2024
TERT promoter mutations and additional molecular alterations in thyroid fine-needle aspiration specimens: A multi-institutional study with histopathologic follow-up
Abi-Raad R, Shi Q, Chen F, Antony V, Hsiao W, Simsir A, Liu X, Brandler T, Cai G. TERT promoter mutations and additional molecular alterations in thyroid fine-needle aspiration specimens: A multi-institutional study with histopathologic follow-up. American Journal Of Clinical Pathology 2024, aqae117. PMID: 39250709, DOI: 10.1093/ajcp/aqae117.Peer-Reviewed Original ResearchTERT promoter mutationsHistopathologic follow-upFine-needle aspirationTERT mutationsMolecular alterationsFollow-upPromoter mutationsThyroid carcinomaFine-needle aspiration diagnosisFine-needle aspiration specimensThyroid fine-needle aspiration specimensBenign thyroid neoplasmsSurgical follow-upAssociated with malignancyMulti-institutional studyThyroSeq v3Thyroid neoplasmsAspiration specimensTumor behaviorMalignant neoplasmsCarcinomaMalignancyNeoplasmsThyroidMutationsReevaluation of ovarian cyst fine-needle aspiration cytology: A 10-year institutional experience
Takeda K, Cai G, Adeniran A, Sun T. Reevaluation of ovarian cyst fine-needle aspiration cytology: A 10-year institutional experience. American Journal Of Clinical Pathology 2024, aqae077. PMID: 38916141, DOI: 10.1093/ajcp/aqae077.Peer-Reviewed Original ResearchCystic fluid cytologyFine-needle aspirationFluid cytologyAmerican College of Obstetricians and Gynecologists guidelinesSingle-institution cohortRate of malignancySurgical pathology diagnosisFNA casesGynecologists guidelinesCytological diagnosisFNA cytologyPathological diagnosisPatient demographicsInstitutional experienceSurgical pathologyOvarian cyst fluidClinical circumstancesAmerican CollegeCytologyRadiological informationMalignancyGold standardCyst fluidModerate sensitivityPotential safety concernsImproving diagnostic yield of pancreatic serous cystadenoma with cyst fluid ancillary testing, adjunct immunohistochemistry, and additional fine‐needle biopsy sampling
Wang X, Zhang X, Hui P, Cai G. Improving diagnostic yield of pancreatic serous cystadenoma with cyst fluid ancillary testing, adjunct immunohistochemistry, and additional fine‐needle biopsy sampling. Cancer Cytopathology 2024, 132: 425-434. PMID: 38450993, DOI: 10.1002/cncy.22808.Peer-Reviewed Original ResearchDiagnosis of serous cystadenomaFine-needle biopsyFine-needle aspirationCyst fluid carcinoembryonic antigenPancreatic serous cystadenomaSerous cystadenomaAncillary testsCEA levelsCytological diagnosisFine-needle aspiration cell blocksFine-needle aspiration diagnosisFine-needle aspiration casesCyst fluid CEA levelsSerous cystadenoma casesFluid carcinoembryonic antigenLow CEA levelFine-needle biopsy samplingKRAS mutation analysisWild-type KRASConcurrent fine-needle aspirationImprove diagnostic yieldInhibin immunostainingAtypical cellsCytology casesDiagnostic yield
2023
Respiratory Tract
Sardana R, Cai G. Respiratory Tract. 2023, 189-215. DOI: 10.1007/978-3-031-44289-6_11.Peer-Reviewed Original ResearchRespiratory tractNeedle aspirationKey cytomorphologic featuresCommon inflammatory conditionSpectrum of diagnosesTransbronchial needle aspirationFine-needle aspirationFalse-negative diagnosesBronchoalveolar lavageClinical symptomsBronchial washPulmonary pathologyInflammatory conditionsRespiratory cytologyBrush smearsCytomorphologic featuresCytological evaluationCytologic specimensInfectious diseasesDiagnosisTractDiagnostic processAspirationInitial investigationLavagePancreas
