2024
Updated Analysis of Comparative Toxicity of Proton and Photon Radiation for Prostate Cancer
Yu J, DeStephano D, Jeffers B, Horowitz D, Soulos P, Gross C, Cheng S. Updated Analysis of Comparative Toxicity of Proton and Photon Radiation for Prostate Cancer. Journal Of Clinical Oncology 2024, 42: 1943-1952. PMID: 38507655, DOI: 10.1200/jco.23.01604.Peer-Reviewed Original ResearchIntensity-modulated radiation therapyProton beam therapyGU toxicityProstate cancerGI toxicityBenefits of proton beam therapyIntensity-modulated radiation therapy patientsPBT patientsLocalized prostate cancerTreatment-related toxicityComparison of GIStatistically significant differenceRadiation therapyBeam therapySEER-MedicareToxicity of protonProcedure codesComparative effectiveness studiesObservational studyPatientsSignificant differenceCancerMonthsComparing GIProstate
2023
Risk of Squamous Cell Carcinoma of the Breast Following Postmastectomy Implant Reconstruction in Women With Breast Cancer and Carcinoma in Situ
Kinslow C, Yu J, DeStephano D, Kachnic L, Cheng S, Neugut A, Horowitz D. Risk of Squamous Cell Carcinoma of the Breast Following Postmastectomy Implant Reconstruction in Women With Breast Cancer and Carcinoma in Situ. JAMA Surgery 2023, 158: 769-771. PMID: 37074722, PMCID: PMC10116379, DOI: 10.1001/jamasurg.2023.0262.Peer-Reviewed Original Research
2022
Fostering Transdisciplinary Collaborations in Cancer Health Economics Research
Yu J. Fostering Transdisciplinary Collaborations in Cancer Health Economics Research. JNCI Monographs 2022, 2022: 85-88. PMID: 35788381, DOI: 10.1093/jncimonographs/lgac001.Peer-Reviewed Original ResearchConceptsHealth economics researchCancer health economics researchEconomic researchHealth economicsHealth-care providersHealth-care decisionsComprehensive research questionsTransdisciplinary collaborationPotential facilitatorsParticipants' discussionsMultifaceted determinantsEconomic theoryEffective collaborationHealthEmpirical techniquesDomains of knowledgeEconomicsCollaborationCancerPanelResearch questionsProvidersParticipantsFacilitationQuestionsHealth Economics Research in Cancer Treatment: Current Challenges and Future Directions
Yu J, Schrag D, Yabroff K. Health Economics Research in Cancer Treatment: Current Challenges and Future Directions. JNCI Monographs 2022, 2022: 51-56. PMID: 35788370, DOI: 10.1093/jncimonographs/lgac009.Peer-Reviewed Original ResearchConceptsHealth economics researchMeasures of social determinants of healthCancer health economics researchNational Cancer Institute's Division of Cancer Control and Population SciencesSocial determinants of healthCost of cancer careDivision of Cancer Control and Population SciencesDeterminants of healthHealth-care systemStudies of cancer treatmentCancer treatmentCancer careIntegration of economic analysisInsurance typeHealth economistsPopulation scienceProspective economic studyHealthArea of focusWorkgroupStandard evaluationEconomic researchCancerCareClinical trials
2021
National Quality Measure Compliance for Palliative Bone Radiation Among Patients With Metastatic Non-Small Cell Lung Cancer.
