsCyclic torsional testsNon-locking fixationMassive segmental defectsTissue engineering strategiesLarge segmental bone defectsComposite scaffoldsLoading cyclesTorque controlSynthetic bone graftAxial stiffnessAngular rotationAxial compressionTorsional testsNon-destructive mannerGeometry representativeOptimal screw fixationSegmental bone defectsSuch scaffoldsTorque levelsStiffnessBiomechanical testingHuman tibiaEngineering strategies
2013
Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study
Amorosa L, Lee C, Aydemir, Nizami S, Hsu A, Patel N, Gardner T, Navalgund A, Kim DG, Park S, Mao J, Lee F. Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study. International Journal Of Nanomedicine 2013, Volume 8: 1637-1643. PMID: 23637532, PMCID: PMC3639117, DOI: 10.2147/ijn.s42855.Peer-Reviewed Original ResearchConceptsAddition of hMSCsPolymer-based scaffoldsLoad-bearing characteristicsPhysiologic cyclic loadingPhase angleCritical-sized segmental defectsScaffold alone groupViscous stiffnessCyclic loadingMechanical propertiesFemoral defect modelSized segmental defectsRat femoral defect modelHuman mesenchymal stem cellsMechanical simulationsScaffold groupDifferent biomechanical characteristicsEnhanced bone formationHigh phase anglesDefect modelBiomechanical characteristicsExperimental studyHost boneStiffnessDefect repair
2009
Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model
Cadet ER, Vorys GC, Rahman R, Park S, Gardner TR, Lee FY, Levine WN, Bigliani LU, Ahmad CS. Improving bone density at the rotator cuff footprint increases supraspinatus tendon failure stress in a rat model. Journal Of Orthopaedic Research® 2009, 28: 308-314. PMID: 19743506, DOI: 10.1002/jor.20972.Peer-Reviewed Original ResearchConceptsBone densityRotator cuff footprintOVX groupRat modelSupraspinatus tendonCuff footprintQuantitative micro-computed tomographyMonths of ageBisphosphonate treatmentOVX ratsBilateral ovariectomyProximal humerusDawley ratsAdditional ratsOVXRatsTendonOvariectomyMicro-computed tomographyTreatmentGroupBisphosphonatesSpragueHumerusMonths
2007
Coronal and Sagittal Plane Correction in Adolescent Idiopathic Scoliosis
Lowenstein JE, Matsumoto H, Vitale MG, Weidenbaum M, Gomez JA, Lee FY, Hyman JE, Roye DP. Coronal and Sagittal Plane Correction in Adolescent Idiopathic Scoliosis. Spine 2007, 32: 448-452. PMID: 17304136, DOI: 10.1097/01.brs.0000255030.78293.fd.Peer-Reviewed Original ResearchConceptsAdolescent idiopathic scoliosisMain thoracic curveScrew groupSagittal balanceScrew constructsThoracic curveIdiopathic scoliosisRetrospective cohort studyPosterior spinal fusionCoronal plane deformitySagittal plane correctionBetter correctionMean thoracic kyphosisRecent clinical researchSignificant differencesPedicle screw constructsCohort studyPostoperative radiographsConstruct groupMajor curvePlane deformitySpinal fusionThoracic kyphosisHybrid groupHook constructs
2006
TREATMENT OF CONGENITAL PSEUDARTHROSIS OF THE TIBIA WITH RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-7 (RHBMP-7)
LEE FY, SINICROPI SM, LEE FS, VITALE MG, ROYE DP, CHOI IH. TREATMENT OF CONGENITAL PSEUDARTHROSIS OF THE TIBIA WITH RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-7 (RHBMP-7). Journal Of Bone And Joint Surgery 2006, 88: 627-633. DOI: 10.2106/00004623-200603000-00023.Peer-Reviewed Original ResearchTreatment of Congenital Pseudarthrosis of the Tibia with Recombinant Human Bone Morphogenetic Protein-7 (rhBMP-7)
Lee F, Sinicropi S, Lee F, Vitale M, Roye D, Choi I. Treatment of Congenital Pseudarthrosis of the Tibia with Recombinant Human Bone Morphogenetic Protein-7 (rhBMP-7). Journal Of Bone And Joint Surgery 2006, 88: 627-633. PMID: 16510831, DOI: 10.2106/jbjs.d.02201.Peer-Reviewed Original ResearchThe effect of limb length discrepancy on health-related quality of life: is the ‘2 cm rule’ appropriate?
