2017
CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation
Kuwahara G, Hashimoto T, Tsuneki M, Yamamoto K, Assi R, Foster TR, Hanisch JJ, Bai H, Hu H, Protack CD, Hall MR, Schardt JS, Jay SM, Madri JA, Kodama S, Dardik A. CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation. Arteriosclerosis Thrombosis And Vascular Biology 2017, 37: 1147-1156. PMID: 28450292, PMCID: PMC5467640, DOI: 10.1161/atvbaha.117.309385.Peer-Reviewed Original ResearchConceptsExtracellular matrix depositionKnockout miceExtracellular matrix componentsExtracellular matrix productionMatrix depositionAdhesion molecule-1 expressionM2 macrophagesProtein 1Matrix productionCell adhesion molecule-1 expressionMolecule-1 expressionProtein expressionMatrix componentsCD44 knockout miceProtein-1 expressionMajor receptorCD44 activityMaturationVascular cell adhesion molecule-1 expressionAdhesion moleculesExpressionCD44 mRNAChemoattractant protein-1 expressionWild-type C57BL/6JArteriovenous fistula
2014
Temporal Regulation of venous Extracellular Matrix Components during Arteriovenous Fistula Maturation
Hall MR, Yamamoto K, Protack CD, Tsuneki M, Kuwahara G, Assi R, Brownson KE, Bai H, Madri JA, Dardik A. Temporal Regulation of venous Extracellular Matrix Components during Arteriovenous Fistula Maturation. The Journal Of Vascular Access 2014, 16: 93-106. PMID: 25262757, PMCID: PMC4405006, DOI: 10.5301/jva.5000290.Peer-Reviewed Original ResearchConceptsExtracellular matrix componentsTemporal regulationECM componentsStructural proteinsMatrix componentsGene microarray analysisMatrix metalloproteinasesRegulatory proteinsMicroarray analysisNon-collagenous proteinsDistinct temporal patternsECM degradationTemporal patternsProteinProtein expressionElastin expressionExpressionMaturationOsteopontin expressionProtease inhibitorsHuman AVF maturationRegulationTissue inhibitorDays of maturationMetalloproteinase-1
1998
Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis
Ilan N, Mahooti S, Madri J. Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis. Journal Of Cell Science 1998, 111: 3621-3631. PMID: 9819353, DOI: 10.1242/jcs.111.24.3621.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisCalcium-Calmodulin-Dependent Protein KinasesCapillariesCell Culture TechniquesCell LineCell SurvivalCollagenEndothelial Growth FactorsEndothelium, VascularExtracellular MatrixHumansLymphokinesNeovascularization, PhysiologicPhosphatidylinositol 3-KinasesPhosphorylationProtein Kinase CProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktSignal TransductionTetradecanoylphorbol AcetateVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsHuman umbilical vein endothelial cellsAkt/PKB pathwayTube formationDistinct signal transduction pathwaysAkt/PKBSignal transduction pathwaysDifferent ECM proteinsCollagen gelsExtracellular matrix componentsPeptide growth factorsPKB pathwayProtein kinaseTransduction pathwaysMAP kinaseUmbilical vein endothelial cellsECM proteinsVein endothelial cellsNew blood vesselsPre-existing onesKinaseMajor groupsVivo angiogenesisRapid inductionMatrix componentsSurvival phase
1997
An in vitro three-dimensional coculture model of cerebral microvascular angiogenesis and differentiation
Ment L, Stewart W, Scaramuzzino D, Madri J. An in vitro three-dimensional coculture model of cerebral microvascular angiogenesis and differentiation. In Vitro Cellular & Developmental Biology - Animal 1997, 33: 684-691. PMID: 9358284, DOI: 10.1007/s11626-997-0126-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAstrocytesBrainCell DifferentiationCoculture TechniquesDogsEndothelium, VascularEnzyme ActivationFibronectinsImmunohistochemistryLamininMicrocirculationMicroscopy, ConfocalMicroscopy, FluorescenceModels, BiologicalNeovascularization, PhysiologicRatsRNA, MessengerUrokinase-Type Plasminogen ActivatorConceptsAstrocyte coculturesThree-dimensional cocultureBrain microvascular endothelial cellsNewborn beagle pupsPostnatal day 1Microvascular endothelial cellsNeonatal rat forebrainCell typesPlasminogen activator activityPreterm birthMicrovascular responsesBeagle pupsThree-dimensional coculture modelDay 1Rat forebrainGlial processesEndothelial proliferationMicrovascular angiogenesisEndothelial cellsCoculture modelPlasminogen zymographyOnly low levelsExtracellular matrix componentsTube formationCoculture
1996
Role of plasminogen activator inhibitor in the reciprocal regulation of bovine aortic endothelial and smooth muscle cell migration by TGF-beta 1.
