2022
Differing effects of oral conjugated equine estrogen and transdermal estradiol on vitamin D metabolism in postmenopausal women: a 4-year longitudinal study
Santoro AM, Simpson CA, Cong E, Haas A, Sullivan RR, Parziale S, Deng Y, Insogna KL. Differing effects of oral conjugated equine estrogen and transdermal estradiol on vitamin D metabolism in postmenopausal women: a 4-year longitudinal study. Menopause The Journal Of The North American Menopause Society 2022, 29: 1200-1203. PMID: 35969885, DOI: 10.1097/gme.0000000000002045.Peer-Reviewed Original ResearchConceptsTransdermal estradiol groupConjugated equine estrogensVitamin D metabolismTransdermal estradiolEquine estrogensPostmenopausal womenEstradiol groupTreatment armsD metabolismVitamin DD levelsKronos Early Estrogen Prevention StudyConjugated equine estrogen groupOral conjugated equine estrogenVitamin D insufficientLeast square mean valuesEstrogen groupMicronized progesteroneEstrogen replacementPrevention StudySignificant treatment effectStudy groupTreatment groupsShort-term benefitsTreatment assignmentThe clinician’s guide to prevention and treatment of osteoporosis
LeBoff M, Greenspan S, Insogna K, Lewiecki E, Saag K, Singer A, Siris E. The clinician’s guide to prevention and treatment of osteoporosis. Osteoporosis International 2022, 33: 2049-2102. PMID: 35478046, PMCID: PMC9546973, DOI: 10.1007/s00198-021-05900-y.Peer-Reviewed Original ResearchConceptsTreatment of osteoporosisClinician's GuideVertebral fracturesFracture riskElevated riskCommon metabolic bone diseaseSubclinical vertebral fracturesAvoidance of smokingHigh-risk womenExpert clinical experiencePrimary care providersExcessive alcohol intakeFuture fracture riskNational Osteoporosis FoundationAdditional vertebral fracturesMetabolic bone diseaseDXA T-scoresAdult healthcare settingsDiagnosis of osteoporosisResistance training exercisesSignificant economic tollIncident fracturesNormal BMDUntreated osteoporosisPostmenopausal women
2021
Update on Osteoporosis Screening and Management
Anam AK, Insogna K. Update on Osteoporosis Screening and Management. Medical Clinics Of North America 2021, 105: 1117-1134. PMID: 34688418, DOI: 10.1016/j.mcna.2021.05.016.ChaptersConceptsLimited alcohol intakeNew anabolic therapiesLow bone massDual-energy X-ray absorptiometry measurementsBone mineral densityMetabolic bone diseasePostmenopausal womenAnabolic therapyFragility fracturesMicroarchitectural deteriorationSevere osteoporosisBone healthAlcohol intakeOsteoporosis screeningSmoking cessationVitamin DMineral densityPharmacologic agentsBone massBone diseaseHigh riskAbsorptiometry measurementsGold standardOsteoporosisBone tissue
2020
Epidemiology, Pathophysiology, and Genetics of Primary Hyperparathyroidism
Minisola S, Arnold A, Belaya Z, Brandi ML, Clarke BL, Hannan FM, Hofbauer LC, Insogna KL, Lacroix A, Liberman U, Palermo A, Pepe J, Rizzoli R, Wermers R, Thakker RV. Epidemiology, Pathophysiology, and Genetics of Primary Hyperparathyroidism. Journal Of Bone And Mineral Research 2020, 37: 2315-2329. PMID: 36245271, PMCID: PMC10092691, DOI: 10.1002/jbmr.4665.Peer-Reviewed Original ResearchConceptsPrimary hyperparathyroidismFamilial hypocalciuric hypercalcemiaMultiple endocrine neoplasia syndromeCalcium-containing kidney stonesIntestinal calcium hyperabsorptionMore parathyroid glandsParathyroid hormone levelsAsymptomatic primary hyperparathyroidismCalcium-sensing receptorEndocrine neoplasia syndromeNeonatal severe hyperparathyroidismHyperparathyroidism-jaw tumor syndromeJaw tumor syndromeCalcium hyperabsorptionPostmenopausal womenSevere hyperparathyroidismParathyroid hormoneSerum calciumHypocalciuric hypercalcemiaPathophysiologic basisParathyroid cellsParathyroid glandsHormone levelsFiltered loadMetabolic factors
