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Josephine Hoh, PhD

Associate Professor of Epidemiology (Chronic Diseases) and of Ophthalmology and Visual Science
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Contact Info

Yale School of Public Health

PO Box 208034, 60 College Street

New Haven, CT 06520-8034

United States

About

Titles

Associate Professor of Epidemiology (Chronic Diseases) and of Ophthalmology and Visual Science

Biography

Josephine Hoh, associate professor in chronic disease epidemiology and of ophthalmology and visual science, is currently involved in interdisciplinary research to elucidate disease pathophysiology, including how the genetic factors can actually lead individuals who carrying the risk variants to be ill at one point in life, what the environmental exposures are, and how they can influence an individual’s chance of contracting the disease.

Dr. Hoh was trained in mathematics in Taiwan and theoretical statistics and probability under the supervision of Professor Zhiliang Ying and the late Professor Herbert Robbins at Rutgers University.

As a research assistant professor at Rockefeller University she worked with Jurg Ott on linkage analysis for genetic factors of human disease and developed her expertise in biology. Two of the computational methods and tools they developed, SUMSTAT and p53MH, continue to be widely used. SUMSTAT can efficiently and effectively identify disease associated genetic variants, while p53MH and its extension can identify the DNA response elements of a tumor suppressor p53 as well as other transcription factors.

Now an associate professor at the Yale School of Public Health, Hoh focuses on developing new approaches to discover the genetic risks for more common diseases which usually have complex influences from both genetics and environmental exposures. Collaborating with national and international groups (Drs. Emily Chew and Rick Ferris at the National Eye Institute and Dr. Calvin Pang of Hong Kong University) her work on age-related macular degeneration (AMD), the most common cause of blindness in developed world, led to the first successful application of the genome-wide association study (GWAS) approach and was published widely. By employing GWAS, the Hoh lab has also investigated other complex traits including carcinoid cancer, scleroderma, asthma, longevity, among others.

Appointments

Other Departments & Organizations

Education & Training

PhD
Rutgers University (1998)
BS
National Tsing Hua University (1989)

Research

Overview

Medical Subject Headings (MeSH)

Environmental Exposure; Environmental Health; Ophthalmology

Research at a Glance

Yale Co-Authors

Frequent collaborators of Josephine Hoh's published research.

Publications

2024

2010

2009

2007

2006

2005

2001

Get In Touch

Contacts

Academic Office Number
Lab Number
Office Fax Number
Mailing Address

Yale School of Public Health

PO Box 208034, 60 College Street

New Haven, CT 06520-8034

United States

Locations

  • 60 College Street

    Academic Office

    Ste Room 416

    New Haven, CT 06510