2022
Mapping and Validation of scRNA-Seq-Derived Cell-Cell Communication Networks in the Tumor Microenvironment
Bridges K, Miller-Jensen K. Mapping and Validation of scRNA-Seq-Derived Cell-Cell Communication Networks in the Tumor Microenvironment. Frontiers In Immunology 2022, 13: 885267. PMID: 35572582, PMCID: PMC9096838, DOI: 10.3389/fimmu.2022.885267.Peer-Reviewed Original ResearchMeSH KeywordsCell CommunicationGene Expression ProfilingSequence Analysis, RNASingle-Cell AnalysisTumor MicroenvironmentConceptsScRNA-seqHigh-throughput transcriptional profilingCell-cell communication networksSingle-cell RNA sequencingCell-cell communicationSingle-cell technologiesCell-cell interactionsTumor microenvironmentTranscriptional profilingInteraction networksRNA sequencingBiological systemsNetwork analysisComputational approach
2016
Redefining Signaling Pathways with an Expanding Single-Cell Toolbox
Gaudet S, Miller-Jensen K. Redefining Signaling Pathways with an Expanding Single-Cell Toolbox. Trends In Biotechnology 2016, 34: 458-469. PMID: 26968612, PMCID: PMC4958913, DOI: 10.1016/j.tibtech.2016.02.009.Peer-Reviewed Original ResearchConceptsSignaling pathwaysSingle-cell toolsDNA damage responseCanonical signaling pathwaysSingle-cell measurementsNovel mechanistic insightsCell variabilityStress responseBiological informationAnalytical pipelineEnvironmental stimuliImaging-based approachIdentical cellsCell proliferationMechanistic insightsSingle cellsRecent technological advancesPathwayCellsUnderlying mechanismVivo applicabilityCell responsesResponseProliferationCell measurements