Vitale MA, Choe JC, Sesko AM, Hyman JE, Lee FY, Roye DP, Vitale MG. The effect of limb length discrepancy on health-related quality of life: is the ‘2 cm rule’ appropriate? Journal Of Pediatric Orthopaedics B 2006, 15: 1-5. PMID: 16280711, DOI: 10.1097/01202412-200601000-00001.Peer-Reviewed Original Research
2005
Assessment of Health Status in Patients With Cerebral Palsy
Vitale MG, Roye EA, Choe JC, Hyman JE, Lee FY, Roye DP. Assessment of Health Status in Patients With Cerebral Palsy. Journal Of Pediatric Orthopaedics 2005, 25: 792-797. PMID: 16294138, DOI: 10.1097/01.bpo.0000164870.26632.6b.Peer-Reviewed Original ResearchConceptsPediatric Outcomes Data Collection InstrumentChild Health QuestionnaireQuality of lifeCerebral palsyPediatric cerebral palsy populationFloor effectsCommon QoL instrumentsCerebral palsy populationPatient's actual conditionQuadriplegic groupHealth QuestionnaireHemiplegic groupPatient responseQOL instrumentsHealth statusDiagnostic groupsCeiling effectsPalsyFunctional rangeQuadriplegicsQuestionnaireDynamic assessmentGroupPopulationAssessmentOperative Lengthening of the Humerus
Lee FY, Schoeb JS, Yu J, Christiansen BD, Dick HM. Operative Lengthening of the Humerus. Journal Of Pediatric Orthopaedics 2005, 25: 613-616. PMID: 16199941, DOI: 10.1097/01.bpo.0000164868.97060.bb.Peer-Reviewed Original ResearchConceptsTemporary radial nerve palsyPosttraumatic growth disturbancesRadial nerve palsyUnicameral bone cystsElbow flexion contractureTime of lengtheningComplex neurovascular structuresImproved sports performanceHumeral lengtheningHumerus lengtheningOperative lengtheningNerve palsyMinor complicationsBone cystHumerus fracturesFlexion contractureMean ageCongenital anomaliesPin tractNeurovascular structuresPatientsAverage lengtheningComplicationsGrowth disturbanceDistraction osteogenesisCorrection of Adolescent Idiopathic Scoliosis Using Thoracic Pedicle Screw Fixation Versus Hook Constructs
Storer SK, Vitale MG, Hyman JE, Lee FY, Choe JC, Roye DP. Correction of Adolescent Idiopathic Scoliosis Using Thoracic Pedicle Screw Fixation Versus Hook Constructs. Journal Of Pediatric Orthopaedics 2005, 25: 415-419. PMID: 15958886, DOI: 10.1097/01.mph.0000165134.38120.87.Peer-Reviewed Original ResearchConceptsAdolescent idiopathic scoliosisThoracic pedicle screw fixationPedicle screw fixationHook constructsHook groupPatient groupScrew fixationIdiopathic scoliosisScrew groupMean preoperative Cobb angleScrew constructsPreoperative Cobb angleApical vertebral translationSignificant differencesQuality of lifeThoracic pedicle screwsThoracic pedicle screw constructsPedicle screw constructsOperative timeRetrospective studyPostoperative radiographsConsecutive casesCoronal balanceSurgical correctionSurgical timePatient-Based Outcomes Following Clubfoot Surgery
Vitale MG, Choe JC, Vitale MA, Lee FY, Hyman JE, Roye DP. Patient-Based Outcomes Following Clubfoot Surgery. Journal Of Pediatric Orthopaedics 2005, 25: 533-538. PMID: 15958910, DOI: 10.1097/01.bpo.0000157999.38424.ba.Peer-Reviewed Original ResearchConceptsPatient-based measuresClubfoot surgeryChild Health QuestionnaireDisease-specific instrumentLong-term outcomesPatient-based outcomesDisease-specific measuresCohort of adolescentsQuality of lifePrimary endpointSurgical repairPractice patternsHealth QuestionnaireAppropriate treatmentAuthors' institutionRadiographic measuresHealth outcomesTreatment resultsHealthy feetYoung athletesPatientsSurgeryOutcomesOngoing controversySimilar results
2004
Diagnostic value and limitations of fluorine-18 fluorodeoxyglucose positron emission tomography for cartilaginous tumors of bone.
Lee FY, Yu J, Chang SS, Fawwaz R, Parisien MV. Diagnostic value and limitations of fluorine-18 fluorodeoxyglucose positron emission tomography for cartilaginous tumors of bone. Journal Of Bone And Joint Surgery 2004, 86: 2677-85. PMID: 15590853, DOI: 10.2106/00004623-200412000-00014.Peer-Reviewed Original ResearchConceptsHigh-grade chondrosarcomaPositron emission tomographyStandardized uptake valueStandard uptake valueCartilage tumorsGlucose metabolismGrade IIUptake valueCartilaginous tumorsEmission tomographyTumor sizeHistopathologic gradePredictive valueFluorine-18 fluorodeoxyglucose positron emission tomographyLow-grade cartilage tumorsMaximal standard uptake valueMaximal standardized uptake valueFluorodeoxyglucose positron emission tomographyHigh standard uptake valueBenign bone tumorsHigh glucose metabolismNegative predictive valueSignificant differencesMalignant cartilaginous tumorsPositive predictive valueTreatment of allograft nonunions with recombinant human bone morphogenetic proteins (rhBMP).
Delloye C, Suratwala SJ, Cornu O, Lee FY. Treatment of allograft nonunions with recombinant human bone morphogenetic proteins (rhBMP). Acta Orthopaedica Belgica 2004, 70: 591-7. PMID: 15669462.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBone Morphogenetic ProteinsBone NeoplasmsBone TransplantationFemaleFollow-Up StudiesFractures, UnunitedHumansMaleMiddle AgedOsteosarcomaRadiographyRetrospective StudiesRisk AssessmentSampling StudiesSarcoma, EwingSensitivity and SpecificityTransplantation, HomologousTreatment OutcomeConceptsAllograft-host junctionAllograft nonunionRecombinant human bone morphogenetic proteinAllograft fractureIntercalary allograftsFracture nonunionHuman bone morphogenetic proteinAdditional radiation therapyMalignant bone tumorsRhBMP-7Allograft bone transplantationBone morphogenetic proteinAdjuvant chemotherapySterile drainageRadiological evidenceCorticocancellous allograftFemoral allograftsTibial nonunionWide resectionOsteoarticular allograftsTumor recurrenceMain complicationsNonunion siteBone tumorsRadiation therapy