2023
Concurrent carboplatin and paclitaxel definitive radiation therapy for locally advanced head and neck cancer
Han J, Zakeri K, Raab G, Hesse J, Shamseddine A, Chen L, Yu Y, Kang J, McBride S, Riaz N, Tsai C, Gelblum D, Sherman E, Wong R, Michel L, Lee N. Concurrent carboplatin and paclitaxel definitive radiation therapy for locally advanced head and neck cancer. Head & Neck 2023, 45: 2207-2216. PMID: 37439286, PMCID: PMC10981461, DOI: 10.1002/hed.27456.Peer-Reviewed Original ResearchConceptsLocoregional recurrenceDistant metastasisOverall survivalHNSCC patientsConcurrent carboplatinDefinitive chemoradiationConsecutive HNSCC patientsDefinitive radiation therapyMedian radiation doseKaplan-Meier methodCumulative incidence functionFree survivalAdvanced headMedian ageMedian dosesNeck cancerAUC 1Radiation therapyCarboplatinPatientsChemoradiationPaclitaxelRadiation doseExcellent optionIncidence function
2019
Outcomes of multimodal therapy in a large series of patients with anaplastic thyroid cancer
Fan D, Ma J, Bell AC, Groen AH, Olsen KS, Lok BH, Leeman JE, Anderson E, Riaz N, McBride S, Ganly I, Shaha AR, Sherman EJ, Tsai CJ, Kang JJ, Lee NY. Outcomes of multimodal therapy in a large series of patients with anaplastic thyroid cancer. Cancer 2019, 126: 444-452. PMID: 31593317, PMCID: PMC7302673, DOI: 10.1002/cncr.32548.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsChemoradiotherapy, AdjuvantDose-Response Relationship, RadiationDoxorubicinFemaleFollow-Up StudiesHumansIndazolesMaleMiddle AgedPaclitaxelProgression-Free SurvivalPyrimidinesRadiotherapy DosageRadiotherapy, Intensity-ModulatedRetrospective StudiesSulfonamidesThyroid Carcinoma, AnaplasticThyroid GlandThyroid NeoplasmsThyroidectomyTumor BurdenConceptsLocoregional progression-free survivalRole of radiotherapyAnaplastic thyroid cancerTreatment of patientsOverall survivalAdverse eventsMetastatic diseaseTrimodal therapyThyroid cancerAcute grade 3 adverse eventsAdvanced anaplastic thyroid cancerGrade 3 adverse eventsPostoperative RTDistant metastasis-free survivalTrimodal treatment approachAcceptable toxicity profileProgression-free survivalLate adverse eventsLocal tumor controlMetastasis-free survivalLong-term outcomesLPFS ratesOS benefitConcurrent chemoradiationSystemic agents