Featured Publications
Comparative Effectiveness of Machine Learning Approaches for Predicting Gastrointestinal Bleeds in Patients Receiving Antithrombotic Treatment
Herrin J, Abraham NS, Yao X, Noseworthy PA, Inselman J, Shah ND, Ngufor C. Comparative Effectiveness of Machine Learning Approaches for Predicting Gastrointestinal Bleeds in Patients Receiving Antithrombotic Treatment. JAMA Network Open 2021, 4: e2110703. PMID: 34019087, PMCID: PMC8140376, DOI: 10.1001/jamanetworkopen.2021.10703.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAnticoagulantsAntifibrinolytic AgentsAtrial FibrillationClinical Decision-MakingCohort StudiesCross-Sectional StudiesFemaleFibrinolytic AgentsGastrointestinal HemorrhageHumansMachine LearningMaleMiddle AgedMyocardial IschemiaPredictive Value of TestsRetrospective StudiesRisk AssessmentThienopyridinesUnited StatesVenous ThromboembolismYoung AdultConceptsGastrointestinal bleedingIschemic heart diseaseCross-sectional studyThienopyridine antiplatelet agentAntithrombotic treatmentVenous thromboembolismAntiplatelet agentsRandom survival forestStudy cohortAtrial fibrillationValidation cohortHeart diseaseHAS-BLED risk scoreRetrospective cross-sectional studyCox proportional hazards regressionHAS-BLED scorePrior GI bleedPatients 18 yearsCohort of patientsEntire study cohortProportional hazards regressionOptumLabs Data WarehouseMedicare Advantage enrolleesPositive predictive valueRisk prediction model
2022
Trends and Variation in the Gap Between Current and Anticipated Life Satisfaction in the United States, 2008-2020.
Riley C, Herrin J, Lam V, Parsons AA, Kaplan GA, Liu D, Witters D, Krumholz HM, Roy B. Trends and Variation in the Gap Between Current and Anticipated Life Satisfaction in the United States, 2008-2020. American Journal Of Public Health 2022, 112: 509-517. PMID: 35196041, PMCID: PMC8887183, DOI: 10.2105/ajph.2021.306589.Peer-Reviewed Original Research
2021
National Trends in Racial and Ethnic Disparities in Antihypertensive Medication Use and Blood Pressure Control Among Adults With Hypertension, 2011–2018
Lu Y, Liu Y, Dhingra LS, Massey D, Caraballo C, Mahajan S, Spatz ES, Onuma O, Herrin J, Krumholz HM. National Trends in Racial and Ethnic Disparities in Antihypertensive Medication Use and Blood Pressure Control Among Adults With Hypertension, 2011–2018. Hypertension 2021, 79: 207-217. PMID: 34775785, DOI: 10.1161/hypertensionaha.121.18381.Peer-Reviewed Original ResearchConceptsAntihypertensive medication usePoor hypertension controlOverall treatment rateLow control rateHypertension controlHypertension awarenessMedication useControl rateHispanic individualsEthnic differencesTreatment ratesBlack individualsGuideline-recommended medicationsBlood pressure controlWhite individualsNutrition Examination SurveyLow awareness rateAntihypertensive medicationsHypertensive peopleExamination SurveyIntensive medicationNational HealthAwareness rateEthnic disparitiesPressure controlTrends in Differences in Health Status and Health Care Access and Affordability by Race and Ethnicity in the United States, 1999-2018
Mahajan S, Caraballo C, Lu Y, Valero-Elizondo J, Massey D, Annapureddy AR, Roy B, Riley C, Murugiah K, Onuma O, Nunez-Smith M, Forman HP, Nasir K, Herrin J, Krumholz HM. Trends in Differences in Health Status and Health Care Access and Affordability by Race and Ethnicity in the United States, 1999-2018. JAMA 2021, 326: 637-648. PMID: 34402830, PMCID: PMC8371573, DOI: 10.1001/jama.2021.9907.Peer-Reviewed Original ResearchConceptsHealth care accessFair health statusSelf-reported health statusCare accessHealth statusWhite individualsEthnic differencesLatino/HispanicNational Health Interview Survey dataSerial cross-sectional studySelf-reported functional limitationsBlack individualsHealth Interview Survey dataLow incomeCross-sectional studyCross-sectional survey studyInterview Survey dataSelf-reported raceSelf-report measuresMAIN OUTCOMEUS adultsFunctional limitationsPercentage of peopleSignificant decreaseAdults