2018
Associations among circulating colony-stimulating factor-1, estrogen, and bone mineral density in postmenopausal women
Haas AV, Cong E, Simpson CA, Sukumar N, Deng Y, Insogna KL. Associations among circulating colony-stimulating factor-1, estrogen, and bone mineral density in postmenopausal women. Menopause The Journal Of The North American Menopause Society 2018, 25: 197-201. PMID: 28816930, DOI: 10.1097/gme.0000000000000974.Peer-Reviewed Original ResearchConceptsBone mineral densityEstrogen-deficient womenMineral densityBone lossColony-stimulating factor-1Kronos Early Estrogen Prevention StudyPostmenopausal bone lossPlacebo-controlled studyOsteoclastic bone resorptionFactor 1CSF-1 levelsCSF-1Estrogen replacementEstrogen therapyPlacebo groupPostmenopausal womenCardiovascular endpointsSerum levelsFemoral neckBone resorptionPrevention StudyAncillary studiesTreatment groupsWomenSignificant correlation
2016
Effect of a randomized controlled exercise trial on bone outcomes: influence of adjuvant endocrine therapy
Knobf MT, Jeon S, Smith B, Harris L, Kerstetter J, Thompson AS, Insogna K. Effect of a randomized controlled exercise trial on bone outcomes: influence of adjuvant endocrine therapy. Breast Cancer Research And Treatment 2016, 155: 491-500. PMID: 26850265, DOI: 10.1007/s10549-016-3693-3.Peer-Reviewed Original ResearchConceptsFemale cancer survivorsPhysical activity groupEndocrine therapyBone outcomesExercise interventionBone lossFemoral neckAromatase inhibitorsActivity groupAdjuvant AI therapyChemotherapy-induced menopauseSufficient serum levelsAdjuvant endocrine therapyVitamin D supplementsHealthy postmenopausal womenLess bone lossHome-based groupSignificant BMD lossSignificant clinical problemMajority of subjectsAI therapyD supplementsPostmenopausal womenBMD lossBMD outcomes
2015
Dietary Protein and Vitamin D Intake and Risk of Falls: A Secondary Analysis of Postmenopausal Women from the Study of Osteoporotic Fractures
Larocque SC, Kerstetter JE, Cauley JA, Insogna KL, Ensrud K, Lui LY, Allore HG. Dietary Protein and Vitamin D Intake and Risk of Falls: A Secondary Analysis of Postmenopausal Women from the Study of Osteoporotic Fractures. Journal Of Nutrition In Gerontology And Geriatrics 2015, 34: 305-318. PMID: 26267443, PMCID: PMC4547350, DOI: 10.1080/21551197.2015.1054574.Peer-Reviewed Original ResearchConceptsVitamin D intakeVitamin DD intakePostmenopausal womenOsteoporotic fracturesDietary proteinOdds ratioOlder adultsFood frequency questionnaireRisk of fallsOccurrence of fallsIncident fallsFrequency questionnaireProspective cohortHip fractureMusculoskeletal healthInadequate intakeAdequate intakeOlder womenProtein intakeMuscle massSecondary analysisLogistic regressionIntakeWomenEffects of dietary glycaemic properties on markers of inflammation, insulin resistance and body composition in postmenopausal women
Stojkovic V, Simpson C, Sullivan R, Cusano A, Insogna K, Bihuniak J. Effects of dietary glycaemic properties on markers of inflammation, insulin resistance and body composition in postmenopausal women. Endocrine Abstracts 2015 DOI: 10.1530/endoabs.37.gp.13.03.Peer-Reviewed Original ResearchThe Effect of Dietary Glycemic Properties on Markers of Inflammation, Insulin Resistance and Body Composition in Postmenopausal Women