Petzelbauer E, Springhorn J, Tucker A, Madri J. Role of plasminogen activator inhibitor in the reciprocal regulation of bovine aortic endothelial and smooth muscle cell migration by TGF-beta 1. American Journal Of Pathology 1996, 149: 923-31. PMID: 8780396, PMCID: PMC1865168.Peer-Reviewed Original ResearchConceptsVascular cell typesCell typesSmooth muscle cellsPlasminogen activator inhibitorMuscle cellsAnti-catalytic antibodyActivator inhibitorExtracellular matrix componentsMigratory rateVascular smooth muscle cellsEndothelial cellsSmooth muscle cell migrationUrokinase plasminogen activatorMigratory behaviorReciprocal regulationMuscle cell migrationStable transfectantsCell migrationExtracellular matrixIntegrin synthesisMatrix componentsMigratory responseProteolytic phenotypeProteolytic activityGrowth factorLaminin promotes differentiation of NB4 promyelocytic leukemia cells with all-trans retinoic acid.
Becker P, Li Z, Potselueva T, Madri J, Newburger P, Berliner N. Laminin promotes differentiation of NB4 promyelocytic leukemia cells with all-trans retinoic acid. Blood 1996, 88: 261-7. PMID: 8704182, DOI: 10.1182/blood.v88.1.261.bloodjournal881261.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDBase SequenceCalciumCell Culture TechniquesCell DifferentiationCell DivisionCollagenDrug SynergismFibronectinsGene Expression Regulation, LeukemicHumansIntegrin alpha6Integrin beta1IonomycinIonophoresLamininLeukemia, Promyelocytic, AcuteMolecular Sequence DataNeoplasm ProteinsNeoplastic Stem CellsOxidation-ReductionPolymerase Chain ReactionReceptors, LamininTretinoinTumor Cells, CulturedConceptsAlpha 6 integrinTrans retinoic acidNB4 promyelocytic leukemia cellsPromyelocytic leukemia cellsMorphologic maturationLeukemia cellsRetinoic acidReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionSecondary granule proteinsPresence of ionomycinPromyelocytic leukemia cell lineHistologic appearanceHours of exposureLeukemia cell linesMinimal maturationFlow cytometryHigh-level surface expressionDifferentiation agentsCollagen type INB4 cellsLaminin receptorATRAExtracellular matrix componentsCell proliferationLaminin promotes differentiation of NB4 promyelocytic leukemia cells with all-trans retinoic acid
Becker P, Li Z, Potselueva T, Madri J, Newburger P, Berliner N. Laminin promotes differentiation of NB4 promyelocytic leukemia cells with all-trans retinoic acid. Blood 1996, 88: 261-267. DOI: 10.1182/blood.v88.1.261.261.Peer-Reviewed Original ResearchAlpha 6 integrinTrans retinoic acidNB4 promyelocytic leukemia cellsPromyelocytic leukemia cellsMorphologic maturationLeukemia cellsRetinoic acidReverse transcription-polymerase chain reactionTranscription-polymerase chain reactionSecondary granule proteinsPresence of ionomycinPromyelocytic leukemia cell lineHistologic appearanceHours of exposureLeukemia cell linesMinimal maturationFlow cytometryHigh-level surface expressionDifferentiation agentsCollagen type INB4 cellsLaminin receptorATRAExtracellular matrix componentsCell proliferation
1993
Fibronectin expression correlates with U937 cell adhesion to migrating bovine aortic endothelial cells in vitro.
Hauser I, Setter E, Bell L, Madri J. Fibronectin expression correlates with U937 cell adhesion to migrating bovine aortic endothelial cells in vitro. American Journal Of Pathology 1993, 143: 173-80. PMID: 7686342, PMCID: PMC1886955.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaCattleCell AdhesionCell MovementCells, CulturedDrug ResistanceEndothelium, VascularFibronectinsFluorescent Antibody TechniqueHumansIntegrinsLeukemia, Promyelocytic, AcuteNeomycinProto-Oncogene MasProto-Oncogene Proteins pp60(c-src)Transforming Growth Factor betaTumor Cells, CulturedConceptsCell adhesionU937 cell adhesionEndothelial cell populationSRC proto-oncogeneEndothelial cellsCell populationsExtracellular matrix componentsEndothelial cell migrationBovine aortic endothelial cellsExtracellular matrix synthesisDenudation injuryFibronectin depositionCell migrationProto-oncogeneVascular endothelial cellsU937 cellsAortic endothelial cellsAmount of fibronectinMatrix componentsMigratory responseEndothelial cell monolayersMatrix synthesisCellsCell monolayersAdhesion
1992
Matrix composition, organization and soluble factors: Modulators of microvascular cell differentiation in vitro
Madri J, Marx M. Matrix composition, organization and soluble factors: Modulators of microvascular cell differentiation in vitro. Kidney International 1992, 41: 560-565. PMID: 1573829, DOI: 10.1038/ki.1992.82.Peer-Reviewed Original ResearchConceptsCell typesStructure/functionMajor cell typesExtracellular matrix componentsVascular cell behaviorVascular smooth muscle cellsEndothelial cellsCell differentiationSoluble factorsCell behaviorExtracellular matrixNeighboring cellsMetabolic functionsDirect interactionSmooth muscle cellsMatrix componentsCell populationsMorphological organizationMuscle cellsMicrovascular endothelial cellsCulture modelCellsMesangial cell populationOrgan culture modelCell isolation
1991
Beagle pup germinal matrix maturation studies.
