Metabolic signatures of regulation by phosphorylation and acetylation
Smith K, Shen F, Lee H, Chandrasekaran S. Metabolic signatures of regulation by phosphorylation and acetylation. IScience 2022, 25: 103730. PMID: 35072016, PMCID: PMC8762462, DOI: 10.1016/j.isci.2021.103730.Peer-Reviewed Original ResearchPosttranslational modificationsTarget of phosphorylationGenome-scale metabolic networksRational rewiringRegulatory circuitsMammalian cellsCellular metabolismMetabolic networksPhosphorylated enzymeMetabolic regulationPhosphoproteome datasetEnzyme propertiesPhosphorylationAcetylationMetabolic signaturesRegulationAcetylomeTranscriptomeDiverse conditionsProteomePhosphoproteomicsTargetCondition-specific factorsEssentialityOrganismsControllability analysis of the directed human protein interaction network identifies disease genes and drug targets
Vinayagam A, Gibson TE, Lee HJ, Yilmazel B, Roesel C, Hu Y, Kwon Y, Sharma A, Liu YY, Perrimon N, Barabási AL. Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 4976-4981. PMID: 27091990, PMCID: PMC4983807, DOI: 10.1073/pnas.1603992113.Peer-Reviewed Original ResearchConceptsPPI networkDisease genesProtein-protein interaction networkDrug targetsCellular information processingHuman PPI networkNovel disease genesCopy number alteration dataPotential drug targetsNumber alteration dataDisease-causing mutationsIndispensable proteinsInteraction networksCell deathGenesProteinCell proliferationDifferent cancersHuman virusesPrimary targetAlteration dataDisease statesTargetMutationsNetwork control properties