Bihuniak J, Stojkovic V, Simpson C, Sullivan R, Cusano A, Insogna K. The Effect of Dietary Glycemic Properties on Markers of Inflammation, Insulin Resistance and Body Composition in Postmenopausal Women. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.lb235.Peer-Reviewed Original ResearchMarkers of inflammationGI/GLInsulin resistanceBody compositionPostmenopausal womenLean massPRO groupGlycemic load dietTruncal lean massLow-grade inflammationTotal lean massTotal fat massLean body massWhey protein supplementLoad dietSerum CRPHigher BMIFood recordsIL-6Fat massChronic illnessInflammationOlder adultsFat ratioMonths
2013
Dietary Protein-Induced Increases in Urinary Calcium Are Accompanied by Similar Increases in Urinary Nitrogen and Urinary Urea: A Controlled Clinical Trial
Bihuniak JD, Simpson CA, Sullivan RR, Caseria DM, Kerstetter JE, Insogna KL. Dietary Protein-Induced Increases in Urinary Calcium Are Accompanied by Similar Increases in Urinary Nitrogen and Urinary Urea: A Controlled Clinical Trial. Journal Of The Academy Of Nutrition And Dietetics 2013, 113: 447-451. PMID: 23438496, PMCID: PMC5868414, DOI: 10.1016/j.jand.2012.11.002.Peer-Reviewed Original ResearchConceptsBone turnover markersDietary protein intakeUrinary creatinineUrinary calciumProtein intakeUrinary ureaTurnover markersUrinary nitrogenNutrition intervention trialMaltodextrin controlPostmenopausal womenIntervention trialsClinical trialsUrinary metabolitesCreatinineDay 0Whey supplementationWhey supplementsIntakeSample t-testSimilar increaseTrialsT-testSupplementationMarkers
2011
Using urinary nitrogen and urea to predict dietary protein intake: a controlled clinical trial
Bihuniak J, Simpson C, Sullivan R, Kerstetter J, Insogna K. Using urinary nitrogen and urea to predict dietary protein intake: a controlled clinical trial. The FASEB Journal 2011, 25: 600.3-600.3. DOI: 10.1096/fasebj.25.1_supplement.600.3.Peer-Reviewed Original ResearchProtein intakeSupplementation trialWhey supplementationUrinary ureaBone turnover markersDietary protein intakeBone mineral densityPostmenopausal womenTurnover markersBone turnoverClinical trialsMineral densityUCreatDay 0Urine nitrogenWhey supplementsOutcome variablesIntakeTrialsMaltodextrin supplementUrinary nitrogenBone centersSupplementationSupplementsCostly alternative
2003
Torus Palatinus: A New Anatomical Correlation with Bone Density in Postmenopausal Women
Belsky JL, Hamer JS, Hubert JE, Insogna K, Johns W. Torus Palatinus: A New Anatomical Correlation with Bone Density in Postmenopausal Women. The Journal Of Clinical Endocrinology & Metabolism 2003, 88: 2081-2086. PMID: 12727958, DOI: 10.1210/jc.2002-021726.Peer-Reviewed Original ResearchConceptsBone densityTorus palatinusPostmenopausal womenZ-scoreDual energy x-ray absortiometryNormal postmenopausal womenPostmenopausal female subjectsBody mass indexBone mineral densityBone density measurementsBone density assessmentHigher bone densityMass indexCaucasian womenMineral densityCommunity physiciansUnselected populationAnatomical correlationLumbar vertebraeFemale subjectsDensity assessmentPalatinusOral exostosesWomenPossible correlation
2002
Evidence that the IL-6/IL-6 Soluble Receptor Cytokine System Plays a Role in the Increased Skeletal Sensitivity to PTH in Estrogen-Deficient Women
