2017
Longitudinal analysis of quality‐of‐life outcomes in children during treatment for acute lymphoblastic leukemia: A report from the Children's Oncology Group AALL0932 trial
Zheng DJ, Lu X, Schore RJ, Balsamo L, Devidas M, Winick NJ, Raetz EA, Loh ML, Carroll WL, Sung L, Hunger SP, Angiolillo AL, Kadan‐Lottick N. Longitudinal analysis of quality‐of‐life outcomes in children during treatment for acute lymphoblastic leukemia: A report from the Children's Oncology Group AALL0932 trial. Cancer 2017, 124: 571-579. PMID: 29112230, PMCID: PMC5808870, DOI: 10.1002/cncr.31085.Peer-Reviewed Original ResearchConceptsAverage-risk acute lymphoblastic leukemiaQuality of lifeEmotional impairmentsLife Inventory (PedsQL) Generic CoreHigh-risk patientsProspective cohort studyTime of diagnosisEnd of therapyAcute lymphoblastic leukemiaFamily-based interventionsCohort studyQoL impairmentMean ageLymphoblastic leukemiaQOL outcomesPediatric QualityProportion of individualsEarly screeningPopulation normsImpaired rangeImpairmentMonthsTime pointsFunctioning impairmentImpairment patternsLongitudinal analysis of quality of life outcomes in children during treatment for acute lymphoblastic leukemia: A report from the Children’s Oncology Group (COG) AALL0932.
Zheng D, Lu X, Ross W, Angiolillo A, Schore R, Balsamo L, Devidas M, Whitley M, Kadan-Lottick N. Longitudinal analysis of quality of life outcomes in children during treatment for acute lymphoblastic leukemia: A report from the Children’s Oncology Group (COG) AALL0932. Journal Of Clinical Oncology 2017, 35: 10522-10522. DOI: 10.1200/jco.2017.35.15_suppl.10522.Peer-Reviewed Original ResearchAverage-risk acute lymphoblastic leukemiaQuality of lifeAcute lymphoblastic leukemiaLymphoblastic leukemiaEmotional functioningMulti-agent chemotherapyEvent-free survivalModifiable risk factorsFrequent hospital visitsEmotional impairmentsMedian ageHospital visitsPattern of impairmentQOL outcomesRisk factorsPainful proceduresFamily functioningProportion of individualsEarly screeningSevere impairmentPopulation normsPotential predictorsImpaired rangeLife outcomesMonths
2016
Prevalence and predictors of anxiety and depression after completion of chemotherapy for childhood acute lymphoblastic leukemia: A prospective longitudinal study
Kunin-Batson AS, Lu X, Balsamo L, Graber K, Devidas M, Hunger SP, Carroll WL, Winick NJ, Mattano LA, Maloney KW, Kadan-Lottick NS. Prevalence and predictors of anxiety and depression after completion of chemotherapy for childhood acute lymphoblastic leukemia: A prospective longitudinal study. Cancer 2016, 122: 1608-1617. PMID: 27028090, PMCID: PMC4860039, DOI: 10.1002/cncr.29946.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCompletion of treatmentGreater riskEmotional-behavioral functioningChildren's Oncology Group protocolsChildhood acute lymphoblastic leukemiaAdjusted longitudinal analysesCompletion of chemotherapyDepressive symptoms 6 monthsSymptoms 6 monthsEmotional distressElevated anxiety scoresAnxiety 1 monthStandardized rating scalesElevated depression scoresChildren's emotional-behavioral functioningLymphoblastic leukemiaPredictors of anxietySocial support copingMeasures of copingDepressive symptomsGeneral populationDepression scoresPsychosocial interventionsEarly screening