Wang X, Cai G. Pancreas. 2023, 229-245. DOI: 10.1007/978-3-031-44289-6_13.Peer-Reviewed Original ResearchFine-needle aspirationUtility of parathyroid hormone immunocytochemistry in fine needle aspiration diagnosis of parathyroid tissue
Sardana R, Abi‐Raad R, Adeniran A, Cai G. Utility of parathyroid hormone immunocytochemistry in fine needle aspiration diagnosis of parathyroid tissue. Cytopathology 2023, 34: 597-602. PMID: 37534757, DOI: 10.1111/cyt.13283.Peer-Reviewed Original ResearchConceptsParathyroid tissueFine-needle aspirationPTH casesClinicopathological characteristicsCytomorphological featuresThyroid lesionsThinPrep slidesFine needle aspiration diagnosisNeck soft tissuePatients' clinicopathological characteristicsNeedle aspiration diagnosisNegative predictive valueClinical suspicionStudy cohortPathology databaseRetrospective studyDiagnostic challengeDifferential diagnosisInstitutional experienceNeedle aspirationCytological diagnosisFNA casesAspiration diagnosisPredictive valueAdjunct test
2022
Comprehensive molecular profiling of pancreatic ductal adenocarcinoma in FNA, biopsy, and resection specimens
Razzano D, Bouza SJ, Hernandez PV, Wang M, Robert ME, Walther Z, Cai G. Comprehensive molecular profiling of pancreatic ductal adenocarcinoma in FNA, biopsy, and resection specimens. Cancer Cytopathology 2022, 130: 726-734. PMID: 35511415, DOI: 10.1002/cncy.22589.Peer-Reviewed Original ResearchConceptsFine-needle aspirationFine-needle biopsyPancreatic ductal adenocarcinomaOncomine Comprehensive AssayResection specimensMolecular alterationsMolecular testingFNB samplesDuctal adenocarcinomaTherapeutic implicationsSuccess rateComprehensive molecular analysisComprehensive molecular testingComprehensive molecular profilingPotential therapeutic implicationsSimilar success ratesResection casesKRAS mutationsFNB specimensFNA materialFNA specimensAmplification analysisMolecular profilingFusion assessmentGene mutations
2019
Economics, Regulations, and Trends in Practice
Levi A, Cai G. Economics, Regulations, and Trends in Practice. 2019, 407-412. DOI: 10.1007/978-3-030-21799-0_15.ChaptersFine-needle aspirationImaging-guided biopsyLaboratory resource utilizationPractice patternsNeedle aspiration- Metastatic tumorsLiver lesionsCore needle biopsyFine-needle aspirationHepatocyte lesionsPrimary tumorDefinite diagnosisDiagnostic challengeNeedle biopsyAncillary studiesHepatocellular carcinomaNeedle aspirationCytomorphologic featuresDiagnostic pitfallsLesion lesionsLesionsCytological featuresTumorsBiopsyMorphologic comparisonCholangiocarcinomaCarcinomaLiverDiagnosis
- Lung lesionsNon-small cell carcinomaNon-hematopoietic tumorsMediastinal lymph nodesFine-needle aspirationLymph nodesCell carcinomaHematopoietic lesionsNeedle aspirationCytomorphologic featuresDiagnostic pitfallsMolecular testingLesionsAppropriate specimen triageSpecimen triageSite evaluationBiopsyCarcinomaLungTumorsTriage
2016
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experience
