2021
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses
Cui C, Wang J, Fagerberg E, Chen PM, Connolly KA, Damo M, Cheung JF, Mao T, Askari AS, Chen S, Fitzgerald B, Foster GG, Eisenbarth SC, Zhao H, Craft J, Joshi NS. Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses. Cell 2021, 184: 6101-6118.e13. PMID: 34852236, PMCID: PMC8671355, DOI: 10.1016/j.cell.2021.11.007.Peer-Reviewed Original ResearchConceptsCD8 TB cellsTfh cellsLung adenocarcinomaTfh-B cell interactionsTumor-specific B cellsFollicular helper cellsAnti-tumor immunityB cell signaturesCell effector functionsGerminal center formationGC B cellsCD4 THelper cellsTumor controlTumor neoantigensEffector functionsCell collaborationCell responsesCell signatureTumor cellsSignature correlatesNeoantigensCell functionCD4There won’T be blood
Gower M, Foster G, Tikhonova A. There won’T be blood. Nature Immunology 2021, 22: 396-397. PMID: 33753941, DOI: 10.1038/s41590-021-00893-6.Peer-Reviewed Original Research
2020
Inducible de novo expression of neoantigens in tumor cells and mice
Damo M, Fitzgerald B, Lu Y, Nader M, William I, Cheung JF, Connolly KA, Foster GG, Akama-Garren E, Lee DY, Chang GP, Gocheva V, Schmidt LM, Boileve A, Wilson JH, Cui C, Monroy I, Gokare P, Cabeceiras P, Jacks T, Joshi NS. Inducible de novo expression of neoantigens in tumor cells and mice. Nature Biotechnology 2020, 39: 64-73. PMID: 32719479, PMCID: PMC7854852, DOI: 10.1038/s41587-020-0613-1.Peer-Reviewed Original ResearchConceptsT cell responsesLevel of regulationRNA splicingDNA recombinationGenetic regulationTolerance mechanismsInducible expressionNeoantigen expressionCell responsesNaïve T-cell responsesCD4 T cell responsesTumor cell linesPeripheral tolerance mechanismsT cell toleranceCentral T cell toleranceCell linesExpressionNovo expressionTight controlEndogenous CD8Antitumor immunityPeripheral toleranceAutoimmune diseasesT cellsThymus resultsTreatment with Foscarnet after Allogeneic Hematopoietic Cell Transplant (Allo-HCT) Is Associated with Long-Term Loss of Renal Function
Foster GG, Grant MJ, Thomas SM, Cameron B, Raiff D, Corbet K, Loitsch G, Ferreri C, Horwitz M. Treatment with Foscarnet after Allogeneic Hematopoietic Cell Transplant (Allo-HCT) Is Associated with Long-Term Loss of Renal Function. Transplantation And Cellular Therapy 2020, 26: 1597-1606. PMID: 32450288, PMCID: PMC8026759, DOI: 10.1016/j.bbmt.2020.05.007.Peer-Reviewed Original ResearchConceptsAllogeneic hematopoietic cell transplantHematopoietic cell transplantChronic kidney diseaseRenal functionFoscarnet treatmentCell transplantHuman herpes virus-6 (HHV-6) reactivationLong-term renal functionAcute kidney injuryAcute kidney failureTransplant-related factorsAllo-HCTFoscarnet useMedian eGFRsKidney injuryAdult patientsFrequent indicationKidney diseaseKidney failureFoscarnetAnti-infective agentsMultivariate analysisPatientsOptimal managementMonths
2016
An Outbreak of Beta-2 Adrenergic Toxicity from Adulterated Heroin
Ali M, Foster Y, Brooks M, Roomiany P. An Outbreak of Beta-2 Adrenergic Toxicity from Adulterated Heroin. The American Journal Of Medicine 2016, 129: e125-e126. PMID: 27103048, PMCID: PMC6051537, DOI: 10.1016/j.amjmed.2016.03.027.Peer-Reviewed Original ResearchKeratomalacia in a Patient With Psychogenic Vitamin A Deficiency
Gospe SM, Todorich B, Foster YG, Legault G, Woods SK, Proia AD, Daluvoy M. Keratomalacia in a Patient With Psychogenic Vitamin A Deficiency. Cornea 2016, 35: 405-407. PMID: 26785304, DOI: 10.1097/ico.0000000000000732.Peer-Reviewed Original ResearchConceptsCorneal meltRight eyeHigh-dose vitamin ALarge corneal epithelial defectAnterior chamber inflammationPainful vision lossCorneal epithelial defectsVitamin A DeficiencySelf-induced vomitingBilateral keratomalaciaConjunctival xerosisLeft eyeSevere vitaminHistopathological findingsHistological findingsEpithelial defectsSerum vitaminCase reportVision lossGastrointestinal abnormalitiesA DeficiencyPanic disorderVitamin APatientsStrong index