2020
Primary melanotic tumors of the nervous system: a consecutive case series
Grosshans H, Huttner A, Piepmeier J, Kaulen L, Fulbright R, Baehring J, Karschnia P. Primary melanotic tumors of the nervous system: a consecutive case series. European Journal Of Neurology 2020, 27: 2303-2307. PMID: 32654331, DOI: 10.1111/ene.14437.Peer-Reviewed Original ResearchMeSH KeywordsHumansImmunohistochemistryMagnetic Resonance ImagingMelaninsNervous System NeoplasmsRetrospective StudiesConceptsPrimary melanotic tumorsNervous systemRelapsed diseaseClinical presentationMelanotic lesionsFavorable outcomeRadiation therapyPre-contrast T1-weighted imagingRelative incidenceMelanotic tumorsHomogenous contrast enhancementYale Cancer CenterAggressive surgical treatmentConsecutive case seriesPsammomatous melanotic schwannomaNervous system tumorsT1-weighted imagingT2-weighted imagingTumor mass effectMagnetic resonance imagingMelanin-containing cellsS100 positivitySurgical resectionSurgical treatmentTumor Registry
2014
Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance
Strohbehn G, Coman D, Han L, Ragheb RR, Fahmy TM, Huttner AJ, Hyder F, Piepmeier JM, Saltzman WM, Zhou J. Imaging the delivery of brain-penetrating PLGA nanoparticles in the brain using magnetic resonance. Journal Of Neuro-Oncology 2014, 121: 441-449. PMID: 25403507, PMCID: PMC4323763, DOI: 10.1007/s11060-014-1658-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBrain NeoplasmsConvectionDrug Delivery SystemsFerric CompoundsGlioblastomaHumansImage Processing, Computer-AssistedLactic AcidMagnetic Resonance ImagingNanoparticlesNeuroimagingPolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerRatsRats, Sprague-DawleyConceptsBrain-penetrating nanoparticlesSuperparamagnetic iron oxideEfficient deliveryDrug-loaded nanoparticlesDistribution of nanoparticlesTransverse relaxivityPLGA nanoparticlesNanoparticlesConvection-enhanced deliveryDelivery platformFuture clinical applicationsUniversal tumor recurrenceClinical translationSignal attenuationDetection modalitiesIron oxideSame morphologyParticle distributionDeliveryGroundbreaking approachClinical applicationRelevant volumesRelaxivityTreatment of GBMOxide
2010
Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma†
Kunwar S, Chang S, Westphal M, Vogelbaum M, Sampson J, Barnett G, Shaffrey M, Ram Z, Piepmeier J, Prados M, Croteau D, Pedain C, Leland P, Husain SR, Joshi BH, Puri RK, Group F. Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma†. Neuro-Oncology 2010, 12: 871-881. PMID: 20511192, PMCID: PMC2940677, DOI: 10.1093/neuonc/nop054.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntineoplastic AgentsBrain NeoplasmsCarmustineCatheters, IndwellingConvectionDecanoic AcidsDrug Administration RoutesExotoxinsFemaleGlioblastomaHumansInterleukin-13Kaplan-Meier EstimateMagnetic Resonance ImagingMaleMiddle AgedNeoplasm Recurrence, LocalPolyestersRecombinant Fusion ProteinsYoung AdultConceptsConvection-enhanced deliveryCintredekin besudotoxGliadel wafersMedian survivalTumor resectionGlioblastoma multiformeEfficacy-evaluable populationAdverse event profileHealth-related qualityPhase III evaluationTime of randomizationEvaluable populationTertiary endpointsPrimary endpointAdult patientsBaseline characteristicsFirst recurrenceOverall survivalPulmonary embolismActive comparatorTreatment armsIL13-PE38QQRIntraparenchymal catheterSurvival differencesGBM patients
2009
Anaplastic oligoastrocytoma in Turcot syndrome
Baehring J, Hui P, Piepmeier J, Bannykh SI. Anaplastic oligoastrocytoma in Turcot syndrome. Journal Of Neuro-Oncology 2009, 95: 293-298. PMID: 19495563, DOI: 10.1007/s11060-009-9928-y.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdenosine TriphosphatasesAgedAstrocytomaColorectal Neoplasms, Hereditary NonpolyposisDNA Repair EnzymesDNA-Binding ProteinsDNA, NeoplasmFemaleHumansImmunoenzyme TechniquesMagnetic Resonance ImagingMismatch Repair Endonuclease PMS2MutL Protein Homolog 1MutS Homolog 2 ProteinNuclear ProteinsPedigreePolymerase Chain ReactionConceptsHereditary non-polyposis colorectal cancerTurcot syndromeAnaplastic oligoastrocytomaNon-polyposis colorectal cancerYear old womanHandful of casesColorectal cancerLarge bowelDNA mismatch repair systemOlder womenBrain tumorsTumor DNABody sitesFamilial clusteringGermline mutationsRare variantsSyndromeOligoastrocytomasCancerMismatch repair systemChance occurrenceDetailed molecular dataBowelPathogenesisTumorsPrimary, non-exophytic, optic nerve germ cell tumors