Grant S, Smith B, Colbert L, Nguyen Q, Yu J, Lin S, Chen A. National Quality Measure Compliance for Palliative Bone Radiation Among Patients With Metastatic Non-Small Cell Lung Cancer. Journal Of The National Comprehensive Cancer Network 2021, 19: 1-6. PMID: 34044365, DOI: 10.6004/jnccn.2020.7688.Peer-Reviewed Original ResearchNon-small cell lung cancerCell lung cancerMetastatic non-small cell lung cancerTreatment courseLung cancerBone metastasesSite of metastatic diseaseNational Cancer DatabaseYear of diagnosisNational Quality ForumMetastatic diseaseRadiation therapyPalliative radiationCancer DatabaseBone radiationTreatment characteristicsMultivariate analysisTreatment scheduleRate of complianceRecommended scheduleBony sitesPatientsShort courseCancerAcademic facilitiesPrevalence of Missing Data in the National Cancer Database and Association With Overall Survival
Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNon-small cell lung cancerOverall survivalCell lung cancerCancer DatabaseMedical recordsLung cancerProstate cancerBreast cancerPatient recordsComplete dataRetrospective cohort studyCohort studyCancer RegistryCommon cancerVariables of interestHigh prevalenceMAIN OUTCOMEPatientsClinical advancementReal-world data sourcesCancerPrevalenceSurvivalHeterogeneous differences
2020
Association Between Prophylactic Cranial Irradiation and Improved Overall Survival in Small Cell Lung Cancer
Yang D, Park H, Jairam V, Decker R, Chiang A, Gross C, Yu J. Association Between Prophylactic Cranial Irradiation and Improved Overall Survival in Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2020, 108: e106. DOI: 10.1016/j.ijrobp.2020.07.1223.Peer-Reviewed Original ResearchAssociation Between Percentage of Positive Biopsy Cores and Risk of Pelvic Lymph Node Involvement in Prostate Cancer
Yang D, Dee E, Arega M, Nguyen P, Orio P, King M, Kann B, Yu J, Sandler K, Ma T, Kishan A, Muralidhar V. Association Between Percentage of Positive Biopsy Cores and Risk of Pelvic Lymph Node Involvement in Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2020, 108: e860. DOI: 10.1016/j.ijrobp.2020.07.427.Peer-Reviewed Original ResearchRadiation Dose to the Rectum With Definitive Radiation Therapy and Hydrogel Spacer Versus Postprostatectomy Radiation Therapy
Yang DX, Verma V, An Y, Yu JB, Sprenkle PC, Leapman MS, Park HS. Radiation Dose to the Rectum With Definitive Radiation Therapy and Hydrogel Spacer Versus Postprostatectomy Radiation Therapy. Advances In Radiation Oncology 2020, 5: 1225-1231. PMID: 33305083, PMCID: PMC7718530, DOI: 10.1016/j.adro.2020.08.015.Peer-Reviewed Original ResearchDefinitive radiation therapyPostoperative radiation therapyHydrogel spacerRadiation therapyRectal dosimetryProstate cancerGroup 1Rectal dose-volume parametersPostprostatectomy radiation therapyDose-volume parametersPostprostatectomy settingSurgical patientsPrimary managementRectal volumeDefinitive settingRadical prostatectomyRectal dosesGroup 2High riskPatientsLinear regression analysisProstatectomyMann-WhitneyTherapyCancerTrends in Use and Comparison of Stereotactic Body Radiation Therapy, Brachytherapy, and Dose-Escalated External Beam Radiation Therapy for the Management of Localized, Intermediate-Risk Prostate Cancer
Nguyen KA, Lee A, Patel SA, Chakravorty A, Yu JB, Kishan AU, Chang AJ. Trends in Use and Comparison of Stereotactic Body Radiation Therapy, Brachytherapy, and Dose-Escalated External Beam Radiation Therapy for the Management of Localized, Intermediate-Risk Prostate Cancer. JAMA Network Open 2020, 3: e2017144. PMID: 32970153, PMCID: PMC7516602, DOI: 10.1001/jamanetworkopen.2020.17144.Peer-Reviewed Original ResearchConceptsStereotactic body radiation therapyBody radiation therapyRadiation therapyProstate cancerIntermediate-risk prostate cancerExternal beam radiation therapyManagement of LocalizedExternal beam radiotherapyUse of brachytherapyBeam radiation therapyCohort studyBeam radiotherapyTherapyDisease managementCancerBrachytherapyPatientsRadiotherapyNational Patterns in Prescription Opioid Use and Misuse Among Cancer Survivors in the United States
Jairam V, Yang DX, Verma V, Yu JB, Park HS. National Patterns in Prescription Opioid Use and Misuse Among Cancer Survivors in the United States. JAMA Network Open 2020, 3: e2013605. PMID: 32804217, PMCID: PMC7431994, DOI: 10.1001/jamanetworkopen.2020.13605.Peer-Reviewed Original ResearchConceptsPrescription opioid usePrescription opioid misuseRecent cancer survivorsOpioid useCancer survivorsAdult cancer survivorsOpioid misuseUse disordersHigher prescription opioid useRecent cancer historyCancer-related painHistory of cancerPopulation-based studyNonmelanoma skin cancerDrug use disordersCross-sectional studyAlcohol use disorderLong-term misusePrescription opioidsCancer historyMAIN OUTCOMESkin cancerDrug useYounger ageCancerDid quality of life for older cancer survivors improve with the turn of the century in the United States?
