2024
Self-Assembled Fibroblast Growth Factor Nanoparticles as a Therapeutic for Oxidant-Induced Neuronal and Skin Cell Injury
Kumar S, Chu A, Theis T, Rastogi S, Costea D, Banerjee R, Das B, Yarmush M, Hsia H, Cohen R, Schachner M, Berthiaume F. Self-Assembled Fibroblast Growth Factor Nanoparticles as a Therapeutic for Oxidant-Induced Neuronal and Skin Cell Injury. ACS Applied Bio Materials 2024, 7: 5158-5170. PMID: 39038169, DOI: 10.1021/acsabm.4c00135.Peer-Reviewed Original ResearchSpinal cord injuryFGF-2Cell injuryTraumatic brain injurySkin wound healingResponses in vivoInflammatory response in vivoWound healingPressure woundsOxidant-mediated injuryFibroblast growth factor-2Growth factor 2Delayed injuryLocal inflammationNanoparticle sizeChronic skin woundsSecondary complicationsCultured neuronal cellsEndothelial cellsGrowth factorPromote neurite outgrowthCord injuryNeurological sensationsRecombinant fusion proteinNanoparticlesCellular therapeutics and immunotherapies in wound healing – on the pulse of time?
Huelsboemer L, Knoedler L, Kochen A, Yu C, Hosseini H, Hollmann K, Choi A, Stögner V, Knoedler S, Hsia H, Pomahac B, Kauke-Navarro M. Cellular therapeutics and immunotherapies in wound healing – on the pulse of time? Military Medical Research 2024, 11: 23. PMID: 38637905, PMCID: PMC11025282, DOI: 10.1186/s40779-024-00528-5.Peer-Reviewed Original ResearchConceptsStandard of careChronic wound healing disordersLocal wound irrigationWound healingChronic inflammatory microenvironmentFree flap techniqueWound healing disordersChronic woundsGenetic risk profilesPhysiological wound healingAdequate blood supplySurgical debridementFlap techniqueCellular therapyCurrent therapiesHealing disordersInflammatory microenvironmentWound irrigationNon-healing woundsCellular therapeuticsGeneral anesthesiaFormation of biofilmsWound debridementSkin graftsImmunotherapy
2023
Apoptosis recognition receptors regulate skin tissue repair in mice
Justynski O, Bridges K, Krause W, Forni M, Phan Q, Sandoval-Schaefer T, Carter K, King D, Hsia H, Gazes M, Vyce S, Driskell R, Miller-Jensen K, Horsley V. Apoptosis recognition receptors regulate skin tissue repair in mice. ELife 2023, 12: e86269. PMID: 38127424, PMCID: PMC10735221, DOI: 10.7554/elife.86269.Peer-Reviewed Original Research
2020
An in situ collagen‐HA hydrogel system promotes survival and preserves the proangiogenic secretion of hiPSC‐derived vascular smooth muscle cells
Dash BC, Duan K, Xing H, Kyriakides TR, Hsia HC. An in situ collagen‐HA hydrogel system promotes survival and preserves the proangiogenic secretion of hiPSC‐derived vascular smooth muscle cells. Biotechnology And Bioengineering 2020, 117: 3912-3923. PMID: 32770746, DOI: 10.1002/bit.27530.Peer-Reviewed Original ResearchSelf-Assembled Nanomaterials for Chronic Skin Wound Healing
Kang HJ, Chen N, Dash BC, Hsia HC, Berthiaume F. Self-Assembled Nanomaterials for Chronic Skin Wound Healing. Advances In Wound Care 2020, 10: 221-233. PMID: 32487014, PMCID: PMC8024239, DOI: 10.1089/wound.2019.1077.Peer-Reviewed Original ResearchConceptsSelf-assembled nanomaterialsDrug delivery capabilityNanomaterialsWound healing applicationsTunable mechanicsExcellent biocompatibilityMultifunctional propertiesPhysiochemical propertiesMultiple functionalitiesDelivery systemComplex multifunctional structuresDelivery capabilityHealing applicationsWound dressingsPropertiesMultifunctional structuresLow costChronic wound healing applicationsBiocompatibilityGrowth factor delivery systemEffective wound therapyMaterialsDegradationMechanismStructureA Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing
