Featured Publications
How Far Is Too Far? Cost-Effectiveness Analysis of Regionalized Rectal Cancer Surgery
Leeds I, Xu Z, Loria A, Pantel H, Mongiu A, Longo W, Reddy V. How Far Is Too Far? Cost-Effectiveness Analysis of Regionalized Rectal Cancer Surgery. Diseases Of The Colon & Rectum 2022, 66: 467-476. PMID: 36538713, DOI: 10.1097/dcr.0000000000002636.Peer-Reviewed Original ResearchConceptsMultivariable probabilistic sensitivity analysesCost-effectiveness standardsIncremental cost-effectiveness ratioProbabilistic sensitivity analysesCost-effectiveness analysisCost-effectiveness ratioTotal societal costsSensitivity analysisDecision analysis modelEl análisisSocietal perspectiveIncremental costPacientes con cáncerSocietal costsLos costosLargo plazoPolicy levelDecision analysisTotal costCostCost-Effectiveness of Aspirin for Extended Venous Thromboembolism Prophylaxis After Major Surgery for Inflammatory Bowel Disease
Leeds IL, Sklow B, Gorgun E, Liska D, Lightner AL, Hull TL, Steele SR, Holubar SD. Cost-Effectiveness of Aspirin for Extended Venous Thromboembolism Prophylaxis After Major Surgery for Inflammatory Bowel Disease. Journal Of Gastrointestinal Surgery 2022, 26: 1275-1285. PMID: 35277799, DOI: 10.1007/s11605-022-05287-z.Peer-Reviewed Original ResearchConceptsInflammatory bowel disease surgeryLow-dose aspirinQuality-adjusted life yearsThromboembolism prophylaxisDisease surgeryUnfavorable incremental cost-effectiveness ratiosLife yearsExtended venous thromboembolism prophylaxisPost-discharge event ratePocket costsIncremental cost-effectiveness ratioVenous thromboembolism prophylaxisEfficacy of aspirinInflammatory bowel diseaseMedian hospital costsMonte Carlo probabilistic sensitivity analysisCost-effectiveness ratioProbabilistic sensitivity analysesDecision analysis modelEnoxaparin regimenThromboembolism ratesVenous thromboembolismBowel diseaseColorectal surgeryCase patientsOn All Accounts: Cost-Effectiveness Analysis of Limited Preoperative Optimization Efforts Before Colon Cancer Surgery
Leeds IL, Drabo EF, Lehmann LS, Safar B, Johnston FM. On All Accounts: Cost-Effectiveness Analysis of Limited Preoperative Optimization Efforts Before Colon Cancer Surgery. Diseases Of The Colon & Rectum 2021, 64: 744-753. PMID: 33955409, PMCID: PMC8835996, DOI: 10.1097/dcr.0000000000001926.Peer-Reviewed Original ResearchConceptsCost-effectiveness analysisProbabilistic sensitivity analysesNet monetary benefitIncremental cost-effectiveness ratioTotal costCost-effectiveness ratioMonetary benefitsSensitivity analysisBreakeven costDominant strategyEconomic costsDecision analysis methodologyCostHypothetical scenariosAlto riesgoEl análisisAnálisisEconómicoBenefitsAnalysis methodologyReducciónRescuing Failure to Rescue—Patient Safety Indicator 04 on the Brink of Obsolescence
Leeds IL, Kachalia A, Haut ER. Rescuing Failure to Rescue—Patient Safety Indicator 04 on the Brink of Obsolescence. JAMA Surgery 2021, 156: 115-116. PMID: 33026428, DOI: 10.1001/jamasurg.2020.2971.Peer-Reviewed Original Research
2024
Pelvic Floor Physical Therapy Prehabilitation (PrePFPT) for the prevention of low anterior resection syndrome
Coppersmith N, Schultz K, Esposito A, Reinhart K, Ray E, Leeds I, Pantel H, Reddy V, Longo W, Mongiu A. Pelvic Floor Physical Therapy Prehabilitation (PrePFPT) for the prevention of low anterior resection syndrome. Surgical Oncology Insight 2024, 1: 100097. DOI: 10.1016/j.soi.2024.100097.Peer-Reviewed Original ResearchLow anterior resection syndromeAnterior resection syndromePelvic floor physical therapyQuality of life outcomesSymptoms of low anterior resection syndromeImprove patient qualityPhysical therapyRectal cancerPrehabilitationDevelopment of low anterior resection syndromeStudy designTreatment of low anterior resection syndromeTreatment of rectal cancerIncidence of low anterior resection syndromeLife outcomesEvaluated pre-Patients' qualityRectal cancer patientsCancer patientsDevelopment of symptomsNeoadjuvant chemoradiotherapyDefecatory dysfunctionImproved recoveryInternational trialsSyndromeAssociation Between Chemotherapy-Induced Peripheral Neuropathy and Low Anterior Resection Syndrome