2019
Do pregnant women living in higher well-being populations in the USA experience lower risk of preterm delivery? A cross-sectional study
Riley C, Roy B, Herrin J, Spatz E, Silvestri MT, Arora A, Kell KP, Rula EY, Krumholz HM. Do pregnant women living in higher well-being populations in the USA experience lower risk of preterm delivery? A cross-sectional study. BMJ Open 2019, 9: e024143. PMID: 31048427, PMCID: PMC6501974, DOI: 10.1136/bmjopen-2018-024143.Peer-Reviewed Original ResearchConceptsPreterm birthCross-sectional studyIndividual risk factorsPreterm deliveryRisk factorsPregnant womenLower riskMaternal risk factorsPrimary outcome measurePrimary independent variableGestational ageMaternal riskOutcome measuresUS birthsHealth StatisticsBirth dataBeing IndexWomenBirthGallup-Sharecare WellLower ratesQuintileRiskDeliveryPopulationA Prognostic Index to Identify the Risk of Developing Depression Symptoms Among U.S. Medical Students Derived From a National, Four-Year Longitudinal Study
Dyrbye LN, Wittlin NM, Hardeman RR, Yeazel M, Herrin J, Dovidio JF, Burke SE, Cunningham B, Phelan SM, Shanafelt TD, van Ryn M. A Prognostic Index to Identify the Risk of Developing Depression Symptoms Among U.S. Medical Students Derived From a National, Four-Year Longitudinal Study. Academic Medicine 2019, 94: 217-226. PMID: 30188367, DOI: 10.1097/acm.0000000000002437.Peer-Reviewed Original ResearchConceptsRisk groupsBaseline depression symptomsPrognostic indexDepression symptomsIndependent prognostic factorHigh-risk groupLow-risk groupSocial supportPrimary prevention approachReplication datasetU.S. medical studentsBaseline factorsPrognostic factorsC-statisticOdds ratioMedical studentsMultivariate analysisSymptomsBaseline individualDepressionPrevention approachesLongitudinal studyMedical schoolsRiskDiscovery dataset
2018
Risk of Systemic Adverse Events Associated with Intravitreal Anti–VEGF Therapy for Diabetic Macular Edema in Routine Clinical Practice
Maloney MH, Schilz SR, Herrin J, Sangaralingham LR, Shah ND, Barkmeier AJ. Risk of Systemic Adverse Events Associated with Intravitreal Anti–VEGF Therapy for Diabetic Macular Edema in Routine Clinical Practice. Ophthalmology 2018, 126: 1007-1015. PMID: 30292542, DOI: 10.1016/j.ophtha.2018.09.040.Peer-Reviewed Original ResearchConceptsDiabetic macular edemaRoutine clinical practiceSystemic serious adverse eventsMacular laserMajor bleedingCerebrovascular diseaseMyocardial infarctionClinical practiceCause hospitalizationAdverse eventsHazard ratioIntravitreal corticosteroidsAnti-VEGFMacular edemaDME treatmentTreatment of DMEIntravitreal anti-VEGF therapyCox proportional hazards regressionAnti-VEGF pharmacotherapySystemic safety profileCorticosteroid-treated patientsRetrospective cohort studySerious adverse eventsSystemic adverse eventsMacular laser photocoagulationIdentifying county characteristics associated with resident well-being: A population based study
Roy B, Riley C, Herrin J, Spatz ES, Arora A, Kell KP, Welsh J, Rula EY, Krumholz HM. Identifying county characteristics associated with resident well-being: A population based study. PLOS ONE 2018, 13: e0196720. PMID: 29791476, PMCID: PMC5965855, DOI: 10.1371/journal.pone.0196720.Peer-Reviewed Original ResearchConceptsCounty-level factorsClinical careCross-sectional studyQuality of lifeBetter health outcomesMulti-dimensional assessmentHealth outcomesBeing IndexGallup-Sharecare WellUS residentsCareCounty characteristicsSurvey participantsResident wellUS countiesScoresCounty equivalentsAssessmentFactorsCohort
2017
Predictors of Return Visits Among Insured Emergency Department Mental Health and Substance Abuse Patients, 2005-2013