DiLuna ML, Two AM, Levy GH, Patel T, Huttner AJ, Duncan CC, Piepmeier JM. Primary, non-exophytic, optic nerve germ cell tumors. Journal Of Neuro-Oncology 2009, 95: 437-443. PMID: 19554263, DOI: 10.1007/s11060-009-9941-1.Peer-Reviewed Original ResearchMeSH KeywordsBiopsyChildCraniotomyDiabetes InsipidusHumansMagnetic Resonance ImagingMaleNeoplasms, Germ Cell and EmbryonalOptic ChiasmOptic Nerve NeoplasmsYoung AdultConceptsGerm cell tumorsOptic chiasmatic gliomasMalignant mixed germ cell tumorMixed germ cell tumorOptic chiasmCell tumorsOptic chiasm tumorAdrenal axis dysfunctionSub-frontal approachChiasm gliomaChiasmatic gliomasAxis dysfunctionBiopsy confirmationProgressive symptomsVisual lossCase seriesFirst patientTreatment regimensPterional craniotomyDiabetes insipidusTissue diagnosisTissue biopsiesTumorsPatientsChiasm
2006
Chondrosarcoma of the Skull Base
Baehring JM, Piepmeier J, Duncan C, Liebsch N, Ogle E, Kim J. Chondrosarcoma of the Skull Base. Journal Of Neuro-Oncology 2006, 76: 49-49. PMID: 16402277, DOI: 10.1007/s11060-005-5981-3.Peer-Reviewed Original ResearchAdolescentChondrosarcomaHeadacheHumansMagnetic Resonance ImagingMaleNystagmus, PathologicSkull Base Neoplasms
2004
Tumors of the posterior third ventricle and pineal region: ependymoma and germinoma
Baehring J, Vives K, Duncan C, Piepmeier J, Bannykyh S. Tumors of the posterior third ventricle and pineal region: ependymoma and germinoma. Journal Of Neuro-Oncology 2004, 70: 273-274. PMID: 15674486, DOI: 10.1007/s11060-004-5395-7.Peer-Reviewed Original ResearchAdolescentAdultBrain NeoplasmsEpendymomaFemaleGerminomaHumansMagnetic Resonance ImagingMalePinealomaRadiographyThird VentricleMelanocytoma
Bannykh S, Piepmeier J, Baehring J. Melanocytoma. Journal Of Neuro-Oncology 2004, 70: 35-35. PMID: 15527105, DOI: 10.1023/b:neon.0000040895.76760.69.Peer-Reviewed Original ResearchSurgical Resection for Patients with Benign Primary Brain Tumors and Low Grade Gliomas
Piepmeier J, Baehring JM. Surgical Resection for Patients with Benign Primary Brain Tumors and Low Grade Gliomas. Journal Of Neuro-Oncology 2004, 69: 55-65. PMID: 15527080, DOI: 10.1023/b:neon.0000041871.46785.53.Peer-Reviewed Original ResearchMeSH KeywordsBrain NeoplasmsGliomaHumansMagnetic Resonance ImagingNeurosurgical ProceduresTreatment OutcomeConceptsPrimary brain tumorsBrain tumorsNeuroepithelial tumorsBenign primary brain tumorsMajority of patientsAdverse treatment effectsBenefits of therapyLow-grade tumorsLow-grade gliomasSurgical resectionInitial diagnosisMalignant degenerationPrimary neoplasmsSurgical managementSeizure focusBrain parenchymaChordoid gliomaNeurosurgical interventionThird ventricleChoroid plexusGrade gliomasTumorsUnknown originHeterogeneous groupCell poolNon-enhancing de novo glioblastoma: report of two cases
Cohen-Gadol AA, DiLuna ML, Bannykh SI, Piepmeier JM, Spencer DD. Non-enhancing de novo glioblastoma: report of two cases. Neurosurgical Review 2004, 27: 281-285. PMID: 15449198, DOI: 10.1007/s10143-004-0346-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBrain NeoplasmsGlioblastomaHumansMagnetic Resonance ImagingMaleRadiographyTumor Suppressor Protein p53ConceptsRing-enhancing lesionsLow-grade lesionsSecond patientMalignant gliomasRight medial temporal lobe lesionInitial MRI evaluationTraditional imaging findingsDe novo lesionsNew-onset seizuresMedial temporal lobe lesionsT2 signal changeRight precentral gyrusTemporal lobe lesionsMedial temporal lesionsRight frontal lesionDe novo glioblastomaEarly MRINovo lesionsNeurological examinationSubsequent resectionImaging findingsFirst patientMRI evaluationTumor suggestiveTemporal lesions
2001
Patterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system.
Carpentier A, Constable R, Schlosser M, de Lotbinière A, Piepmeier J, Spencer D, Awad I. Patterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system. Journal Of Neurosurgery 2001, 94: 946-54. PMID: 11409524, DOI: 10.3171/jns.2001.94.6.0946.Peer-Reviewed Original ResearchConceptsFMR imaging activationSurgical interventionRolandic regionMotor cortex plasticityMotor task paradigmFunctional magnetic resonance imagingMotor skillsMagnetic resonance imagingSevere motor impairmentFunctional magnetic resonanceFunctional recoveryLesion sideCortical abnormalitiesMotor cortexControl volunteersCortical malformationsStructural lesionsContralateral hemisphereArteriovenous malformationsBrain lesionsSurgical proceduresMotor impairmentPathological lesionsFunctional reorganizationAuthors' institution
1988
Malignant Glioma of the Optic Chiasm Eight Years After Radiotherapy for Prolactinoma
Hufnagel T, Kim J, Lesser R, Miller J, Abrahams J, Piepmeier J, Manuelidis E. Malignant Glioma of the Optic Chiasm Eight Years After Radiotherapy for Prolactinoma. JAMA Ophthalmology 1988, 106: 1701-1705. PMID: 3196211, DOI: 10.1001/archopht.1988.01060140873031.Peer-Reviewed Original Research