2024
IL-10 constrains sphingolipid metabolism to limit inflammation
York A, Skadow M, Oh J, Qu R, Zhou Q, Hsieh W, Mowel W, Brewer J, Kaffe E, Williams K, Kluger Y, Smale S, Crawford J, Bensinger S, Flavell R. IL-10 constrains sphingolipid metabolism to limit inflammation. Nature 2024, 627: 628-635. PMID: 38383790, PMCID: PMC10954550, DOI: 10.1038/s41586-024-07098-5.Peer-Reviewed Original ResearchActivity of RelCeramide productionVery long chainFatty acid synthesis pathwayCeramide synthase 2Fatty acid homeostasisMetabolic fluxAvailable to cellsRegulatory nodesTranscription factorsCeramide accumulationSynthesis pathwayVLC ceramidesIL-10 deficiencyGene expressionSphingolipid metabolismAcid homeostasisAberrant activationIL-10Cell types1Innate immune cellsInflammatory gene expressionCeramideSignaling resultsGenetic deletion
2020
Evidence for a pathogenic role of extrafollicular, IL-10–producing CCR6+B helper T cells in systemic lupus erythematosus
Facciotti F, Larghi P, Bosotti R, Vasco C, Gagliani N, Cordiglieri C, Mazzara S, Ranzani V, Rottoli E, Curti S, Penatti A, Karnani B, Kobayashi Y, Crosti M, Bombaci M, van Hamburg JP, Rossetti G, Gualtierotti R, Gerosa M, Gatti S, Torretta S, Pignataro L, Tas SW, Abrignani S, Pagani M, Grassi F, Meroni PL, Flavell RA, Geginat J. Evidence for a pathogenic role of extrafollicular, IL-10–producing CCR6+B helper T cells in systemic lupus erythematosus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 7305-7316. PMID: 32184325, PMCID: PMC7132288, DOI: 10.1073/pnas.1917834117.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusHelper T cellsT cellsIL-10Pathogenic roleSLE patientsLupus erythematosusIL-7RB cellsPathogenic anti-dsDNA antibodiesFollicular helper T cellsAnti-dsDNA antibodiesLupus-like diseaseT cell populationsB cell responsesProduction ex vivoCytokine reporter miceProminent pathogenic roleImmunoglobulin G productionNaïve B cellsIL-17Antiinflammatory cytokinesLymph nodesInterleukin-10Peripheral blood