Ment L, Stewart W, Ardito T, Madri J. Beagle pup germinal matrix maturation studies. Stroke 1991, 22: 390-395. PMID: 2003309, DOI: 10.1161/01.str.22.3.390.Peer-Reviewed Original ResearchConceptsAlpha-smooth muscle actinIntraventricular hemorrhageDay 1Muscle actinRisk periodGlial fibrillary acidic proteinGerminal matrix vasculatureNewborn beagle pupsPostnatal day 1Postnatal day 4Postnatal day 10Fibrillary acidic proteinGerminal matrix vesselsGerminal matrix tissuePreterm infantsImmunohistochemical studyPerinatal maturationPostnatal dayBeagle pupsVessel densityHemorrhageExtracellular matrix componentsDay 4Day 10Basement membrane proteins
1989
Modulation of actin mRNAs in cultured vascular cells by matrix components and TGF-β1
Kocher O, Madri J. Modulation of actin mRNAs in cultured vascular cells by matrix components and TGF-β1. In Vitro Cellular & Developmental Biology 1989, 25: 424-434. PMID: 2659578, DOI: 10.1007/bf02624627.Peer-Reviewed Original ResearchConceptsTwo-dimensional cultureActin mRNAEndothelial cell populationSmooth muscle cellsIndividual extracellular matrix proteinsSmooth muscle cell differentiationCell typesRat capillary endothelial cellsMuscle cell differentiationActin mRNA expressionThree-dimensional type ISkeletal muscle cellsMatrix componentsExtracellular matrix proteinsCell populationsCytoplasmic actin mRNAsMuscle actin mRNAEndothelial cellsMuscle cellsSmooth muscle cell markersExtracellular matrix componentsCultured vascular cellsΑ-SM actinBovine aortic endothelial cellsMuscle cell markers
1988
Matrix-driven cell size change modulates aortic endothelial cell proliferation and sheet migration.
Madri J, Pratt B, Yannariello-Brown J. Matrix-driven cell size change modulates aortic endothelial cell proliferation and sheet migration. American Journal Of Pathology 1988, 132: 18-27. PMID: 3394798, PMCID: PMC1880627.Peer-Reviewed Original ResearchConceptsSheet migrationBovine aortic endothelial cellsCellular functionsCell size changesEndothelial cell proliferationCell proliferationMatrix componentsExtracellular matrix component lamininExtracellular matrix componentsEndothelial cellsNuclear sizeExtracellular matrixAortic endothelial cellsModel systemSize changesCurrent hypothesesProliferationPhysiologic homeostasisCellsType IV collagenComplex fashionDistinct patternsCell attachmentMigrationRate of attachmentAngiogenesis
Madri J, Sankar S, Romanic A. Angiogenesis. 1988, 355-371. DOI: 10.1007/978-1-4899-0185-9_11.Peer-Reviewed Original Research
1987
Aortic endothelial cell proteoheparan sulfate. II. Modulation by extracellular matrix.
Keller R, Pratt B, Furthmayr H, Madri J. Aortic endothelial cell proteoheparan sulfate. II. Modulation by extracellular matrix. American Journal Of Pathology 1987, 128: 299-306. PMID: 2956886, PMCID: PMC1899612.Peer-Reviewed Original ResearchConceptsExtracellular matrixPlasma membraneHS IProteoheparan sulfate speciesSulfate biosynthesisEndothelial cellsHS IIIHS IICell polarityMajor cell typesExtracellular matrix componentsPolarized secretionBovine aortic endothelial cellsOrgan cultureTissue culture plasticSubcellular matrixBiosynthetic phenotypeMedium of cellsDifferentiated phenotypeCell typesMatrix moleculesVascular endothelial cellsAortic endothelial cellsProteoheparan sulfateSpecies