Linhares S, Schultz K, Coppersmith N, Esposito A, Leeds I, Pantel H, Reddy V, Mongiu A. Association Between Chemotherapy-Induced Peripheral Neuropathy and Low Anterior Resection Syndrome. Cancers 2024, 16: 3578. DOI: 10.3390/cancers16213578.Peer-Reviewed Original ResearchLow anterior resection syndromeChemotherapy-induced peripheral neuropathyAnterior resection syndromeSystemic therapyRectal cancerPeripheral neuropathyAssociated with low anterior resection syndromeRetrospective review of patientsPlatinum-based chemotherapy agentsLow anterior resectionReview of patientsSphincter-preserving surgeryRectal cancer treatmentNeoadjuvant chemoradiationTumor distanceAnal vergeAnterior resectionRetrospective reviewChemotherapy-inducedChemotherapy agentsSide effectsCancer treatmentDebilitating conditionPatientsCIPNBy Any Other Name: Bowel Dysfunction After Proctectomy for Cancer and Its Predictive Factors in Administrative Databases
Leeds I, Coppersmith N, Moore M, Saleh A, Cruickshank K, Pantel H, Reddy V, Mongiu A. By Any Other Name: Bowel Dysfunction After Proctectomy for Cancer and Its Predictive Factors in Administrative Databases. Journal Of Surgical Research 2024, 303: 342-351. PMID: 39413695, DOI: 10.1016/j.jss.2024.09.027.Peer-Reviewed Original ResearchBowel dysfunctionRehabilitation proceduresPredictive factorsCosts of healthcare utilizationAssociated with bowel dysfunctionPopulation-based studyNeoadjuvant chemotherapy administrationLow anterior resection syndromeLow anterior resectionAdministrative claims dataRetrospective cohort studyAnterior resection syndromePostoperative bowel dysfunctionHealthcare utilizationPoisson regressionDiagnostic codesFollowed surgeryChemoradiation therapyFollow-up costsMultiagent chemotherapyStatistically significant covariatesAnterior resectionClaims dataCohort studyIndependent predictorsLong-term Outcomes Following Colectomy and Liver Transplantation for Inflammatory Bowel Disease with Primary Sclerosing Cholangitis.
Matar A, Falconer E, LaBella M, Kapadia M, Justiniano C, Olortegui K, Steinhagen R, Schultz K, Pratap A, Leeds I, Weaver L, Gaertner W, Finger E, Thompson M, Fair L, Fichera A, Lovasik B, Chapman W, McGeoch C, Camacho M, Kazimi M, Kim S, Shaffer V, Srinivasan J. Long-term Outcomes Following Colectomy and Liver Transplantation for Inflammatory Bowel Disease with Primary Sclerosing Cholangitis. Annals Of Surgery 2024 PMID: 39258375, DOI: 10.1097/sla.0000000000006533.Peer-Reviewed Original ResearchTotal abdominal colectomyLong-term outcomesIleal pouch anal anastomosisMedically refractory diseaseLiver transplantationPSC-IBDRecurrent PSCRefractory diseaseBiliary complicationsMedian timeLong-term outcomes of patientsBowel diseasePost-LT survivalOutcomes of patientsPrimary sclerosing cholangitisFraction of patientsPSC-IBD patientsLong-term survivalInflammatory bowel diseasePost-LTSclerosing cholangitisPediatric patientsAbdominal colectomyEnd ileostomyLT survivalInvited Commentary: When Less Is More: 3-day versus 7-day Selective Decontamination of the Digestive Tract Prior to Colorectal Surgery
Leeds I, Goffredo P. Invited Commentary: When Less Is More: 3-day versus 7-day Selective Decontamination of the Digestive Tract Prior to Colorectal Surgery. Journal Of Gastrointestinal Surgery 2024, 28: 1960-1961. PMID: 39265775, DOI: 10.1016/j.gassur.2024.09.005.Peer-Reviewed Original ResearchResearch Perspective on "Social Determinants of Health in Diverticulitis: A Systematic Review".
