2008
A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells
Li H, Wang J, Mor G, Sklar J. A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells. Science 2008, 321: 1357-1361. PMID: 18772439, DOI: 10.1126/science.1156725.Peer-Reviewed Original ResearchMeSH KeywordsCell HypoxiaCell LineCell Line, TumorChromosome AberrationsChromosomes, Human, Pair 17Chromosomes, Human, Pair 7Co-Repressor ProteinsDeferoxamineDNA-Binding ProteinsEndometrial NeoplasmsEndometriumExonsFemaleGene FusionHumansMenstrual CycleMutant Chimeric ProteinsNeoplasm ProteinsProgesteroneProtein BiosynthesisRNA PrecursorsRNA, MessengerStromal CellsTranscription FactorsTranslocation, GeneticTrans-SplicingConceptsGene fusionsChimeric RNAsPrecursor messenger RNAChimeric gene productsResultant chimeric transcriptsTrans splicingNormal human cellsAnti-apoptotic activityChromosome 7p15Gene productsChromosomal rearrangementsChromosome 17q11JAZF1 geneHuman cellsTumor-specific productsRNANormal endometrial stromal cellsChimeric transcriptsMessenger RNAExonsProteinHuman tumorsStromal cellsEndometrial stromal cellsCells
1989
Detection of Epstein–Barr Viral Genomes in Reed–Sternberg Cells of Hodgkin's Disease
Weiss LM, Movahed LA, Warnke RA, Sklar J. Detection of Epstein–Barr Viral Genomes in Reed–Sternberg Cells of Hodgkin's Disease. New England Journal Of Medicine 1989, 320: 502-506. PMID: 2536894, DOI: 10.1056/nejm198902233200806.Peer-Reviewed Original ResearchConceptsReed-Sternberg cellsEpstein-Barr virusHodgkin's diseaseSlot blot hybridizationEBV genomeBiopsy tissueTissue specimensEpstein-Barr viral genomeEBV nucleic acidsBlot hybridizationEBV DNASitu hybridizationSouthern blot hybridizationPositive specimensDiseasePatientsInfected cellsTissueIntense hybridizationSuch tissuesCellsViral genomePrevious studiesMonoclonality