Mahal AR, Cramer LD, Wang EH, Wang S, Davidoff AJ, Gross CP, Yu JB. Did quality of life for older cancer survivors improve with the turn of the century in the United States? Journal Of Geriatric Oncology 2020, 12: 102-105. PMID: 32535014, DOI: 10.1016/j.jgo.2020.05.010.Peer-Reviewed Original ResearchConceptsPhysical component summaryMental component summary scoresComponent summary scoresHealth utilityOlder patientsComponent summaryCancer survivorsLung cancerSummary scoresEarly era patientsLung cancer survivorsHealth-related qualityOlder cancer survivorsPopulation-based registryMedicare Advantage patientsLater eraQuality of lifeERA patientsAdvantage patientsMean agePatientsLongitudinal patientSimilar outcomesPropensity scoreCancerGeographic-Level Association of Contemporary Changes in Localized and Metastatic Prostate Cancer Incidence in the Era of Decreasing PSA Screening
Yang DX, Makarov DV, Gross CP, Yu JB. Geographic-Level Association of Contemporary Changes in Localized and Metastatic Prostate Cancer Incidence in the Era of Decreasing PSA Screening. Cancer Control 2020, 27: 1073274820902267. PMID: 32003227, PMCID: PMC7003204, DOI: 10.1177/1073274820902267.Peer-Reviewed Original ResearchConceptsMetastatic prostate cancer incidenceProstate cancer incidenceHealth care service areasMetastatic diseaseCancer incidenceNational Cancer Institute's SurveillanceEnd Results (SEER) databaseLocalized prostate cancerSEER 18 registriesProstate-specific antigenPSA screeningLocalized diseaseResults databaseProstate cancerOlder menMetastatic incidenceIncidenceDiseaseDiagnosisLate changesMenRecent increaseAssociationRegistryCancer
2019
Early Impact of the Affordable Care Act and Medicaid Expansion on Racial and Socioeconomic Disparities in Cancer Care
Mahal A, Chavez J, Yang D, Kim D, Cole A, Hu J, Trinh Q, Yu J, Nguyen P, Mahal B. Early Impact of the Affordable Care Act and Medicaid Expansion on Racial and Socioeconomic Disparities in Cancer Care. American Journal Of Clinical Oncology 2019, 43: 163-167. PMID: 31904711, DOI: 10.1097/coc.0000000000000588.Peer-Reviewed Original ResearchConceptsAffordable Care ActAffordable Care Act implementationMedicaid expansionUninsured rateCare ActInsurance coverageInsurance coverage gapsMultivariate logistic regressionCoverage gapSocioeconomic disparitiesCare objectivesSociodemographic disparitiesRacial disparitiesLow-incomeNonelderly adultsLogistic regressionMedicaidBlack patientsDisparitiesEarly impactInsurancePotential benefitsPatientsCancerAffordabilityCost-Effectiveness of Prostate Radiation Therapy in Men with Newly Diagnosed Low Burden Metastatic Prostate Cancer
Lester-Coll N, Ades S, Yu J, Atherly A, Wallace H, Sprague B. Cost-Effectiveness of Prostate Radiation Therapy in Men with Newly Diagnosed Low Burden Metastatic Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2019, 105: s180-s181. DOI: 10.1016/j.ijrobp.2019.06.221.Peer-Reviewed Original ResearchStereotactic Body Radiation Therapy Vs Hypofractionated Intensity Modulated Radiation Therapy for Localized Prostate Cancer (SHRAPNEL): An International Meta-Analysis of 24 Prospective Trials