Lee S, Herrin J, Bobo WV, Johnson R, Sangaralingham LR, Campbell RL. Predictors of Return Visits Among Insured Emergency Department Mental Health and Substance Abuse Patients, 2005-2013. Western Journal Of Emergency Medicine 2017, 18: 884-893. PMID: 28874941, PMCID: PMC5576625, DOI: 10.5811/westjem.2017.6.33850.Peer-Reviewed Original ResearchConceptsED visitsReturn visitsInpatient admissionsOptum Labs Data WarehouseMental healthChronic medical comorbiditiesContinuous insurance enrollmentFirst ED visitIndex ED visitRetrospective cohort studyAdministrative claims dataMedicare Advantage enrolleesPrior EDMedical comorbiditiesCohort studyAcute carePrimary diagnosisStudy inclusionRisk factorsInpatient utilizationClaims dataIncreased ageSubstance abusePatientsStudy periodImpact of treatment regimen on acute care use during and after adjuvant chemotherapy for early-stage breast cancer
Ruddy KJ, Van Houten HK, Sangaralingham LR, Freedman RA, Thompson CA, Hashmi SK, Jemal A, Haddad TC, Mougalian S, Herrin J, Gross C, Shah N. Impact of treatment regimen on acute care use during and after adjuvant chemotherapy for early-stage breast cancer. Breast Cancer Research And Treatment 2017, 164: 515-525. PMID: 28493045, DOI: 10.1007/s10549-017-4280-y.Peer-Reviewed Original ResearchConceptsAcute care useEarly-stage breast cancerCare useBreast cancerAdjuvant chemotherapyContemporary adjuvant chemotherapyAcute care needsCommercial insurance databaseEmergency department visitsED visit ratesRate of hospitalizationOncology Care ModelChemotherapy initiationChemotherapy regimenEligible patientsED visitsDepartment visitsTreatment regimenAcute careInsurance databaseAdministration periodAdjusted ratesCare modelCare needsVisit rates
2016
Thermography Examination of Abdominal Area Skin Temperatures in Individuals With and Without Focal-Onset Epilepsy
King HH, Cayce CT, Herrin J. Thermography Examination of Abdominal Area Skin Temperatures in Individuals With and Without Focal-Onset Epilepsy. Explore: The Journal Of Science & Healing 2016, 13: 46-52. PMID: 27876238, DOI: 10.1016/j.explore.2016.10.003.Peer-Reviewed Original ResearchConceptsFocal onset epilepsyControl groupAbdominal areaControl subjectsViscero-somatic reflexesHistory of epilepsySignificant differencesSignificant demographic differencesTotal abdominal areaMechanism of actionAbdominal epilepsyAbdominal injuriesExperimental patientsEpilepsy groupEpileptic pathologyMore quadrantsEpileptic patientsWarrants further considerationVisceral structuresEpilepsyAbdominal adhesionsEpilepsy FoundationPatientsPresent study resultsNeurological interactionsTrends in Drug Utilization, Glycemic Control, and Rates of Severe Hypoglycemia, 2006–2013
Lipska KJ, Yao X, Herrin J, McCoy RG, Ross JS, Steinman MA, Inzucchi SE, Gill TM, Krumholz HM, Shah ND. Trends in Drug Utilization, Glycemic Control, and Rates of Severe Hypoglycemia, 2006–2013. Diabetes Care 2016, 40: 468-475. PMID: 27659408, PMCID: PMC5360291, DOI: 10.2337/dc16-0985.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBlood GlucoseComorbidityDiabetes Mellitus, Type 2Dipeptidyl-Peptidase IV InhibitorsDrug UtilizationFemaleGlycated HemoglobinHumansHypoglycemiaHypoglycemic AgentsInsulinLogistic ModelsMaleMetforminMiddle AgedRetrospective StudiesSulfonylurea CompoundsThiazolidinedionesYoung AdultConceptsGlycemic controlSevere hypoglycemiaOlder patientsDipeptidyl peptidase-4 inhibitorsGlucose-lowering drugsGlucose-lowering medicationsProportion of patientsOverall glycemic controlPeptidase-4 inhibitorsMedicare Advantage patientsSex-standardized ratesType 2 diabetesOverall rateClass of agentsMore comorbiditiesChronic comorbiditiesYounger patientsAdvantage patientsDrug utilizationClaims dataPatientsHypoglycemiaHemoglobin AT2DMComorbidities
2015
Medical School Experiences Associated with Change in Implicit Racial Bias Among 3547 Students: A Medical Student CHANGES Study Report