Masiukiewicz US, Mitnick M, Gulanski BI, Insogna KL. Evidence that the IL-6/IL-6 Soluble Receptor Cytokine System Plays a Role in the Increased Skeletal Sensitivity to PTH in Estrogen-Deficient Women. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 2892-2898. PMID: 12050269, DOI: 10.1210/jcem.87.6.8577.Peer-Reviewed Original ResearchConceptsEstrogen-deficient womenIL-6/ILSkeletal sensitivityIL-6IL-6sREstrogen deficiencyCytokine systemIL-6 soluble receptorUrine N-telopeptideAction of PTHPrevious animal studiesNTx excretionPTH infusionPostmenopausal womenSerum calciumN-telopeptideCytokine productionTNF-alphaExaggerated increaseIL-1betaHormonal statusBaseline valuesSoluble receptorAnimal studiesColony-stimulating factor-1
1998
The role of parathyroid hormone in the pathogenesis, prevention and treatment of postmenopausal osteoporosis
Masiukiewicz US, Insogna KL. The role of parathyroid hormone in the pathogenesis, prevention and treatment of postmenopausal osteoporosis. Aging Clinical And Experimental Research 1998, 10: 232-239. PMID: 9801733, DOI: 10.1007/bf03339657.Peer-Reviewed Original ResearchConceptsParathyroid hormonePostmenopausal womenPrimary hyperparathyroidismBone lossSecondary hyperparathyroidismAnabolic therapyPostmenopausal osteoporosisBone massVitamin D. Parathyroid hormoneDaily subcutaneous administrationRecent therapeutic trialsVitamin D metabolismTrabecular bone massTherapeutic trialsD metabolismBone turnoverBone resorptionSurgical correctionSubcutaneous administrationHyperparathyroidismVivo effectsSingle agentTissue responsivenessSustained increaseCortical sites
1996
Boning Up on Estrogen: New Options, New Concerns
Insogna K, Concato J, Henrich J. Boning Up on Estrogen: New Options, New Concerns. JAMA 1996, 276: 1430-1432. DOI: 10.1001/jama.1996.03540170074037.Peer-Reviewed Original ResearchHormone replacement therapyPostmenopausal osteoporosisOral hormone replacement therapyRegular uterine bleedingInitiation of treatmentLong-term adherenceAlternative regimenEstrogen replacementPostmenopausal womenUterine bleedingProgestational agentsIntermittent administrationBone lossReplacement therapyOnly drugBone breakdownFracture ratesEstrogenWomenOsteoporosisDaily useNew optionsRecent studiesTreatmentBleeding
1994
Optimal Calcium Intake
Bilezikian J, Bailey L, Elmer P, Favus M, Go V, Goldring S, Holt L, Insogna K, Krimgold B, Mallette L, Shapiro J, St. Jeor S, Stern P, Tilley B, Yamamoto M, Abrams S, Ascherio A, Baron J, Bell N, Chrischilles E, Dawson-Hughes B, Heaney R, Holick M, Johnston C, Kleerekoper M, Lemann J, Levine R, Lindsay R, Looker A, Love B, Marcus R, Matkovic V, Melton L, Meunier P, Navia J, Nelson D, Orwoll E, Peck W, Recker R, Resnick L, Riggs B, Singer F, Slemenda C, Sowers M, Weaver C, Miller S, Willett W, Shulman L, Ben-Ari E, Bray E, Calvo M, Ernst N, Ferguson J, Grave G, Haddad J, Hall W, Heyse S, Hubbard V, McGowan J, Perloff M, Pollack E, Reford M, Stark-Reed P. Optimal Calcium Intake. JAMA 1994, 272: 1942-1948. DOI: 10.1001/jama.1994.03520240070044.Peer-Reviewed Original ResearchOptimal peak bone massPeak bone massCalcium intakeBone massOptimal calcium intakeAdequate calcium intakeIntake of calciumOccurrence of osteoporosisConsensus Development ConferenceDecades of lifeHealth care systemMajor underlying causePostmenopausal womenBone lossBone fracturesUS populationOsteoporosisUnderlying causeCare systemIntakeDevelopment ConferencePossible roleFracturesPrevious surveysYears