2024
CBLs downregulation foretells T cell ubiquitination leading to autoimmunity
Vidyarthi A, Craft J. CBLs downregulation foretells T cell ubiquitination leading to autoimmunity. Cell Chemical Biology 2024, 31: 1239-1241. PMID: 39029453, DOI: 10.1016/j.chembiol.2024.06.010.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAutoimmunityDown-RegulationHumansProto-Oncogene Proteins c-cblT-LymphocytesUbiquitination
2010
In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development
Poholek AC, Hansen K, Hernandez SG, Eto D, Chandele A, Weinstein JS, Dong X, Odegard JM, Kaech SM, Dent AL, Crotty S, Craft J. In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development. The Journal Of Immunology 2010, 185: 313-326. PMID: 20519643, PMCID: PMC2891136, DOI: 10.4049/jimmunol.0904023.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CommunicationCell DifferentiationCricetinaeDNA-Binding ProteinsDown-RegulationFemaleImmunophenotypingLymphocyte CooperationMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutMice, TransgenicProto-Oncogene Proteins c-bcl-6SpleenT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerUp-RegulationConceptsPD-1 upregulationIL-21IL-6B cellsFollicular helper T cellsFollicular helper cell developmentDeath receptor-1Helper T cellsCytokines IL-6B cell interactionsB cell maturationTranscriptional repressor BCL6Vivo regulationCell developmentP-selectin glycoprotein ligand-1New surface markersT cellsGerminal centersInitial upregulationReceptor 1CXCR5BCL6 upregulationCell maturationSurface markersBCL6 expression
2002
IL-10 Regulates Murine Lupus
Yin Z, Bahtiyar G, Zhang N, Liu L, Zhu P, Robert ME, McNiff J, Madaio MP, Craft J. IL-10 Regulates Murine Lupus. The Journal Of Immunology 2002, 169: 2148-2155. PMID: 12165544, DOI: 10.4049/jimmunol.169.4.2148.Peer-Reviewed Original ResearchConceptsIL-10Murine lupusHuman systemic lupus erythematosusAnti-dsDNA autoantibody productionSeverity of lupusTh1 cytokine responseAnti-dsDNA autoantibodiesSystemic lupus erythematosusIFN-gamma productionIL-10 locusMRL/MpJPotential therapeutic benefitLupus syndromeSevere glomerulonephritisSevere lupusLupus modelsLupus erythematosusRIL-10Autoantibody productionCytokine responsesHuman lupusSerum concentrationsProtective effectSkin lesionsLittermate controls
2000
Dominance of IL-12 Over IL-4 in γδ T Cell Differentiation Leads to Default Production of IFN-γ: Failure to Down-Regulate IL-12 Receptor β2-Chain Expression
Yin Z, Zhang D, Welte T, Bahtiyar G, Jung S, Liu L, Fu X, Ray A, Craft J. Dominance of IL-12 Over IL-4 in γδ T Cell Differentiation Leads to Default Production of IFN-γ: Failure to Down-Regulate IL-12 Receptor β2-Chain Expression. The Journal Of Immunology 2000, 164: 3056-3064. PMID: 10706694, DOI: 10.4049/jimmunol.164.6.3056.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCells, CulturedCytokinesDNA-Binding ProteinsDown-RegulationGATA3 Transcription FactorInterferon-gammaInterleukin-12Interleukin-4Lymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred C57BLReceptors, Antigen, T-Cell, gamma-deltaReceptors, InterleukinReceptors, Interleukin-12Signal TransductionSTAT3 Transcription FactorSTAT4 Transcription FactorTh1 CellsTh2 CellsT-Lymphocyte SubsetsTrans-ActivatorsConceptsGamma delta T cellsDelta T cellsT cellsIFN-gammaIL-12IL-4Murine gamma delta T cellsSplenic gamma delta T cellsAlpha beta T cellsIFN-gamma-producing cellsΓδ T-cell differentiationIL-4-secreting cellsBeta T cellsTh2-like cytokinesIL-12 receptorTranscription factor GATA-3T cell differentiationTumor immunityTh1 cellsTh2 cellsSuch cytokinesFinding independentReceptor betaGATA-3Intracellular pathogens
1998
Central T cell tolerance in lupus-prone mice: influence of autoimmune background and the lpr mutation.
Fatenejad S, Peng SL, Disorbo O, Craft J. Central T cell tolerance in lupus-prone mice: influence of autoimmune background and the lpr mutation. The Journal Of Immunology 1998, 161: 6427-32. PMID: 9834135, DOI: 10.4049/jimmunol.161.11.6427.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisAutoimmune DiseasesCell LineClonal DeletionColumbidaeCytochrome c GroupDown-RegulationFas ReceptorGene Rearrangement, alpha-Chain T-Cell Antigen ReceptorImmune ToleranceLupus NephritisLymphocyte ActivationMiceMice, Inbred C57BLMice, Inbred MRL lprMice, TransgenicMolecular Sequence DataMutationPeptidesReceptors, Antigen, T-Cell, alpha-betaT-Lymphocyte SubsetsThymus GlandConceptsMRL/MpJ miceLupus-prone miceT cell toleranceCentral T cell toleranceT cellsLpr mutationCell toleranceSystemic autoimmune diseaseT cell autoreactivityAutoreactive T cellsB cell helpIntrathymic negative selectionMHC class IIMRL/MpJPeripheral control mechanismsAutoimmune backgroundThymic deletionIntrathymic deletionAutoimmune diseasesNonautoimmune miceCell helpTCR transgeneNonautoimmune strainsPeptide AgImmature CD4