2020
The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights
Sasaki CT, Doukas SG, Costa J, Vageli DP. The Progressive Mutagenic Effects of Acidic Bile Refluxate in Hypopharyngeal Squamous Cell Carcinogenesis: New Insights. Cancers 2020, 12: 1064. PMID: 32344873, PMCID: PMC7281001, DOI: 10.3390/cancers12051064.Peer-Reviewed Original ResearchAcidic bileUpper aerodigestive tractAdditional risk factorsBiomarkers of progressionSquamous cell carcinogenesisNF-κB activationNeck malignanciesAerodigestive tractInvasive cancerHistopathological changesRisk factorsHypopharyngeal mucosaEarly neoplasiaMalignant lesionsP53 expressionTranslational studiesVivo modelCell carcinogenesisBileExperimental modelEarly detectionCancerNovel evidenceMutagenic effectsFirst study
1998
The Molecular Biology of Breast Cancer: Accelerating Clinical Applications
Dillon D, Howe C, Bosari S, Costa J. The Molecular Biology of Breast Cancer: Accelerating Clinical Applications. Critical Reviews™ In Oncogenesis 1998, 9: 125-140. PMID: 9973246, DOI: 10.1615/critrevoncog.v9.i2.30.Peer-Reviewed Original ResearchConceptsBreast cancerClinical applicationPreclinical disease modelsRegional oncology networkMolecular eventsOncology NetworkPractice guidelinesBRCA-1BRCA-2CancerGrowth factorTranslational researchDisease modelsPathogenesisCell deathBasic scienceCell cycle controlMetastasisClinicTherapyCycle controlMolecular biologyAbnormalitiesDiagnosis
1992
Stability of K-ras mutations throughout the natural history of human colorectal cancer
Losi L, Benhattar J, Costa J. Stability of K-ras mutations throughout the natural history of human colorectal cancer. European Journal Of Cancer 1992, 28: 1115-1120. PMID: 1627381, DOI: 10.1016/0959-8049(92)90468-h.Peer-Reviewed Original ResearchConceptsK-ras mutationsPrimary tumorRas mutationsNatural historyColorectal cancerTumor markersStable tumor markerHuman colorectal cancerDistant recurrenceRecurrent cancerRecurrent tumorsPolymerase chain reactionColorectal carcinomaCodon 12TumorsArchival tissueCancerChain reactionAllele-specific amplificationPatientsRecurrenceMarkersMutationsCarcinomaDisease
1987
Gastric Dysplasia
Saraga E, Gardiol D, Costa J. Gastric Dysplasia. The American Journal Of Surgical Pathology 1987, 11: 788-796. PMID: 3661823, DOI: 10.1097/00000478-198710000-00006.Peer-Reviewed Original Research
1981
Risk of subsequent contralateral breast carcinoma in a population of patients with in‐situ breast carcinoma
Webber B, Heise H, Neifeld J, Costa J. Risk of subsequent contralateral breast carcinoma in a population of patients with in‐situ breast carcinoma. Cancer 1981, 47: 2928-2932. PMID: 6266644, DOI: 10.1002/1097-0142(19810615)47:12<2928::aid-cncr2820471232>3.0.co;2-5.Peer-Reviewed Original ResearchConceptsBreast carcinomaContralateral carcinomaSubsequent cancerContralateral breast carcinomaMajority of patientsPopulation of patientsSecond breast cancerNoninvasive breast carcinomaSitu breast carcinomaContralateral tumorsOverall survivalContralateral breastHistological typeSurvival figuresLobular carcinomaOpposite breastBreast cancerSitu carcinomaCarcinomaS. womenCancerPatientsBreastWomenMastectomy