2024
JAK/STAT signaling pathway affects CCR5 expression in human CD4+ T cells
Wang L, Yukselten Y, Nuwagaba J, Sutton R. JAK/STAT signaling pathway affects CCR5 expression in human CD4+ T cells. Science Advances 2024, 10: eadl0368. PMID: 38507500, PMCID: PMC10954213, DOI: 10.1126/sciadv.adl0368.Peer-Reviewed Original ResearchConceptsCD4<sup>+</sup> T cellsT cellsCCR5 expressionPrimary CD4<sup>+</sup> T cellsCD4+ T cellsHuman CD4+ T cellsHuman primary CD4<sup>+</sup> T cellsGlucocorticoid-regulated kinase 1HIV cure agendaHIV co-receptorsSignaling pathwayCCR5 levelsJAK/STAT inhibitor tofacitinibViremic patientsHIV patientsHIV infectionInhibitor tofacitinibJAK/STAT signaling pathwayCCR5Co-receptorHIVProtein levelsCCR2/CCR5Adverse effectsDown-regulation
2003
HIV-based vectors for therapeutic angiogenesis in a rabbit model of hindlimb ischemia
Conklin L, LeMaire S, Coselli J, McAninch R, Sutton R. HIV-based vectors for therapeutic angiogenesis in a rabbit model of hindlimb ischemia. Journal Of Surgical Research 2003, 114: 284. DOI: 10.1016/j.jss.2003.08.045.Peer-Reviewed Original ResearchVascular endothelial-derived growth factorEndothelial-derived growth factorHindlimb ischemiaRabbit modelGrowth factorSurgical therapeutic optionsIpsilateral femoral arteryVessel collateralizationExternal iliac arteryNew Zealand white rabbitsNovel treatment modalitiesIschemic cardiovascular diseaseZealand white rabbitsPOD 40Ipsilateral thighTherapeutic optionsUnderwent ligationTreatment modalitiesFemoral arteryIliac arteryCardiovascular diseaseT cellsVEGF administrationAngiopoietin-2Thigh incision