Lehrer E, Kishan A, Yu J, Trifiletti D, Showalter T, Ellis R, Zaorsky N. Stereotactic Body Radiation Therapy Vs Hypofractionated Intensity Modulated Radiation Therapy for Localized Prostate Cancer (SHRAPNEL): An International Meta-Analysis of 24 Prospective Trials. International Journal Of Radiation Oncology • Biology • Physics 2019, 105: e289. DOI: 10.1016/j.ijrobp.2019.06.1829.Peer-Reviewed Original ResearchConservative management of low‐risk prostate cancer among young versus older men in the United States: Trends and outcomes from a novel national database
Mahal A, Butler S, Franco I, Muralidhar V, Larios D, Pike L, Zhao S, Sanford N, Dess R, Feng F, D’Amico A, Spratt D, Yu J, Nguyen P, Rebbeck T, Mahal B. Conservative management of low‐risk prostate cancer among young versus older men in the United States: Trends and outcomes from a novel national database. Cancer 2019, 125: 3338-3346. PMID: 31251398, DOI: 10.1002/cncr.32332.Peer-Reviewed Original ResearchConceptsLow-risk prostate cancerPositive biopsy coresShort-term outcomesBiopsy coresProstate cancerManagement of low-risk prostate cancerOlder patientsProstate cancer-specific mortality ratesConservative managementProstate cancer-specific mortalityCancer-specific mortality ratesActive surveillance/watchful waitingRate of conservative managementOlder menCancer-specific mortalityShort-term safetyQuality-of-life implicationsDefinitive treatmentYounger patientsOverall mortalityPatientsMortality rateProstateNational databaseCancerContemporary changes in localized and metastatic prostate cancer incidence by geographic area following decreased PSA screening.
Yang D, Makarov D, Gross C, Yu J. Contemporary changes in localized and metastatic prostate cancer incidence by geographic area following decreased PSA screening. Journal Of Clinical Oncology 2019, 37: 1567-1567. DOI: 10.1200/jco.2019.37.15_suppl.1567.Peer-Reviewed Original ResearchProstate cancer incidenceHealth service areasMetastatic prostate cancerMetastatic prostate cancer incidenceMetastatic diseaseCancer incidenceProstate cancerLocalized diseasePopulation-weighted linear regressionMen 70 yearsEnd Results (SEER) databaseHealth Service regionResults databaseIncidence rateHospital careMetastatic incidenceIncidenceDiseaseCancerLate increasePSALinear regressionMenTemporal relationshipSurveillanceMP29-16 THE ASSOCIATION BETWEEN THE AFFORDABLE CARE ACT, INSURANCE STATUS, AND TREATMENT AMONG PATIENTS WITH TESTICULAR CANCER
Hsiang W, Jemal A, Nguyen K, Shuch B, Park H, Yu J, Gross C, Davidoff A, Leapman* M. MP29-16 THE ASSOCIATION BETWEEN THE AFFORDABLE CARE ACT, INSURANCE STATUS, AND TREATMENT AMONG PATIENTS WITH TESTICULAR CANCER. Journal Of Urology 2019, 201 DOI: 10.1097/01.ju.0000557551.36748.5c.Peer-Reviewed Original ResearchPV-0045 Is proton therapy a "pro" for breast cancer? A comparison of proton vs. non-proton RT using the NCDB
Chowdhary M, Lee A, Gao S, Barry P, Diaz R, Bagadiya N, Park H, Yu J, Wilson L, Moran M, Higgins S, Knowlton C, Patel K. PV-0045 Is proton therapy a "pro" for breast cancer? A comparison of proton vs. non-proton RT using the NCDB. Radiotherapy And Oncology 2019, 133: s15. DOI: 10.1016/s0167-8140(19)30465-7.Peer-Reviewed Original Research