2024
Cutting Edge: Phagosome-associated Autophagosomes Containing Antigens and Proteasomes Drive TAP-Independent Cross-Presentation.
Sengupta D, Galicia-Pereyra R, Han P, Graham M, Liu X, Arshad N, Cresswell P. Cutting Edge: Phagosome-associated Autophagosomes Containing Antigens and Proteasomes Drive TAP-Independent Cross-Presentation. The Journal Of Immunology 2024, 212: 1063-1068. PMID: 38353614, PMCID: PMC10948299, DOI: 10.4049/jimmunol.2200446.Peer-Reviewed Original ResearchCross-presentationTransporter associated with Ag processingExogenous AgCD8-positive T lymphocytesAntigenic peptidesMHC-I moleculesDendritic cellsProteasomal deliveryT lymphocytesCytosolic proteasomeActive proteasomesEndocytic compartmentsTAP-independentLumen of phagosomesSubcellular compartmentsEndoplasmic reticulumEndolysosomal vesiclesMHC-IAg processingBind to MHC-IProteasome
1999
Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells
Tomazin R, Boname J, Hegde N, Lewinsohn D, Altschuler Y, Jones T, Cresswell P, Nelson J, Riddell S, Johnson D. Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells. Nature Medicine 1999, 5: 1039-1043. PMID: 10470081, DOI: 10.1038/12478.Peer-Reviewed Original ResearchConceptsHuman cytomegalovirusT cellsT lymphocytesClass II proteinsMHC class II antigen presentation pathwayMHC class II pathwayClass II antigen presentation pathwayHCMV-infected macrophagesAntigen presentation pathwayClass II pathwayLifelong latent infectionLife-threatening diseaseMonocytes/macrophagesMHC class IImportant host cellsMHC class II proteinsImmune evasion proteinsVirus reactivationHLA-DRLatent reservoirPresent antigensGlial cellsUbiquitous herpesvirusLatent infectionPresentation pathway
1990
Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding
Roche P, Cresswell P. Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding. Nature 1990, 345: 615-618. PMID: 2190094, DOI: 10.1038/345615a0.Peer-Reviewed Original ResearchConceptsClass II moleculesImmunogenic peptidesMHC moleculesClass II major histocompatibility complex moleculesClass II MHC moleculesMajor histocompatibility complex moleculesClass I MHC moleculesHLA-DR moleculesII MHC moleculesHistocompatibility complex moleculesI MHC moleculesClass I moleculesIntracellular class II moleculesCell surface expressionT lymphocytesPresent immunogenic peptidesClass IIProtein antigensClass IInvariant chain associationI moleculesCell surface glycoproteinSurface expressionInvariant chainFunctional dichotomy
1987
Antigen recognition by T lymphocytes
Cresswell P. Antigen recognition by T lymphocytes. Trends In Immunology 1987, 8: 67-69. PMID: 25289464, DOI: 10.1016/0167-5699(87)90843-7.Peer-Reviewed Original Research
1980
HLA-A2 as a target for cell-mediated lympholysis: Evidence from immunoselected HLA-A2 negative mutant cell lines
Andreotti P, Apgar J, Cresswell P. HLA-A2 as a target for cell-mediated lympholysis: Evidence from immunoselected HLA-A2 negative mutant cell lines. Human Immunology 1980, 1: 77-86. PMID: 7263311, DOI: 10.1016/0198-8859(80)90011-7.Peer-Reviewed Original ResearchConceptsCytotoxic T lymphocytesCell-mediated lympholysisHLA-A2T lymphocytesMixed lymphocyte responseHLA-A2 mutantsCell linesLymphocyte responsesHLA typingImmune precipitation analysisLymphocytesTarget cellsMolecular targetsSensitized cellsMutant cell linesComparable susceptibilityLympholysisHLAStaphylococcus aureus proteinPutative targetsAureus proteinNegative selectionCellsTargetSusceptibility
1977
Robbit antisera to human B cell alloantigens: Effects on the mixed lymphocyte response
Geier S, Cresswell P. Robbit antisera to human B cell alloantigens: Effects on the mixed lymphocyte response. Cellular Immunology 1977, 28: 341-354. PMID: 139207, DOI: 10.1016/0008-8749(77)90117-4.Peer-Reviewed Original ResearchConceptsMixed lymphocyte responseB-lymphoblastoid cell linesHuman B lymphoblastoid cell lineB-cell alloantigensLymphoblastoid cell linesT-lymphoblastoid cell lineLymphocyte responsesHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsPeripheral blood B lymphocytesHuman B cell alloantigensBlood B lymphocytesBlood mononuclear cellsHuman B cellsMononuclear cellsT lymphocytesB cellsB lymphocytesContinuous stimulationLymphocytesFab preparationsAlloantigensCell lines