Dash BC, Setia O, Gorecka J, Peyvandi H, Duan K, Lopes L, Nie J, Berthiaume F, Dardik A, Hsia HC. A Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing. Cells 2020, 9: 966. PMID: 32295218, PMCID: PMC7226960, DOI: 10.3390/cells9040966.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsSecretory functionHuman-induced pluripotent stem cellsParacrine secretionMuscle cellsCollagen fibrillar densitiesSecretory factorsVascular regenerationWound healingTissue-engineered vascular graftsHealingVascular graftsStem cellsPluripotent stem cellsCollagen scaffoldsScaffold propertiesScaffold materialsCellsPromising strategyDisease modelingFibrillar densityRegenerative wound healingCytokinesGraftSafety of compression therapy for venous ulcer disease in the setting of congestive heart failure
Attaran RR, Cavanaugh A, Tsay C, Ahmad T, Chaar C, Persing S, Hsia H. Safety of compression therapy for venous ulcer disease in the setting of congestive heart failure. Phlebology The Journal Of Venous Disease 2020, 35: 556-560. PMID: 32028849, DOI: 10.1177/0268355520905178.Peer-Reviewed Original ResearchConceptsCongestive heart failureCongestive heart failure populationVenous ulcer diseaseHeart failure populationHeart failureCompression therapyUlcer diseaseFailure populationCongestive heart failure exacerbationStable congestive heart failureDiuretic dose increaseHeart failure exacerbationMainstay of treatmentHeart failure decompensationWound care centerLarge teaching hospitalRetrospective reviewCare centerPatient outcomesTeaching hospitalRegistry dataPatientsTherapyWeight gainCompression periodInduced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing
Gorecka J, Gao X, Fereydooni A, Dash BC, Luo J, Lee SR, Taniguchi R, Hsia HC, Qyang Y, Dardik A. Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing. Regenerative Medicine 2020, 15: 1277-1293. PMID: 32228292, PMCID: PMC7304438, DOI: 10.2217/rme-2019-0086.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsMuscle cellsDiabetic wound healingWound healingPro-angiogenic cytokinesMurine AdiposeStem cellsType macrophagesCollagen scaffoldsCultured mediumM2-type macrophagesCellsNumber of totalNew candidatesAngiogenesisNude miceDiabetic woundsPromising new candidateScaffoldsHealingCytokinesExpressionSecreteWoundsAdipose
2019
Evidence-Based Gardening: Using Palliative Approaches to Cure Complex Wounds.
Ching AH, Le N, Norwich-Cavanaugh A, Hsia HC. Evidence-Based Gardening: Using Palliative Approaches to Cure Complex Wounds. Annals Of Plastic Surgery 2019, 83: s45-s49. PMID: 31513065, DOI: 10.1097/sap.0000000000002100.Peer-Reviewed Original ResearchCan Nicotine Replacement Therapy Decrease Complications in Plastic Surgery?
Xu Z, Norwich-Cavanaugh A, Hsia HC. Can Nicotine Replacement Therapy Decrease Complications in Plastic Surgery? Annals Of Plastic Surgery 2019, 83: s55-s58. PMID: 31513067, DOI: 10.1097/sap.0000000000002095.Peer-Reviewed Original ResearchConceptsNicotine replacementHigh-level evidencePlastic surgery proceduresPostoperative periodSurgical patientsCessation therapyClinical outcomesCigarette smokingProspective studySmoking cessationAdverse outcomesDecrease complicationsClinical trialsEffective modalityOptimizing outcomesSurgery proceduresElectronic cigarettesPatient safetyPlastic surgeonsPlastic surgeryComplicationsPatientsOutcomesRiskModalitiesTargeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing.
