2024
Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)
Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.Peer-Reviewed Original ResearchConceptsRandomized phase II trialCD4/CD8 T cellsT cellsHPV clearanceArm BNo significant differenceClinical surveillanceRate of HPV clearanceSecondary outcomesPre-neoplastic cervical lesionsCervical intraepithelial neoplasiaT cell infiltrationT cell responsesSignificant differenceCIN3 patientsIntraepithelial neoplasiaArm ACervical lesionsImiquimod groupSurveillance armVaginal suppositoriesProspective trialsArm CHPV vaccinationImiquimod
2016
A Comparison of the Roche Cobas HPV Test With the Hybrid Capture 2 Test for the Detection of High-Risk Human Papillomavirus Genotypes
Levi AW, Bernstein JI, Hui P, Duch K, Schofield K, Chhieng DC. A Comparison of the Roche Cobas HPV Test With the Hybrid Capture 2 Test for the Detection of High-Risk Human Papillomavirus Genotypes. Archives Of Pathology & Laboratory Medicine 2016, 140: 153-7. PMID: 26910220, DOI: 10.5858/arpa.2015-0027-oa.Peer-Reviewed Original ResearchMeSH KeywordsDNA, ViralFemaleGenotypeHumansIn Situ HybridizationMolecular Diagnostic TechniquesPapillomaviridaePapillomavirus InfectionsReal-Time Polymerase Chain ReactionVaginal SmearsConceptsHigh-risk human papillomavirusHuman papillomavirus assaysCobas human papillomavirus (HPV) testHigh-risk human papillomavirus DNAHybrid Capture 2 testHuman papillomavirus testingHuman papillomavirus testHuman papillomavirus DNAHuman papillomavirusPapillomavirus DNAHigh-risk human papillomavirus genotypesRoche cobas HPV testRoche CobasSurePath preparationsThinPrep specimensDiscordant resultsHybrid captureCobas HPV TestHuman papillomavirus resultsLiquid-based cytology samplesHybrid Capture 2Human papillomavirus genotypesLiquid-based preparationsHPV testCapture 2
2015
Grading of atypia in genital skin lesions: routine microscopic evaluation and use of p16 immunostaining
Ezaldein H, Lott JP, McNiff JM, Hui P, Buza N, Ko CJ. Grading of atypia in genital skin lesions: routine microscopic evaluation and use of p16 immunostaining. Journal Of Cutaneous Pathology 2015, 42: 519-526. PMID: 25951050, DOI: 10.1111/cup.12525.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCross-Sectional StudiesCyclin-Dependent Kinase Inhibitor p16FemaleGenitalia, FemaleHumansImmunohistochemistryMaleMiddle AgedNeoplasm ProteinsObserver VariationPapillomavirus InfectionsSensitivity and SpecificitySkin DiseasesSquamous Intraepithelial Lesions of the CervixUterine Cervical NeoplasmsConceptsGenital skin lesionsHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsSquamous intraepithelial lesionsP16 immunostainingSkin lesionsDiagnostic agreementIntraepithelial lesionsUseful adjunctive markerHigh-grade dysplasiaCross-sectional studyRoutine microscopic evaluationDegree of atypiaAdjunctive markerInter-observer agreementPrimary outcomeCervical lesionsHistopathologic assessmentHistopathologic evaluationConsensus diagnosisReactive atypiaEosin stainingOriginal diagnosisAtypiaLesions
2011
Use of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions
Levi AW, Harigopal M, Hui P, Schofield K, Chhieng DC. Use of high‐risk human papillomavirus testing in patients with low‐grade squamous intraepithelial lesions. Cancer Cytopathology 2011, 119: 228-234. PMID: 21732551, DOI: 10.1002/cncy.20172.Peer-Reviewed Original ResearchConceptsLow-grade squamous intraepithelial lesionsHR-HPV testingHPV testingCIN 2Colposcopy rateHR-HPVRelative light units/cutoffCervical intraepithelial neoplasia 2High-risk human papillomavirusHR-HPV statusRLU/COIntraepithelial neoplasia 2Hybrid Capture 2Squamous intraepithelial lesionsCIN 1 lesionsLarge teaching hospitalNegative predictive valueLSIL cytologyHPV statusIntraepithelial lesionsCapture 2Human papillomavirusTeaching hospitalCytologic diagnosisSevere lesions