2023
Concurrent carboplatin and paclitaxel definitive radiation therapy for locally advanced head and neck cancer
Han J, Zakeri K, Raab G, Hesse J, Shamseddine A, Chen L, Yu Y, Kang J, McBride S, Riaz N, Tsai C, Gelblum D, Sherman E, Wong R, Michel L, Lee N. Concurrent carboplatin and paclitaxel definitive radiation therapy for locally advanced head and neck cancer. Head & Neck 2023, 45: 2207-2216. PMID: 37439286, PMCID: PMC10981461, DOI: 10.1002/hed.27456.Peer-Reviewed Original ResearchConceptsLocoregional recurrenceDistant metastasisOverall survivalHNSCC patientsConcurrent carboplatinDefinitive chemoradiationConsecutive HNSCC patientsDefinitive radiation therapyMedian radiation doseKaplan-Meier methodCumulative incidence functionFree survivalAdvanced headMedian ageMedian dosesNeck cancerAUC 1Radiation therapyCarboplatinPatientsChemoradiationPaclitaxelRadiation doseExcellent optionIncidence function
2021
Long-term Therapeutic and Functional Outcomes With Organ Preservation for T4 Larynx and Hypopharynx Cancers
Rybkin A, Eita A, Kang J, Fiasconaro M, Zhang Z, Zakeri K, Yu Y, Chen L, Gelblum D, Tsai C, Riaz N, McBride S, Sherman E, Dunn L, Ho A, Cohen M, Cracchiolo J, Pfister D, Wong R, Lee N. Long-term Therapeutic and Functional Outcomes With Organ Preservation for T4 Larynx and Hypopharynx Cancers. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: e365-e366. DOI: 10.1016/j.ijrobp.2021.07.1084.Peer-Reviewed Original ResearchPercutaneous endoscopic gastrostomyDisease-free survivalHypopharynx cancerLocoregional failureOverall survivalUnivariate analysisChemoradiation therapyRadiation therapySurgical candidatesDistant metastasisStage T4Functional outcomeMedian disease-free intervalAdequate supportive careOrgan preservation trialsYear OS ratesDefinitive radiation therapyDisease-free intervalKaplan-Meier methodLarynx groupSupportive careEndoscopic gastrostomyMethods PatientsNodal statusNonoperative managementAny day, split halfway: Flexibility in scheduling high‐dose cisplatin—A large retrospective review from a high‐volume cancer center
Kang JJ, Tchekmedyian V, Mohammed N, Rybkin A, Kitpanit S, Fan M, Wang H, Lobaugh SM, Zhang Z, Lee A, Chen L, Yu Y, Zakeri K, Gelblum DY, Riaz N, McBride SM, Tsai CJ, Cohen MA, Cracchiolo JR, Morris LG, Singh B, Patel S, Ganly I, Boyle JO, Wong RJ, Eng J, Zhi WI, Ng K, Ho AL, Dunn LA, Michel L, Fetten JV, Pfister DG, Lee NY, Sherman EJ. Any day, split halfway: Flexibility in scheduling high‐dose cisplatin—A large retrospective review from a high‐volume cancer center. International Journal Of Cancer 2021, 149: 139-148. PMID: 33586179, PMCID: PMC9380235, DOI: 10.1002/ijc.33518.Peer-Reviewed Original ResearchConceptsTotal cumulative doseHigh-dose cisplatinLocoregional failureOverall survivalOropharyngeal cancerDistant metastasisRegional failureHigh-volume cancer centerLocal failureAlternate dosing schedulesHuman papillomavirus (HPV) statusKarnofsky performance statusCooperative group trialsAdvanced oropharyngeal cancerLarge retrospective reviewStandard of careMultivariable regression modelsDefinitive chemoradiationInduction chemotherapyPerformance statusDosing schedulesTherapy startAdministration dayRetrospective reviewRenal toxicity
2019
Platinum‐based regimens versus cetuximab in definitive chemoradiation for human papillomavirus‐unrelated head and neck cancer
Beckham TH, Barney C, Healy E, Wolfe AR, Branstetter A, Yaney A, Riaz N, McBride SM, Tsai CJ, Kang J, Yu Y, Chen L, Sherman E, Dunn L, Pfister DG, Tan J, Rupert R, Bonomi M, Zhang Z, Lobaugh SM, Grecula JC, Mitchell DL, Wobb JL, Miller ED, Blakaj DM, Diavolitsis VM, Lee N, Bhatt AD. Platinum‐based regimens versus cetuximab in definitive chemoradiation for human papillomavirus‐unrelated head and neck cancer. International Journal Of Cancer 2019, 147: 107-115. PMID: 31609479, DOI: 10.1002/ijc.32736.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCetuximabChemoradiotherapyCisplatinFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedNeoplasm StagingPapillomaviridaePapillomavirus InfectionsRandomized Controlled Trials as TopicSquamous Cell Carcinoma of Head and NeckSurvival RateConceptsLocoregional failureOverall survivalDistant metastasisReduced hazardMultivariable analysisKaplan-MeierHuman papillomavirus-unrelated headNeck squamous cell carcinomaPlatinum-based regimensSquamous cell carcinomaSuperior locoregional controlCumulative incidence functionDefinitive chemoradiationDefinitive radiotherapyLocoregional controlAdvanced headClinical characteristicsCumulative incidenceConcurrent cetuximabPropensity matchingYear OSCell carcinomaHuman papillomavirusNeck cancerProportional hazards