2024
Complement factor H in molecular regulation of angiogenesis
Li J, Wang K, Starodubtseva M, Nadyrov E, Kapron C, Hoh J, Liu J. Complement factor H in molecular regulation of angiogenesis. Medical Review 2024, 4: 452-466. PMID: 39444793, PMCID: PMC11495524, DOI: 10.1515/mr-2023-0048.Peer-Reviewed Original ResearchComplement factor HComplement factor H geneAge-related macular degenerationComplement factor H proteinFactor HComplement activation fragmentsC-reactive proteinAnti-angiogenic effectsEndothelial heparan sulfateChoroidal neovascularizationMacular degenerationRegulation of angiogenesisMolecular regulation of angiogenesisDeficient miceComplement 3aMembrane attack complexComplement 5aPro-angiogenic eventsAngiogenesis-related diseasesCFH expressionPro-angiogenic capacityAlternative pathwayTherapeutic potentialComplement systemBlood vessels
2006
A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, DeWan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K. A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration. Science 2006, 314: 992-993. PMID: 17053109, DOI: 10.1126/science.1133811.Peer-Reviewed Original ResearchMeSH KeywordsAgedAgingAllelesCase-Control StudiesChromosomes, Human, Pair 10Cohort StudiesFemaleGenetic Predisposition to DiseaseGenotypeHigh-Temperature Requirement A Serine Peptidase 1HomozygoteHumansLymphocytesMacular DegenerationMaleMiddle AgedPigment Epithelium of EyePolymorphism, Single NucleotidePromoter Regions, GeneticRetinal DrusenReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSerine EndopeptidasesWhite PeopleConceptsAge-related macular degenerationAMD patientsMacular degenerationRisk of AMDPopulation attributable riskIrreversible vision lossStrong genetic predispositionRetinal pigment epitheliumAMD pathogenesisAttributable riskVision lossElevated expression levelsCommon causeSecreted serine proteaseNormal controlsGenetic predispositionPigment epitheliumCaucasian cohortAMD casesAMD susceptibilityIncreases SusceptibilityRisk allelesHTRA1 geneSingle nucleotide polymorphismsPotential new pathways
2005
Complement Factor H Polymorphism in Age-Related Macular Degeneration
Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, Henning AK, SanGiovanni JP, Mane SM, Mayne ST, Bracken MB, Ferris FL, Ott J, Barnstable C, Hoh J. Complement Factor H Polymorphism in Age-Related Macular Degeneration. Science 2005, 308: 385-389. PMID: 15761122, PMCID: PMC1512523, DOI: 10.1126/science.1109557.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAllelesAmino Acid SubstitutionCase-Control StudiesChoroidChromosomes, Human, Pair 1Complement Factor HComplement Membrane Attack ComplexExonsFemaleGenetic MarkersGenetic Predisposition to DiseaseGenotypeHaplotypesHistidineHumansImmunity, InnateIntronsLinkage DisequilibriumMacular DegenerationMaleOligonucleotide Array Sequence AnalysisPigment Epithelium of EyePolymorphism, GeneticPolymorphism, Single NucleotideRisk FactorsSmokingConceptsAge-related macular degenerationComplement factor H (CFH) geneMacular degenerationLikelihood of AMDComplement Factor H PolymorphismRisk allelesC-reactive proteinFactor H geneAmino acids 402H polymorphismCFH geneFamily-based studyMajor causeSingle nucleotide polymorphismsCommon variantsDegenerationPolymorphismH gene