2020
A Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing
Dash BC, Setia O, Gorecka J, Peyvandi H, Duan K, Lopes L, Nie J, Berthiaume F, Dardik A, Hsia HC. A Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing. Cells 2020, 9: 966. PMID: 32295218, PMCID: PMC7226960, DOI: 10.3390/cells9040966.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsSecretory functionHuman-induced pluripotent stem cellsParacrine secretionMuscle cellsCollagen fibrillar densitiesSecretory factorsVascular regenerationWound healingTissue-engineered vascular graftsHealingVascular graftsStem cellsPluripotent stem cellsCollagen scaffoldsScaffold propertiesScaffold materialsCellsPromising strategyDisease modelingFibrillar densityRegenerative wound healingCytokinesGraftInduced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing
Gorecka J, Gao X, Fereydooni A, Dash BC, Luo J, Lee SR, Taniguchi R, Hsia HC, Qyang Y, Dardik A. Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing. Regenerative Medicine 2020, 15: 1277-1293. PMID: 32228292, PMCID: PMC7304438, DOI: 10.2217/rme-2019-0086.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsMuscle cellsDiabetic wound healingWound healingPro-angiogenic cytokinesMurine AdiposeStem cellsType macrophagesCollagen scaffoldsCultured mediumM2-type macrophagesCellsNumber of totalNew candidatesAngiogenesisNude miceDiabetic woundsPromising new candidateScaffoldsHealingCytokinesExpressionSecreteWoundsAdipose
2019
Evidence-Based Gardening: Using Palliative Approaches to Cure Complex Wounds.
Ching AH, Le N, Norwich-Cavanaugh A, Hsia HC. Evidence-Based Gardening: Using Palliative Approaches to Cure Complex Wounds. Annals Of Plastic Surgery 2019, 83: s45-s49. PMID: 31513065, DOI: 10.1097/sap.0000000000002100.Peer-Reviewed Original ResearchMouse Model of Pressure Ulcers After Spinal Cord Injury.
Kumar S, Tan Y, Yarmush ML, Dash BC, Hsia HC, Berthiaume F. Mouse Model of Pressure Ulcers After Spinal Cord Injury. Journal Of Visualized Experiments 2019 PMID: 30907872, DOI: 10.3791/58188.Peer-Reviewed Original ResearchConceptsSpinal cord injuryLevel of SCIPressure ulcersSCI miceCord injuryMouse modelComplete spinal cord injuryImpact of SCITraumatic spinal cord injuryComplete spinal cord transectionSpinal cord transectionAdult male miceRelevant mouse modelCord transectionIschemic areaMale miceTissue edemaPU developmentTherapeutic approachesAnimal modelsBony prominencesSuch woundsMiceSoft tissueHealing
2018
The Impact of Microbial Communities on Wound Healing
Xu Z, Hsia HC. The Impact of Microbial Communities on Wound Healing. Annals Of Plastic Surgery 2018, 81: 113-123. PMID: 29746280, DOI: 10.1097/sap.0000000000001450.Peer-Reviewed Original ResearchConceptsWound healingVenous insufficiency ulcersHealth care systemClinical factorsDefinitive treatmentDiabetic footPressure ulcersMicrobiome findingsAcute woundsImproved healingEnormous burdenChronic woundsComparison of findingsWound microbiotaBacteriophage therapyCare systemWound microbiomeExact roleWoundsHealingMore studiesUlcersMicrobiome compositionMajor bacteriaMicrobiome