van Ryn M, Hardeman R, Phelan SM, PhD D, Dovidio JF, Herrin J, Burke SE, Nelson DB, Perry S, Yeazel M, Przedworski JM. Medical School Experiences Associated with Change in Implicit Racial Bias Among 3547 Students: A Medical Student CHANGES Study Report. Journal Of General Internal Medicine 2015, 30: 1748-1756. PMID: 26129779, PMCID: PMC4636581, DOI: 10.1007/s11606-015-3447-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttitude of Health PersonnelBlack or African AmericanCurriculumEducation, Medical, UndergraduateFemaleHealthcare DisparitiesHumansInterprofessional RelationsLongitudinal StudiesMaleMiddle AgedPhysician-Patient RelationsRacismSchools, MedicalSocioeconomic FactorsStudents, MedicalYoung AdultConceptsMedical schoolsSelf-assessed skillsBlack-White Implicit Association TestSchool experiencesLast semesterMedical school experienceU.S. medical schoolsImplicit racial attitudesRole model behaviorsInformal curriculumRacial biasFormal curriculumStudent reportsFirst semesterMedical educationRacial attitudesRacial climateImplicit racial biasSchoolsAfrican American physiciansCultural competenceSemesterCurriculumNegative commentsStudentsChanging trends in type 2 diabetes mellitus treatment intensification, 2002-2010.
McCoy RG, Zhang Y, Herrin J, Denton BT, Mason JE, Montori VM, Smith SA, Shah ND. Changing trends in type 2 diabetes mellitus treatment intensification, 2002-2010. The American Journal Of Managed Care 2015, 21: e288-96. PMID: 26167776.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdolescentAdultAge FactorsAgedBlood GlucoseComorbidityDiabetes Mellitus, Type 2Drug Therapy, CombinationFemaleGlycated HemoglobinHumansHypoglycemic AgentsIncretinsInsurance Claim ReviewMaleMetforminMiddle AgedResidence CharacteristicsRetrospective StudiesSex FactorsSocioeconomic FactorsSulfonylurea CompoundsUnited StatesYoung AdultConceptsTreatment intensificationCox proportional hazards regression analysisNational administrative data setProportional hazards regression analysisRetrospective secondary data analysisDiabetes treatment intensificationOptimal diabetes careHazards regression analysisDiabetes-related complicationsAdults 18 yearsTreatment-naïve adultsNon-Hispanic whitesComorbidity burdenMetformin monotherapySulfonylurea useMetformin prescriptionThiazolidinedione useGlycemic controlKaplan-MeierMean ageDiabetes careSignificant confoundersSecondary data analysisAdministrative data setsDiabetes therapy
2013
Association between physicians’ experience after training and maternal obstetrical outcomes: cohort study
Epstein AJ, Srinivas SK, Nicholson S, Herrin J, Asch DA. Association between physicians’ experience after training and maternal obstetrical outcomes: cohort study. The BMJ 2013, 346: f1596. PMID: 23538919, PMCID: PMC3610558, DOI: 10.1136/bmj.f1596.Peer-Reviewed Original ResearchConceptsMaternal complication ratesMaternal complicationsComplication rateRetrospective cohort analysisAcute care hospitalsObstetrical outcomesCesarean deliveryCohort studyCare hospitalVaginal deliveryCesarean birthCompletion of residencyCohort analysisPhysician yearsMAIN OUTCOMEThird decadePost-residency practiceComplicationsObstetriciansMore yearsSecular trendsComposite measurePercentage pointsAssociationSecond decade
2011
National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention
Herrin J, Miller LE, Turkmani DF, Nsa W, Drye EE, Bernheim SM, Ling SM, Rapp MT, Han LF, Bratzler DW, Bradley EH, Nallamothu BK, Ting HH, Krumholz HM. National Performance on Door-In to Door-Out Time Among Patients Transferred for Primary Percutaneous Coronary Intervention. JAMA Internal Medicine 2011, 171: 1879-1886. PMID: 22123793, PMCID: PMC4312661, DOI: 10.1001/archinternmed.2011.481.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionDIDO timeCoronary interventionST-segment elevation acute myocardial infarctionMixed-effects multivariable modelElevation acute myocardial infarctionPrimary percutaneous coronary interventionMedian DIDO timeAcute myocardial infarctionFibrinolytic therapyPatient characteristicsMultivariable analysisEmergency departmentMyocardial infarctionHospital characteristicsMultivariable modelPatientsRural hospitalsHospitalMedicaid ServicesAge categoriesInterventionAfrican AmericansMinutesTreatment timeImprovements in Door-to-Balloon Time in the United States, 2005 to 2010
