2015
An endothelial TLR4‐VEGFR2 pathway mediates lung protection against oxidant‐induced injury
Takyar S, Zhang Y, Haslip M, Jin L, Shan P, Zhang X, Lee PJ. An endothelial TLR4‐VEGFR2 pathway mediates lung protection against oxidant‐induced injury. The FASEB Journal 2015, 30: 1317-1327. PMID: 26655705, PMCID: PMC4750407, DOI: 10.1096/fj.15-275024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisEndothelial CellsHydrogen PeroxideHyperoxiaLungLung InjuryMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, TransgenicOxidantsOxygenProto-Oncogene Proteins c-aktSignal TransductionToll-Like Receptor 4Vascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2ConceptsVEGF receptor 2Primary endothelial cellsLung protectionEndothelial cellsC57/BL6 miceEffect of TLR4VEGF transgenic miceRole of TLR4Bone marrow chimerasLung cell apoptosisTLR4 knockdownTLR4 deficiencyLung injuryTLR4 expressionBL6 miceProtective effectLung compartmentsReceptor 2TLR4Transgenic miceHuman TLR4LDH releaseTransgenic modelingCell apoptosisInjury
2011
RIG-like Helicase Innate Immunity Inhibits Vascular Endothelial Growth Factor Tissue Responses via a Type I IFN–dependent Mechanism
Ma B, Dela Cruz CS, Hartl D, Kang MJ, Takyar S, Homer RJ, Lee CG, Elias JA. RIG-like Helicase Innate Immunity Inhibits Vascular Endothelial Growth Factor Tissue Responses via a Type I IFN–dependent Mechanism. American Journal Of Respiratory And Critical Care Medicine 2011, 183: 1322-1335. PMID: 21278304, PMCID: PMC3114061, DOI: 10.1164/rccm.201008-1276oc.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDEAD Box Protein 58DEAD-box RNA HelicasesDisease Models, AnimalEdemaFocal Adhesion Protein-Tyrosine KinasesImmunity, InnateInflammationInterferon Type IMiceMice, TransgenicMitogen-Activated Protein KinasesNitric Oxide Synthase Type IIIPhosphatidylinositol 3-KinasePoly I-CPulmonary Disease, Chronic ObstructiveToll-Like Receptor 3Vascular Endothelial Growth Factor AConceptsVascular endothelial growth factorType 2 inflammationChronic obstructive pulmonary disease exacerbationsObstructive pulmonary disease exacerbationsChronic obstructive pulmonary diseaseViral pathogen-associated molecular patternsEndothelial nitric oxide synthaseRIG-like helicasePulmonary disease exacerbationsObstructive pulmonary diseasePathogenesis of asthmaRespiratory syncytial virusNormal pulmonary physiologyNitric oxide synthaseAntiviral innate immunityPathogen-associated molecular patternsReceptor-dependent pathwayTissue responseEndothelial growth factorVEGF receptor 1Ability of VEGFDisease exacerbationPulmonary diseaseRespiratory virusesControl mice