Hetzler PT, Dash BC, Guo S, Hsia HC. Targeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing. Annals Of Plastic Surgery 2019, 83: e92-e95. PMID: 31246672, PMCID: PMC6851445, DOI: 10.1097/sap.0000000000001955.Peer-Reviewed Original ResearchConceptsTherapeutic targetAberrant wound healing processAppropriate physiologic responseMorbid disease processSurvival of myofibroblastsWound healingFibrotic signaling pathwaysTranscription factor/serum response factor (MRTF/SRF) pathwayFuture therapeutic targetsSmooth muscle actinFuture translational researchCurrent literatureFibrotic signalingTherapeutic optionsFibrotic lesionsTissue injuryWound healing processDisease processPhysiologic responsesSerum response factor pathwayMuscle actinFactor pathwayExcessive responseFibrosisTranslational researchSignificance of Friction and Shear in the Prevention of Contemporary Hospital-acquired Pressure Ulcers
Cabrejo R, Ndon S, Saberski E, Chuang C, Hsia HC. Significance of Friction and Shear in the Prevention of Contemporary Hospital-acquired Pressure Ulcers. Plastic & Reconstructive Surgery Global Open 2019, 7: e2099. PMID: 31321159, PMCID: PMC6554149, DOI: 10.1097/gox.0000000000002099.Peer-Reviewed Original ResearchClinical Value of Single-photon Emission Computed Tomography Combined With Computed Tomography for Sentinel Lymph Node Identification in Melanoma.
McGregor A, Kim S, Norwich-Cavanaugh A, Sun AH, Abbate DS, Hsia HC, Narayan D. Clinical Value of Single-photon Emission Computed Tomography Combined With Computed Tomography for Sentinel Lymph Node Identification in Melanoma. Annals Of Plastic Surgery 2019, 82: s192-s194. PMID: 30855387, DOI: 10.1097/sap.0000000000001895.Peer-Reviewed Original ResearchConceptsSPECT/CTSentinel lymph nodesLymph nodesIntraoperative findingsSingle photon emissionSentinel lymphSurgical approachComputed tomographyOperative planPreoperative SPECT/CTSentinel lymph node identificationDistant metastatic diseasePalpable lymph nodesRetrospective chart reviewSentinel node biopsyVeterans Affairs hospitalLymph node identificationIntraoperative lymphoscintigraphyNeck melanomaPrimary endpointChart reviewMetastatic diseaseNode biopsySLN identificationMelanoma patientsAn Algorithm for the Management of Residual Head and Neck Melanoma In Situ Using Topical Imiquimod: A Pilot Study.
Tsay C, Kim S, Norwich-Cavanaugh A, Hsia HC, Narayan D. An Algorithm for the Management of Residual Head and Neck Melanoma In Situ Using Topical Imiquimod: A Pilot Study. Annals Of Plastic Surgery 2019, 82: s199-s201. PMID: 30855388, DOI: 10.1097/sap.0000000000001840.Peer-Reviewed Original ResearchConceptsTopical imiquimodNeck melanomaSurgical excisionCure rateAtypical squamous cell carcinomaComparable cure ratesSquamous cell carcinomaDuration of treatmentLength of treatmentFrequency of treatmentStage T1aActive inflammationStandard therapyInitial biopsyResidual inflammationPatient adherencePositive marginsResidual diseaseCell carcinomaCertain patientsSkin biopsiesComplete excisionFunctional impairmentInclusion criteriaDifficult lesionsIncisional Negative Pressure Wound Therapy Augments Perfusion and Improves Wound Healing in a Swine Model Pilot Study.
Shah A, Sumpio BJ, Tsay C, Swallow M, Dash B, Thorn SL, Sinusas AJ, Koo A, Hsia HC, Au A. Incisional Negative Pressure Wound Therapy Augments Perfusion and Improves Wound Healing in a Swine Model Pilot Study. Annals Of Plastic Surgery 2019, 82: s222-s227. PMID: 30855392, DOI: 10.1097/sap.0000000000001842.Peer-Reviewed Original ResearchConceptsNegative pressure wound therapyVascular endothelial growth factorClosed woundsUse of NPWTVEGF expressionSurgical wound sitePressure wound therapyMale Yorkshire pigsEnzyme-linked immunosorbent assay resultsEnzyme-linked immunosorbent assayEndothelial growth factorExcisional wound modelImmunosorbent assay resultsControl dressingsPrimary sutureScar evaluationImmunohistochemistry stainingIncision siteNPWT dressingsWound therapyAngiogenesis markersTreatment groupsAppearance of woundsOpen woundsWound healing modelThe potential and limitations of induced pluripotent stem cells to achieve wound healing
Gorecka J, Kostiuk V, Fereydooni A, Gonzalez L, Luo J, Dash B, Isaji T, Ono S, Liu S, Lee SR, Xu J, Liu J, Taniguchi R, Yastula B, Hsia HC, Qyang Y, Dardik A. The potential and limitations of induced pluripotent stem cells to achieve wound healing. Stem Cell Research & Therapy 2019, 10: 87. PMID: 30867069, PMCID: PMC6416973, DOI: 10.1186/s13287-019-1185-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic woundsCell therapyStem cellsDiabetic foot ulcersCell typesWound healingInvasive harvesting techniquesAdult-derived stem cellsNormal skin architecturePluripotent stem cellsLimb ischemiaFoot ulcersLimited cell survivalSafety profileOnly cell typeAnimal modelsHuman studiesPotential treatmentPhysiologic responsesHealthy skinImmune rejectionAdvanced therapiesTranslational potentialUse of iPSCsSystemic factorsMouse Model of Pressure Ulcers After Spinal Cord Injury.
