Paula Kavathas, PhD
Professor of Laboratory Medicine, of Immunobiology and of Molecular, Cellular, and Developmental BiologyCards
Appointments
Additional Titles
Vice Chair for Diversity, Equity and Inclusion, Laboratory Medicine
Vice Chair of Diversity, Immunobiology
Institutional Leader, CIRTL Network, CIRTL Network
Contact Info
Appointments
Additional Titles
Vice Chair for Diversity, Equity and Inclusion, Laboratory Medicine
Vice Chair of Diversity, Immunobiology
Institutional Leader, CIRTL Network, CIRTL Network
Contact Info
Appointments
Additional Titles
Vice Chair for Diversity, Equity and Inclusion, Laboratory Medicine
Vice Chair of Diversity, Immunobiology
Institutional Leader, CIRTL Network, CIRTL Network
Contact Info
About
Titles
Professor of Laboratory Medicine, of Immunobiology and of Molecular, Cellular, and Developmental Biology
Vice Chair for Diversity, Equity and Inclusion, Laboratory Medicine; Vice Chair of Diversity, Immunobiology
Positions outside Yale
Institutional Leader, CIRTL Network, CIRTL Network
Biography
Dr. Kavathas studies the T cell co-receptor CD8ab and the functional significance of four isoforms of the human CD8b protein that exist in humans and great apes but not mice. More recently she is studying the basis for acquired resistance to immunotherapy of human lung cancer tumors.
Dr. Kavathas is currently Vice Chair of Diversity for both the Departments of Immunobiology and of Laboratory Medicine. She is on the board of Status of Women in Medicine, SWIM, and of the Women’s Faculty Forum, WFF, (Chair from 2013-2017). She played a role in diversifying portraits at Yale including commissioning a portrait of the first women PhDs located in the nave of Sterling library. Other activities include co-organizing a conference entitled “Gender Rules,” publication of The View (a demographic analysis of women and URMs at Yale), expansion of the Phyllis Bodel Childcare Center, and changes in parental leave policies.
Appointments
Laboratory Medicine
ProfessorPrimaryImmunobiology
ProfessorSecondary
Other Departments & Organizations
Education & Training
- PhD
- University of Wisconsin-Madison (1980)
- BA
- University of Wisconsin-Madison (1972)
Research
Overview
Medical Subject Headings (MeSH)
Research at a Glance
Yale Co-Authors
Shana Leopold, PhD
Publications
2024
Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease
Zhou X, Shen X, Johnson J, Spakowicz D, Agnello M, Zhou W, Avina M, Honkala A, Chleilat F, Chen S, Cha K, Leopold S, Zhu C, Chen L, Lyu L, Hornburg D, Wu S, Zhang X, Jiang C, Jiang L, Jiang L, Jian R, Brooks A, Wang M, Contrepois K, Gao P, Rose S, Tran T, Nguyen H, Celli A, Hong B, Bautista E, Dorsett Y, Kavathas P, Zhou Y, Sodergren E, Weinstock G, Snyder M. Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease. Cell Host & Microbe 2024, 32: 506-526.e9. PMID: 38479397, PMCID: PMC11022754, DOI: 10.1016/j.chom.2024.02.012.Peer-Reviewed Original ResearchCitationsAltmetricConceptsHost healthMicrobiome dynamicsBacterial taxaBody sitesMicrobiome stabilityIndividual taxaHuman microbiomeMicrobial compositionMicrobial dynamicsMulti-omicsNasal microbiomeMicrobiomeDisrupt interactionsMolecular markersBody-sitesTaxaHostMetabolic diseasesOral microbiomeInsulin-resistant individualsIndividual-specificTemporal dynamicsClinical featuresComprehensive viewClinical markers
1993
Identification and Characterization of an Alu-Containing, T-Cell-Specific Enhancer Located in the Last Intron of the Human CD8α Gene
Hambor J, Mennone J, Coon M, Hanke J, Kavathas P. Identification and Characterization of an Alu-Containing, T-Cell-Specific Enhancer Located in the Last Intron of the Human CD8α Gene. Molecular And Cellular Biology 1993, 13: 7056-7070. DOI: 10.1128/mcb.13.11.7056-7070.1993.Peer-Reviewed Original ResearchConceptsT cell-specific enhancerLyF-1Regulatory elementsHypersensitive sitesBinding sitesCD8A geneDNase I hypersensitivity mappingCis-acting regulatory regionsEts-1Consensus binding siteElectrophoretic mobility shift assayNegative regulatory elementDNA sequence analysisSite-directed mutationsGATA-3 sitesReduced enhancer activityMobility shift assayTissue-specific expressionGATA-3Combinations of mutationsBHLH proteinsAlu repeatsChromatin structureT cell genesRegulatory regions
Links & Media
News
- October 15, 2021Source: Yale Daily News
LATINX SPECIAL ISSUE: Marietta Vazquez first Latina named YSM assoc. Dean
- October 29, 2020Source: Yale Daily News
Yale Medicine Board elects new female chair, four new members
- April 14, 2020Source: Veoci
Coronavirus: Immunity to Viruses
- November 20, 2019
Yale Researchers Publish New Book: "Immunoepidemiology"
Get In Touch
Contacts
Locations
kavathas
Lab
The Anlyan Center
300 Cedar Street, Ste S540
New Haven, CT 06519
Appointments
203.785.6223