2014
Genetic alterations in chondrosarcomas – keys to targeted therapies?
Samuel AM, Costa J, Lindskog DM. Genetic alterations in chondrosarcomas – keys to targeted therapies? Cellular Oncology 2014, 37: 95-105. PMID: 24458248, DOI: 10.1007/s13402-014-0166-8.Peer-Reviewed Original ResearchConceptsBenign cartilaginous lesionsCartilaginous lesionsMalignant transformationIhh/PTHrPTwo-hit scenarioPrimary bone tumorsGenetic alterationsDruggable molecular targetsKey genetic alterationsHuman tumor typesResultsCurrent dataBone tumorsMalignant tumorsSarcoma typesMalignant chondrosarcomasKey molecular changesNormal cell cycle controlTumor typesMalignant cellsChondrosarcoma developmentLesionsMolecular targetsTumorsEarly-stage eventsDifferentiation of chondrocytes
1988
Histological diagnosis and grading of soft‐tissue sarcomas
Leyvraz S, Costa J. Histological diagnosis and grading of soft‐tissue sarcomas. Journal Of Surgical Oncology 1988, 4: 3-6. PMID: 3353621, DOI: 10.1002/ssu.2980040103.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasMalignant lesionsGrade 2Management of patientsHigh-grade lesionsLow-grade lesionsHistopathological differential diagnosisGrade 2 lesionsSoft tissue tumorsBasis of hematoxylinEosin-stained sectionsNational Cancer InstituteConventional special stainsLesions recurLocal recurrenceInitial diagnosisHistological diagnosisHistological typingHistological featuresDifferential diagnosisBenign tumorsBiological aggressivenessGrade 3Malignant tumorsCancer Institute