2011
Stimulatory Lipids Accumulate in the Mouse Liver within 30 min of Contact Sensitization to Facilitate the Activation of Naïve iNKT Cells in a CD1d‐Dependent Fashion
Dey N, Szczepanik M, Lau K, Majewska‐Szczepanik M, Askenase PW. Stimulatory Lipids Accumulate in the Mouse Liver within 30 min of Contact Sensitization to Facilitate the Activation of Naïve iNKT Cells in a CD1d‐Dependent Fashion. Scandinavian Journal Of Immunology 2011, 74: 52-61. PMID: 21352253, DOI: 10.1111/j.1365-3083.2011.02540.x.Peer-Reviewed Original ResearchConceptsHepatic iNKT cellsINKT cellsContact sensitivityHepatic lipidsT cellsB cellsNatural killer T cellsAdoptive transfer techniquesEffector T cellsLiver mononuclear cellsCutaneous inflammatory responseINKT cell activationKiller T cellsMouse liverΑβ T cell receptorAllergic contact dermatitisInnate immune systemRecipient mouse liversSame allergenContact hypersensitivityTopical sensitizationContact sensitizationIgM antibodiesMononuclear cellsIL-4
2006
Interleukin 5 Plays an Essential Role in Elicitation of Contact Sensitivity through Dual Effects on Eosinophils and B-1 Cells
Itakura A, Kikuchi Y, Kouro T, Ikutani M, Takaki S, Askenase PW, Takatsu K. Interleukin 5 Plays an Essential Role in Elicitation of Contact Sensitivity through Dual Effects on Eosinophils and B-1 Cells. International Archives Of Allergy And Immunology 2006, 140: 8-16. PMID: 16772721, DOI: 10.1159/000092705.Peer-Reviewed Original ResearchConceptsElicitation of CSIgM-producing cellsContact sensitivityEosinophil peroxidase activityEosinophil infiltrationIL-5Antigen-specific immunoglobulin M antibodyCS-effector T cellsEnzyme-linked immunospot assayLocal tissueEffector T cellsRole of interleukinImmunoglobulin M antibodiesIL-5 receptorImmunized ILImmunospot assayContact sensitizationM antibodiesMononuclear cellsDeficient micePolymorphonuclear cellsT cellsImmune responseCell activationInterleukin-5
1977
Cuta neous basophil responses in neonatal guinea pigs: active immunization, hapten specific transfer with small amounts of serum, and preferential elicitation with phytohemagglutinin skin testing.
Haynes J, Askenase P. Cuta neous basophil responses in neonatal guinea pigs: active immunization, hapten specific transfer with small amounts of serum, and preferential elicitation with phytohemagglutinin skin testing. The Journal Of Immunology 1977, 118: 1063-9. PMID: 845431, DOI: 10.4049/jimmunol.118.3.1063.Peer-Reviewed Original ResearchConceptsNeonatal guinea pigsIncomplete Freund's adjuvantMononuclear cellsCutaneous basophil hypersensitivityGuinea pigsBasophil responsePPD reactionSkin testFreund's adjuvantDelayed skin test responsesDelayed hypersensitivity skin responseHapten-specific mannerNonimmune guinea pigsDelayed-type reactionsSkin test responsesInfiltration of eosinophilsAdult guinea pigsCutaneous basophil responseIntravenous transferCutaneous basophil hypersensitivity reactionNeonatal responsesAdult donorsCutaneous reactionsNeonatesHapten-carrier conjugates