Krumholz HM, Herrin J, Miller LE, Drye EE, Ling SM, Han LF, Rapp MT, Bradley EH, Nallamothu BK, Nsa W, Bratzler DW, Curtis JP. Improvements in Door-to-Balloon Time in the United States, 2005 to 2010. Circulation 2011, 124: 1038-1045. PMID: 21859971, PMCID: PMC3598634, DOI: 10.1161/circulationaha.111.044107.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPercutaneous coronary interventionBalloon timeCoronary interventionMedian timeST-segment elevation myocardial infarctionHigher median timeCharacteristics of patientsPercentage of patientsTimeliness of treatmentYears of ageRegistry studyMyocardial infarctionInpatient measuresPatientsHospital groupMedicaid ServicesCalendar yearInterventionMinutesMedianGroupYearsPercentageInfarctionAccess and quality of rural healthcare: Ethiopian Millennium Rural Initiative
Bradley E, Thompson JW, Byam P, Webster TR, Zerihun A, Alpern R, Herrin J, Abebe Y, Curry L. Access and quality of rural healthcare: Ethiopian Millennium Rural Initiative. International Journal For Quality In Health Care 2011, 23: 222-230. PMID: 21467077, DOI: 10.1093/intqhc/mzr013.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedCommunity Health CentersDelivery of Health CareDelivery, ObstetricEthiopiaFemaleHealth Services AccessibilityHealth Services Needs and DemandHIV InfectionsHumansLongitudinal StudiesMaleMiddle AgedPostnatal CarePrenatal CareQuality of Health CareRural PopulationYoung AdultConceptsPrimary healthcare unitsAntenatal care coverageHealth centersAntenatal careCare coverageHealth post levelOutpatient visit ratesHealthcare unitsHealthcare servicesHealth postsRural careUnmet needVisit ratesHIVFocus group participantsRural initiativesOutpatient volumeSystems-based approachGroup participantsRural settingsCareSignificant increaseRural healthcare servicesRural healthcareFocus group data
2009
The Effect of Alternative Graphical Displays Used to Present the Benefits of Antibiotics for Sore Throat on Decisions about Whether to Seek Treatment: A Randomized Trial
Carling CL, Kristoffersen DT, Flottorp S, Fretheim A, Oxman AD, Schünemann HJ, Akl EA, Herrin J, MacKenzie TD, Montori VM. The Effect of Alternative Graphical Displays Used to Present the Benefits of Antibiotics for Sore Throat on Decisions about Whether to Seek Treatment: A Randomized Trial. PLOS Medicine 2009, 6: e1000140. PMID: 19707579, PMCID: PMC2726763, DOI: 10.1371/journal.pmed.1000140.Peer-Reviewed Original ResearchConceptsSore throatVisual analog scaleBenefits of antibioticsVAS scoresRelative importance scoresDay threeDuration of symptomsTreatment effectsConsequence of treatmentProportion of peopleDetailed patient informationAntibiotic prescriptionsSymptom reliefRandomized trialsAnalog scaleAdult volunteersHealth programsSymptomsLogistic regressionAverage durationPatient informationMost participantsTrialsAntibioticsSignificant differencesThe Effect of Alternative Summary Statistics for Communicating Risk Reduction on Decisions about Taking Statins: A Randomized Trial
Carling CL, Kristoffersen DT, Montori VM, Herrin J, Schünemann HJ, Treweek S, Akl EA, Oxman AD. The Effect of Alternative Summary Statistics for Communicating Risk Reduction on Decisions about Taking Statins: A Randomized Trial. PLOS Medicine 2009, 6: e1000134. PMID: 19707575, PMCID: PMC2724738, DOI: 10.1371/journal.pmed.1000134.Peer-Reviewed Original Research