2017
Chapter Two A Chemoattractant-Guided Walk Through Lymphopoiesis From Hematopoietic Stem Cells to Mature B Lymphocytes
Lim VY, Zehentmeier S, Fistonich C, Pereira JP. Chapter Two A Chemoattractant-Guided Walk Through Lymphopoiesis From Hematopoietic Stem Cells to Mature B Lymphocytes. Advances In Immunology 2017, 134: 47-88. PMID: 28413023, PMCID: PMC5784265, DOI: 10.1016/bs.ai.2017.02.001.Peer-Reviewed Original ResearchConceptsHematopoietic stem cellsBone marrow parenchymaProgenitor cellsCell motility machinerySpecialized bone marrow nichesMarrow parenchymaStem cellsMultipotent progenitor cellsCommon lymphoid progenitor cellsStem/progenitor cellsBone marrow nicheBone marrow sinusoidsMotility machineryMature B cell poolStem cell factorLymphoid progenitor cellsEndothelial cellsMature B lymphocytesBCR signalingInterleukin-7Multilineage differentiationMarrow nicheHematopoietic cellsCell factorMarrow sinusoids
2016
Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation
Gomes A, Hara T, Lim VY, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-ichi S, Schlenner S, Richie E, Rodewald HR, Flavell RA, Nagasawa T, Ikuta K, Pereira JP. Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. Immunity 2016, 45: 1219-1231. PMID: 27913094, PMCID: PMC5538583, DOI: 10.1016/j.immuni.2016.11.004.Peer-Reviewed Original ResearchConceptsCommon lymphoid progenitorsHematopoietic stem cellsMesenchymal progenitorsProgenitor differentiationHSC nicheCell lineage decisionsBone marrow nicheHSC maintenanceLineage decisionsDifferentiation signalsCytokines SCFEndothelial cellsSeparate nichesLymphoid progenitorsMultilineage differentiationMarrow nicheNicheChemokine receptor CXCR4Conditional deletionIL-7 receptorStem cellsProgenitorsDifferentiationIL-7Deletion