2024
Adverse Food Reactions: Physiological and Ecological Perspectives
Korn L, Kutyavin V, Bachtel N, Medzhitov R. Adverse Food Reactions: Physiological and Ecological Perspectives. Annual Review Of Nutrition 2024, 44: 155-178. PMID: 38724028, DOI: 10.1146/annurev-nutr-061021-022909.Peer-Reviewed Original ResearchEvolutionary Medicine
Stearns S, Medzhitov R. Evolutionary Medicine. 2024 DOI: 10.1093/oso/9780192871978.001.0001.Peer-Reviewed Original ResearchRisk of metastasisPlacental invasionSolid tumorsEvolution of reproductionMental disordersAdaptive therapyPublic healthVaccine developmentEvolution of agingSick personEvolutionary historyEvolutionary insightsPhage therapyPathogen emergenceIndependent evolutionEvolutionary hypothesesHealthEvolutionary aspectsTherapyCancerDiseaseEvolutionary medicineMedical researchChildbirthMacrophages restrain pathological interferon responses during viral respiratory infection
Rodriguez-Morales P, Hoagland D, Mann A, Yu S, Lai A, Baez Vazquez A, Medzhitov R, Franklin R. Macrophages restrain pathological interferon responses during viral respiratory infection. The Journal Of Immunology 2024, 212: 0536_5144-0536_5144. DOI: 10.4049/jimmunol.212.supp.0536.5144.Peer-Reviewed Original ResearchIFN-I productionOncostatin MBlockade of IFN-I signalingViral stimuliEpithelial cellsIFN-IOSM-deficient miceViral respiratory infectionsTriggered by infectionInflammation-induced pathologyLung epithelial cellsIFN-I responseIFN-I signalingRegulation of inflammationType I interferonPoly(I:CAcute blockadeCytokine oncostatin MRespiratory infectionsUncontrolled inflammationInflammatory responseI interferonInterferon responseRespiratory tractMiceProteostasis maintenance by macrophage trogocytosis
Kimura Y, Philip N, Chavan A, Medzhitov R. Proteostasis maintenance by macrophage trogocytosis. The Journal Of Immunology 2024, 212: 1318_4183-1318_4183. DOI: 10.4049/jimmunol.212.supp.1318.4183.Peer-Reviewed Original ResearchStressed cellsProtein aggregationCellular fitnessMaintenance of cellular fitnessEndoplasmic reticulum stress response pathwayMembrane-associated isoformStress response pathwaysProtein degradation pathwaysDNA repair programsCellular stress responseRemoval of protein aggregatesProtein aggregate accumulationProteostasis maintenanceChaperone inductionHomeostasis in vivoProtein misfoldingResponse pathwaysAbstract CellsCell-to-cell interactionsProteostasisStress responseDNA damageTransferred to macrophagesAggregate accumulationProteinExploring new perspectives in immunology
Medzhitov R, Iwasaki A. Exploring new perspectives in immunology. Cell 2024, 187: 2079-2094. PMID: 38670066, DOI: 10.1016/j.cell.2024.03.038.Peer-Reviewed Original ResearchMechanosensing regulates tissue repair program in macrophages
Meizlish M, Kimura Y, Pope S, Matta R, Kim C, Philip N, Meyaard L, Gonzalez A, Medzhitov R. Mechanosensing regulates tissue repair program in macrophages. Science Advances 2024, 10: eadk6906. PMID: 38478620, PMCID: PMC10936955, DOI: 10.1126/sciadv.adk6906.Peer-Reviewed Original ResearchConceptsExtracellular matrixRegulate chromatin accessibilityTissue repair programGene expression programsCytoskeletal dynamicsChromatin accessibilityAmoeboid migrationCytoskeletal remodelingBiochemical signalsTissue homeostasisExpression programsColony-stimulating factor-1Tissue-resident macrophagesFactor 1MechanosensingRegulating tissue repairTissue integrityMacrophagesTissueThree-dimensional environmentRepair programHomeostasisNutrient-derived signals regulate eosinophil adaptation to the small intestine
Kutyavin V, Korn L, Medzhitov R. Nutrient-derived signals regulate eosinophil adaptation to the small intestine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2316446121. PMID: 38271336, PMCID: PMC10835075, DOI: 10.1073/pnas.2316446121.Peer-Reviewed Original ResearchConceptsRetinoic acid signalingCrypt-villus axisLocalization signalTissue-specific adaptationsAcid signalingAmino acidsFunctional significanceTranscriptional signatureHomeostatic conditionsSmall intestineTissue microenvironmentType 2 immunityPurified amino acidsSignalAccumulationEffector cellsBone marrowIL-5Eosinophil accumulationSubpopulationsIntestineEffectorAdaptationHigh-protein diet
2023
Characterization of behavioral avoidance to a food allergen in different strains of mice
Lima B, Cullen J, de Paula Carvalho L, Bober J, Florsheim E, Medzhitov R, Dietrich M. Characterization of behavioral avoidance to a food allergen in different strains of mice. Brain Behavior And Immunity 2023, 114: 71. DOI: 10.1016/j.bbi.2024.01.204.Peer-Reviewed Original Research
2006
Role of Toll-like Receptors in Commensal Dependent Colitis
Rakoff-Nahoum S, Medzhitov R. Role of Toll-like Receptors in Commensal Dependent Colitis. Inflammatory Bowel Diseases 2006, 12: s3-s3. DOI: 10.1097/0054725-200604002-00010.Peer-Reviewed Original Research