2023
A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures
Kuhn R, Barrett A, Desilva A, Harris E, Kramer L, Montgomery R, Pierson T, Sette A, Diamond M. A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures. The Journal Of Infectious Diseases 2023, 228: s398-s413. PMID: 37849402, PMCID: PMC10582523, DOI: 10.1093/infdis/jiad193.Peer-Reviewed Original ResearchConceptsFamily of positive-strand RNA virusesPositive-strand RNA virusesSelf-limited febrile syndromeSpread of flavivirusesRNA virusesPrototype flavivirusDevelopment of vaccinesFebrile syndromePandemic potentialYellow fever virusFlaviviridae familyHuman infectionsViscerotropic diseaseZika virusTick vectorFever virusFlavivirusesDengue virusVaccineVirusGenus
2008
RNA interference screen for human genes associated with West Nile virus infection
Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E. RNA interference screen for human genes associated with West Nile virus infection. Nature 2008, 455: 242-245. PMID: 18690214, PMCID: PMC3136529, DOI: 10.1038/nature07207.Peer-Reviewed Original ResearchMeSH KeywordsComputational BiologyDengue VirusEndoplasmic ReticulumGene Expression ProfilingGenome, HumanHeLa CellsHIVHumansImmunityMonocarboxylic Acid TransportersMuscle ProteinsProtein BindingRNA InterferenceUbiquitinationUbiquitin-Protein LigasesVesiculovirusVirus ReplicationWest Nile FeverWest Nile virusWest Nile Virus Attenuates Activation of Primary Human Macrophages
Kong KF, Wang X, Anderson JF, Fikrig E, Montgomery RR. West Nile Virus Attenuates Activation of Primary Human Macrophages. Viral Immunology 2008, 21: 78-82. PMID: 18355125, PMCID: PMC2666911, DOI: 10.1089/vim.2007.0072.Peer-Reviewed Original ResearchConceptsWest Nile virusPrimary human macrophagesHuman macrophagesWNV infectionProduction of interleukinMosquito-borne flavivirusType I interferonProinflammatory cytokinesPotent therapyJAK/STAT pathwayIL-1betaEffective treatmentMacrophage activationI interferonRelated flavivirusesInfectionAttenuate activationNile virusMacrophagesSTAT pathwayFlavivirusesActivationDifferential responseInterleukinCytokines