2024
cnnImpute: missing value recovery for single cell RNA sequencing data
Zhang W, Huckaby B, Talburt J, Weissman S, Yang M. cnnImpute: missing value recovery for single cell RNA sequencing data. Scientific Reports 2024, 14: 3946. PMID: 38365936, PMCID: PMC10873334, DOI: 10.1038/s41598-024-53998-x.Peer-Reviewed Original ResearchMeSH KeywordsCluster AnalysisExome SequencingGene Expression ProfilingProbabilityRNASequence Analysis, RNASingle-Cell AnalysisConceptsScRNA-seqAdvent of single-cell RNA sequencingScRNA-seq data analysisSingle cell RNA sequencing dataSingle-cell RNA sequencingRNA sequencing dataConvolutional neural networkSequence dataRNA sequencingCellular diversityExpression valuesCNN-based modelsMissing valuesCell clustersNeural networkIntricate diseaseIssue of missing dataSuperior performanceMissing probabilitySequenceBenchmark experimentsDiversityData analysisExpression
2005
Two types of precursor cells in a multipotential hematopoietic cell line
Ye ZJ, Kluger Y, Lian Z, Weissman SM. Two types of precursor cells in a multipotential hematopoietic cell line. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 18461-18466. PMID: 16352715, PMCID: PMC1317970, DOI: 10.1073/pnas.0509314102.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD34Cell DifferentiationCell LineGene Expression ProfilingGene Expression RegulationGlobinsHematopoietic Stem CellsMiceMultipotent Stem CellsOligonucleotide Array Sequence AnalysisPhosphorylationProtein BindingProto-Oncogene Proteins c-kitReceptors, Interleukin-3Transcription FactorsConceptsMultipotential hematopoietic cell linePrecursor cellsBeta-globin transcriptionCell linesMultipotential cell lineLocus control region hypersensitive site-2CD34- populationHypersensitive site 2Hematopoietic cell linesStem cell factor receptorPresence of SCFHematopoietic differentiationCell factor receptorDevelopmental transitionsNormal developmental transitionsCytokines IL-3Growth responseCell surface markersFactor receptorIL-3Mixed populationSite 2CellsSurface markersDifferent roles