Leeds I. Research Perspective on "Social Determinants of Health in Diverticulitis: A Systematic Review". Diseases Of The Colon & Rectum 2024 PMID: 39230959, DOI: 10.1097/dcr.0000000000003469.Peer-Reviewed Original ResearchFor Whom the Bell Tolls: Assessing the Incremental Costs Associated With Failure-To-Rescue After Elective Colorectal SurgeryRunning Title: Cost of Failure-To-Rescue After Colorectal Surgery
Schultz K, Moore M, Pantel H, Mongiu A, Reddy V, Schneider E, Leeds I. For Whom the Bell Tolls: Assessing the Incremental Costs Associated With Failure-To-Rescue After Elective Colorectal SurgeryRunning Title: Cost of Failure-To-Rescue After Colorectal Surgery. Journal Of Gastrointestinal Surgery 2024, 28: 1812-1818. PMID: 39181234, DOI: 10.1016/j.gassur.2024.08.019.Peer-Reviewed Original ResearchFailure-to-rescueMedian total hospital costTotal hospital costsColorectal surgeryNational Inpatient SampleUneventful recoveryRetrospective study of adult patientsFailure-to-rescue patientsAssociated with increased healthcare costsStudy of adult patientsElective colorectal resectionHospital costsElective colorectal surgeryNationally representative cohortColorectal resectionElective colectomyPostoperative complicationsRetrospective studyAdult patientsRescue attemptsMedical futilityElective surgeryRepresentative cohortHealthcare costsPrimary outcomeSurgical Outcomes and Utilization of Laparoscopic Versus Robotic Techniques for Elective Colectomy in Asian American and Native Hawaiian-Pacific Islanders (AAPI) Diagnosed With Colon Cancer
Ahuja V, Murthy S, Leeds I, Paredes L, Su D, Tsutsumi A, Perkal M, King J. Surgical Outcomes and Utilization of Laparoscopic Versus Robotic Techniques for Elective Colectomy in Asian American and Native Hawaiian-Pacific Islanders (AAPI) Diagnosed With Colon Cancer. Journal Of Surgical Research 2024, 302: 40-46. PMID: 39083904, DOI: 10.1016/j.jss.2024.07.007.Peer-Reviewed Original ResearchLaparoscopic colectomyRobotic colectomyAAPI patientsColorectal cancerLength of stayClinical outcomesNative Hawaiian Pacific IslanderAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseOperative timeQuality Improvement Program databaseMultivariate logistic regression analysisMean operative timeColorectal cancer resectionOutcomes of LCMinimally invasive approachMultivariate logistic regressionStandard of careLogistic regression analysisElective RCElective LCAnastomotic leakElective colectomySurgical outcomesEAES/SAGES evidence-based recommendations and expert consensus on optimization of perioperative care in older adults
Keller D, Curtis N, Burt H, Ammirati C, Collings A, Polk H, Carrano F, Antoniou S, Hanna N, Piotet L, Hill S, Cuijpers A, Tejedor P, Milone M, Andriopoulou E, Kontovounisios C, Leeds I, Awad Z, Barber M, Al-Mansour M, Nassif G, West M, Pryor A, Carli F, Demartines N, Bouvy N, Passera R, Arezzo A, Francis N. EAES/SAGES evidence-based recommendations and expert consensus on optimization of perioperative care in older adults. Surgical Endoscopy 2024, 38: 4104-4126. PMID: 38942944, PMCID: PMC11289045, DOI: 10.1007/s00464-024-10977-7.Peer-Reviewed Original ResearchEvidence-based recommendationsMinimally invasive surgeryOlder adultsOlder adult patientsAbdominal surgeryColorectal surgeryPerioperative carePerioperative care of older adultsAdult patientsCare of older adultsCorrection of anemiaOptimization of perioperative careInfluence surgical outcomesCertainty of evidenceCessation of smokingEvidence synthesisExpert opinionEvidence gapsSurgical outcomesPoor outcomeFunctional capacityERAS programOlder patientsPrehabilitationMeta-analysesPersonalized risk assessment of new onset depression in long-term cancer survivors.
