2019
Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications
Sasaki CT, Doukas SG, Costa J, Vageli DP. Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications. Cancer 2019, 125: 3554-3565. PMID: 31310330, DOI: 10.1002/cncr.32369.Peer-Reviewed Original ResearchConceptsHuman hypopharyngeal squamous cell carcinomaAdjacent normal tissuesIL-6Reflux diseaseHypopharyngeal squamous cell carcinomaMiR-375Respective adjacent normal tissuesMiR-21Pilot studyEsophageal reflux diseaseIndependent risk factorNew clinical evidenceSquamous cell carcinomaOncomiR miR-21NF-κB activationMiR-21/miRTumor suppressor miR-375Quantitative polymerase chain reactionMessenger RNABiliary refluxHypopharyngeal carcinogenesisControl patientsLaryngopharyngeal refluxClinical evidenceHypopharyngeal carcinoma
1991
Squamous Cell Carcinoma of the Lung in a Nonsmoking, Nonirradiated Patient with Juvenile Laryngotracheal Papillomatosis
Guillou L, Sahli R, Chaubert P, Monnier P, Cuttat J, Costa J. Squamous Cell Carcinoma of the Lung in a Nonsmoking, Nonirradiated Patient with Juvenile Laryngotracheal Papillomatosis. The American Journal Of Surgical Pathology 1991, 15: 891-898. PMID: 1659237, DOI: 10.1097/00000478-199109000-00010.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaMalignant transformationLaryngotracheal papillomatosisJuvenile papillomatosisCell carcinomaPrevious radiation therapySquamous cell papillomasHost immune responseSpontaneous malignant transformationPeribronchial lymphPulmonary infectionSmoking historyCell papillomasImmune responsePostmortem examinationChest wallRadiation therapyViral infectionPapillomatosisCarcinomaPatientsLungInfectionMolecular studiesLymph