Kumar S, Tan Y, Yarmush ML, Dash BC, Hsia HC, Berthiaume F. Mouse Model of Pressure Ulcers After Spinal Cord Injury. Journal Of Visualized Experiments 2019 PMID: 30907872, DOI: 10.3791/58188.Peer-Reviewed Original ResearchConceptsSpinal cord injuryLevel of SCIPressure ulcersSCI miceCord injuryMouse modelComplete spinal cord injuryImpact of SCITraumatic spinal cord injuryComplete spinal cord transectionSpinal cord transectionAdult male miceRelevant mouse modelCord transectionIschemic areaMale miceTissue edemaPU developmentTherapeutic approachesAnimal modelsBony prominencesSuch woundsMiceSoft tissueHealing
2018
Impact of Acellular Dermal Matrix on Postsurgical Wound Fluid Biomarkers in Prosthetic Breast Reconstruction
Hsia HC, Weaver MR, Schwarzbauer JE. Impact of Acellular Dermal Matrix on Postsurgical Wound Fluid Biomarkers in Prosthetic Breast Reconstruction. Annals Of Plastic Surgery 2018, 81: s89-s96. PMID: 29851721, DOI: 10.1097/sap.0000000000001495.Peer-Reviewed Original ResearchConceptsAcellular dermal matrixProsthetic breast reconstructionInitial postoperative periodBreast reconstructionDermal matrixPostoperative periodFluid biomarkersTime pointsBody mass indexSurgical wound fluidBreast reconstruction surgeryFluid samplesMatrix metalloproteinase activitySoft tissue reinforcementExtracellular matrix protein levelsPresent groupWound fluid samplesBiologic scaffoldsSingle surgeonMass indexSurgical drainsReconstruction surgeryCell proliferation activityBlinded fashionSimilar demographicsMyofibroblast proliferation and heterogeneity are supported by macrophages during skin repair
Shook BA, Wasko RR, Rivera-Gonzalez GC, Salazar-Gatzimas E, López-Giráldez F, Dash BC, Muñoz-Rojas AR, Aultman KD, Zwick RK, Lei V, Arbiser JL, Miller-Jensen K, Clark DA, Hsia HC, Horsley V. Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair. Science 2018, 362 PMID: 30467144, PMCID: PMC6684198, DOI: 10.1126/science.aar2971.Peer-Reviewed Original ResearchConceptsDifferential gene expressionAdipocyte precursorsExtracellular matrix moleculesGene expressionTransplantation assaysMatrix moleculesFactor C.Factor 1Insulin-like growth factor-1Cell populationsTissue resilienceDistinct subpopulationsGrowth factor-1Profibrotic cellsTissue repairMultiple mouse modelsECM depositionSkin repairTissue dysfunctionProliferationMouse modelMyofibroblastsWoundingMacrophagesRepairTelehealth in Plastic Surgery
Douglas S, Geiger E, McGregor A, Norwich A, Abbate D, Hsia H, Narayan D. Telehealth in Plastic Surgery. Plastic & Reconstructive Surgery Global Open 2018, 6: e1840. PMID: 30534478, PMCID: PMC6250470, DOI: 10.1097/gox.0000000000001840.Peer-Reviewed Original ResearchPlastic surgery consultationSurgery consultationPlastic surgeryVA systemCarpal tunnel syndromeHigh patient satisfactionNonurgent diagnosesPostvisit questionnairesEligible patientsTelehealth visitsSubspecialty careTunnel syndromePatient satisfactionPatients' attitudesSkin lesionsPatientsVideo telemedicineTelehealth programValue of telehealthTelehealth servicesChronic woundsSurgeryPlastic surgeonsConsultation serviceFurther studies