1999
Amino Acid Substitutions Reveal Distinct Functions of Serine 186 of the ZEBRA Protein in Activation of Early Lytic Cycle Genes and Synergy with the Epstein-Barr Virus R Transactivator
Francis A, Ragoczy T, Gradoville L, Heston L, El-Guindy A, Endo Y, Miller G. Amino Acid Substitutions Reveal Distinct Functions of Serine 186 of the ZEBRA Protein in Activation of Early Lytic Cycle Genes and Synergy with the Epstein-Barr Virus R Transactivator. Journal Of Virology 1999, 73: 4543-4551. PMID: 10233912, PMCID: PMC112494, DOI: 10.1128/jvi.73.6.4543-4551.1999.Peer-Reviewed Original ResearchConceptsLytic cycle genesLatent virusZEBRA proteinOverexpression of RtaEpstein-Barr virusLatent EBV genomeBRLF1 expressionEarly lytic cycle genesAmino acid substitutionsEBV genomeBRLF1BRLF1 promoterCycle genesAcid substitutionsVirusEpstein-Barr virus R transactivatorSerine 186Distinct phenotypesLytic life cycleR transactivatorActivationDifferent amino acid substitutionsResponse elementS186Expression
1998
The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes
Ragoczy T, Heston L, Miller G. The Epstein-Barr Virus Rta Protein Activates Lytic Cycle Genes and Can Disrupt Latency in B Lymphocytes. Journal Of Virology 1998, 72: 7978-7984. PMID: 9733836, PMCID: PMC110133, DOI: 10.1128/jvi.72.10.7978-7984.1998.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceB-LymphocytesCell LineChloramphenicol O-AcetyltransferaseDNA PrimersDNA ReplicationDNA-Binding ProteinsGene Expression Regulation, ViralHerpesvirus 4, HumanHumansImmediate-Early ProteinsPromoter Regions, GeneticTrans-ActivatorsTranscription FactorsViral ProteinsVirus LatencyConceptsEpstein-Barr virusLytic cycle genesB lymphocytesEpstein–Barr virus Rta proteinEpithelial cellsLytic cycleDisruption of latencyViral lytic cycleB cell linesEBV entryImmediate early viral genesBZLF1LymphocytesCycle genesExpression of RTARTA functionBRLF1Rta proteinDownstream targetsViral genesViral DNA replicationExpressionCells