Taylor M, Westvold S, Long J, Hyslop T, Wang S, Cecchini M, Leapman M, Leeds I, Lustberg M, Spees L, Wheeler S, Gross C, Oeffinger K, Dinan M. Personalized risk assessment of new onset depression in long-term cancer survivors. Journal Of Clinical Oncology 2024, 42: e13798-e13798. DOI: 10.1200/jco.2024.42.16_suppl.e13798.Peer-Reviewed Original ResearchHistory of depressionIncidence of depressionCumulative incidence of depressionRisk of developing depressionLong-term survivorsPredictors of depressionCancer survivorsDisease specific factorsCumulative incidenceNon-HispanicHigher risk of developing depressionRectal cancerLong-term cancer survivorsBreast cancer survivorsCensus tract povertyColon cancerEpisodes of bipolar I disorderPrevalence of depressionMean survival time modelsDiagnosis of depressionReceipt of treatmentAssociated with prior historyHormone receptor statusPatients aged <Adjuvant endocrine therapy1224 PREOPERATIVE PSYCHOSOCIAL RISK BURDEN AMONG PATIENTS UNDEROING MAJOR THORACIC AND ABDOMINAL SURGERY
Park E, Schultz K, Pantel H, Mongiu A, Reddy V, Leeds I. 1224 PREOPERATIVE PSYCHOSOCIAL RISK BURDEN AMONG PATIENTS UNDEROING MAJOR THORACIC AND ABDOMINAL SURGERY. Gastroenterology 2024, 166: s-1850-s-1851. DOI: 10.1016/s0016-5085(24)04735-8.Peer-Reviewed Original ResearchPostoperative Outcomes Associated with the Timing of Surgery After SARS-CoV-2 Infection
Leeds I, Park L, Akgun K, Weintrob A, Justice A, King J. Postoperative Outcomes Associated with the Timing of Surgery After SARS-CoV-2 Infection. Annals Of Surgery 2024, 280: 241-247. PMID: 38323413, PMCID: PMC11236522, DOI: 10.1097/sla.0000000000006227.Peer-Reviewed Original ResearchIncreased 90-day mortalitySARS-CoV-2 infectionDays of infectionPostoperative outcomesSARS-CoV-2Increased post-operative mortalityPositive testRetrospective cohort of patientsUS Veterans Health Administration facilitiesVeterans Health Administration facilitiesPost-operative mortalityMultivariate modelTime of surgeryAdverse surgical outcomesCohort of patientsMultivariate logistic regression modelSurgical procedure groupsSARS-CoV-2 positive testDeferred surgeryPrimary endpointSurgery intervalSurgical outcomesSurgical cohortUninfected patientsASA 4
2023
The Predictors of Complete Pathologic Response in Rectal Cancer during the Total Neoadjuvant Therapy Era: A Systematic Review
Flom E, Schultz K, Pantel H, Leeds I. The Predictors of Complete Pathologic Response in Rectal Cancer during the Total Neoadjuvant Therapy Era: A Systematic Review. Cancers 2023, 15: 5853. PMID: 38136397, PMCID: PMC10742121, DOI: 10.3390/cancers15245853.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTotal neoadjuvant therapyPathologic complete responseClinical complete responseNeoadjuvant therapyComplete responseSystematic reviewRectal cancerTumor responseClinical stage 2Complete pathologic responseRetrospective cohort studyRandomized clinical trialsHeterogeneity of studiesLevel of evidenceElectronic databases EmbaseIdentification of predictorsCancer treatment paradigmLong-term trialsNeoadjuvant chemotherapyTherapy eraPatient demographicsPreoperative predictorsClinical factorsClinicopathologic factorsCohort studyMore problems, more money: Identifying and predicting high-cost rescue after colorectal surgery
Leeds I, Moore M, Schultz K, Canner J, Pantel H, Mongiu A, Reddy V, Schneider E. More problems, more money: Identifying and predicting high-cost rescue after colorectal surgery. Surgery Open Science 2023, 16: 148-154. PMID: 38026825, PMCID: PMC10656212, DOI: 10.1016/j.sopen.2023.10.007.Peer-Reviewed Original ResearchColorectal surgeryElective surgeryMedian total inpatient costsAdditional major proceduresElective colorectal surgeryPreoperative clinical predictorsCongestive heart failureGreater healthcare utilizationMultivariable Poisson regressionNational Inpatient SampleTotal inpatient costsElective colectomyCost-conscious careAdult patientsUneventful recoveryClinical predictorsHeart failureHealthcare utilizationInpatient costsSecondary proceduresInpatient SampleHealthcare costsMedian increaseSurgeryPatientsRacial disparities in complications following elective colon cancer resection: Impact of laparoscopic versus robotic approaches
Ahuja V, Paredes L, Leeds I, Perkal M, Tsutsumi A, Bhandarkar S, King J. Racial disparities in complications following elective colon cancer resection: Impact of laparoscopic versus robotic approaches. The American Journal Of Surgery 2023, 227: 85-89. PMID: 37806892, PMCID: PMC10842593, DOI: 10.1016/j.amjsurg.2023.09.038.Peer-Reviewed Original ResearchConceptsRC patientsLaparoscopic colectomyElective colon cancer resectionImpact of laparoscopicACS-NSQIP databaseColon cancer resectionMultivariable logistic regressionCancer resectionWhite patientsBlack patientsRobotic colectomyHigher complicationsOperative approachMinority patientsPatientsComplicationsColectomyLogistic regressionRobotic approachRacial disparitiesLaparoscopicCausal pathwaysLower ratesOutcomesMortalityCommentary: Machine learning in clinical decision-making
Filiberto A, Donoho D, Leeds I, Loftus T. Commentary: Machine learning in clinical decision-making. Frontiers In Digital Health 2023, 5: 1214111. PMID: 37588023, PMCID: PMC10426737, DOI: 10.3389/fdgth.2023.1214111.Peer-Reviewed Original Research