Alomari AK, Ustun B, Aslanian HR, Ge X, Chhieng D, Cai G. Endoscopic ultrasound-guided fine-needle aspiration diagnosis of secondary tumors involving the pancreas: An institution's experience. CytoJournal 2016, 13: 1. PMID: 26955395, PMCID: PMC4763477, DOI: 10.4103/1742-6413.173585.Peer-Reviewed Original ResearchEndoscopic ultrasound-guided fine-needle aspirationSecondary tumorsAncillary studiesPrior historyDiagnostic pitfallsEndoscopic ultrasound‐guided fine‐needle aspiration diagnosisUltrasound-guided fine-needle aspirationLarge B-cell lymphomaFine needle aspiration diagnosisCommon metastatic tumorsRenal cell carcinomaB-cell lymphomaFine-needle aspirationPrimary pancreatic carcinomaMetastatic sarcomaClinical presentationSecondary involvementInstitution experienceLymphoproliferative disordersMetastatic carcinomaCell carcinomaMean ageMetastatic tumorsLung carcinomaCell neoplasms
2013
Evaluation of endobronchial ultrasound‐guided fine‐needle aspirations (EBUS‐FNA): Correlation with adequacy and histologic follow‐up
Karunamurthy A, Cai G, Dacic S, Khalbuss WE, Pantanowitz L, Monaco SE. Evaluation of endobronchial ultrasound‐guided fine‐needle aspirations (EBUS‐FNA): Correlation with adequacy and histologic follow‐up. Cancer Cytopathology 2013, 122: 23-32. PMID: 24127207, DOI: 10.1002/cncy.21350.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsy, NeedleCohort StudiesDatabases, FactualEndoscopic Ultrasound-Guided Fine Needle AspirationFalse Negative ReactionsFemaleHumansImmunohistochemistryLung NeoplasmsLymph NodesMaleMediastinal NeoplasmsMiddle AgedRetrospective StudiesSensitivity and SpecificityConceptsEndobronchial ultrasound-guided fine-needle aspirationUltrasound-guided fine-needle aspirationLymph nodesFine-needle aspirationDiagnostic yieldN1 lymph nodesN2 lymph nodesNegative cytologic diagnosisHilar lymph nodesMediastinal lymph nodesOverall diagnostic yieldChance of malignancyHigh diagnostic yieldNegative predictive valueFalse-negative diagnosesClinicopathologic findingsMediastinal lesionsLymphoid tissueInvasive modalitiesCytologic diagnosisPredictive valueUnsatisfactory casesGreater riskHistologicDiagnostic materialPerformance of endoscopic ultrasound-guided fine needle aspiration in diagnosing pancreatic neuroendocrine tumors
Bernstein J, Ustun B, Alomari A, Bao F, Aslanian HR, Siddiqui U, Chhieng D, Cai G. Performance of endoscopic ultrasound-guided fine needle aspiration in diagnosing pancreatic neuroendocrine tumors. CytoJournal 2013, 10: 10. PMID: 23858320, PMCID: PMC3709383, DOI: 10.4103/1742-6413.112648.Peer-Reviewed Original ResearchEndoscopic ultrasound-guided fine-needle aspirationPancreatic neuroendocrine tumorsUltrasound-guided fine-needle aspirationFine-needle aspirationNeuroendocrine tumorsNeedle aspirationCytological diagnosisMucinous cystic neoplasmSmall-sized tumorsDiagnosis of neoplasmRetrospective studyCystic neoplasmsRare tumorDefinite diagnosisDifferential diagnosisSized tumorsFNA diagnosisCytomorphologic featuresAtypical diagnosisDiagnostic pitfallsPatientsDiscrepant casesTumorsImmunocytochemical studyDiagnosis
2012
Cytoplasmic vacuolization: An under‐recognized cytomorphologic feature in endocrine tumors of the pancreas
Levy GH, Finkelstein A, Harigopal M, Chhieng D, Cai G. Cytoplasmic vacuolization: An under‐recognized cytomorphologic feature in endocrine tumors of the pancreas. Diagnostic Cytopathology 2012, 41: 623-628. PMID: 22807461, DOI: 10.1002/dc.22893.Peer-Reviewed Original ResearchConceptsFine-needle aspirationPancreatic endocrine neoplasmsCytomorphologic featuresDiagnostic pitfallsEndoscopic ultrasound-guided fine-needle aspirationUltrasound-guided fine-needle aspirationFine cytoplasmic vacuolesClinicopathologic featuresDiagnostic challengeEndocrine tumorsEndocrine neoplasmsSmall biopsiesAccurate diagnosisImmunocytochemical studyCytoplasmic vacuoles