Featured Publications
Translocation of a gut pathobiont drives autoimmunity in mice and humans
Vieira S, Hiltensperger M, Kumar V, Zegarra-Ruiz D, Dehner C, Khan N, Costa FRC, Tiniakou E, Greiling T, Ruff W, Barbieri A, Kriegel C, Mehta SS, Knight JR, Jain D, Goodman AL, Kriegel MA. Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science 2018, 359: 1156-1161. PMID: 29590047, PMCID: PMC5959731, DOI: 10.1126/science.aar7201.Peer-Reviewed Original ResearchConceptsGut pathobiontAutoimmune-prone miceMurine findingsIntramuscular vaccinePathogenic autoantibodiesLiver biopsyAutoimmune responseAutoimmune patientsAntibiotic treatmentT cellsImmune diseasesAutoimmunitySusceptible humansPathobiontsSystemic tissuesHuman hepatocytesAutoantibodiesMortalityMiceCocultureHepatocytesGenetic backgroundTissueBiopsyPatients
2017
Spontaneous Translocation of a Gut Pathobiont Drives Autoimmunity that is Preventable by Intramuscular Vaccination
Vieira S, Hiltensperger M, Kumar V, Dehner C, Zegarra-Ruiz D, Ruff W, Khan N, Goodman A, Kriegel M. Spontaneous Translocation of a Gut Pathobiont Drives Autoimmunity that is Preventable by Intramuscular Vaccination. The Journal Of Immunology 2017, 198: 199.20-199.20. DOI: 10.4049/jimmunol.198.supp.199.20.Peer-Reviewed Original ResearchMesenteric lymph nodesGut microbiotaE. gallinarumGerm-free (GF) C57BL/6 miceAutoimmune hepatitis patientsInduction of autoantibodiesPathogenesis of autoimmunityNovel therapeutic avenuesTfh cellsDietary antigensIntramuscular vaccineIntramuscular vaccinationHepatitis patientsLymph nodesGut barrierHost-microbiota interactionsOral gavageC57BL/6 miceSystemic autoimmunityPortal veinTherapeutic avenuesAutoimmunitySingle antibioticLiver tissueMice