2023
Sis2 regulates yeast replicative lifespan in a dose-dependent manner
Ölmez T, Moreno D, Liu P, Johnson Z, McGinnis M, Tu B, Hochstrasser M, Acar M. Sis2 regulates yeast replicative lifespan in a dose-dependent manner. Nature Communications 2023, 14: 7719. PMID: 38012152, PMCID: PMC10682402, DOI: 10.1038/s41467-023-43233-y.Peer-Reviewed Original ResearchMeSH KeywordsCell CycleCell Cycle ProteinsDNA ReplicationLongevitySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsConceptsYeast replicative lifespanReplicative lifespanRNA-seq experimentsCoenzyme A biosynthesis pathwayYeast lifespanYeast strainsStrain librariesLifespan regulationRNA-seqGene networksDose-dependent mannerLifespan extensionTranscriptional increaseYeastLifespan measurementsWild-typeGenesMachinery componentsStrainMicrofluidic platformApplications of microfluidic platformsLifespanDeletionCoenzymePathway
1983
Properties of the T4 bacteriophage DNA replication apparatus: The T4 dda DNA helicase is required to pass a bound RNA polymerase molecule
Bedinger P, Hochstrasser M, Jongeneel C, Alberts B. Properties of the T4 bacteriophage DNA replication apparatus: The T4 dda DNA helicase is required to pass a bound RNA polymerase molecule. Cell 1983, 34: 115-123. PMID: 6136341, DOI: 10.1016/0092-8674(83)90141-1.Peer-Reviewed Original ResearchConceptsRNA polymerase moleculesE. coli RNA polymeraseColi RNA polymerasePolymerase moleculesDNA helicaseReplication forksRNA polymeraseDNA replication apparatusDNA replication systemReplication apparatusDNA replicationFork movementReplication complexDNA templateReplication systemHelicaseTranscriptionPolymeraseForkMoleculesGenesPromoterProteinDNASlower rate