2024
cnnImpute: missing value recovery for single cell RNA sequencing data
Zhang W, Huckaby B, Talburt J, Weissman S, Yang M. cnnImpute: missing value recovery for single cell RNA sequencing data. Scientific Reports 2024, 14: 3946. PMID: 38365936, PMCID: PMC10873334, DOI: 10.1038/s41598-024-53998-x.Peer-Reviewed Original ResearchConceptsScRNA-seqAdvent of single-cell RNA sequencingScRNA-seq data analysisSingle cell RNA sequencing dataSingle-cell RNA sequencingRNA sequencing dataConvolutional neural networkSequence dataRNA sequencingCellular diversityExpression valuesCNN-based modelsMissing valuesCell clustersNeural networkIntricate diseaseIssue of missing dataSuperior performanceMissing probabilitySequenceBenchmark experimentsDiversityData analysisExpression
2005
Two types of precursor cells in a multipotential hematopoietic cell line
Ye ZJ, Kluger Y, Lian Z, Weissman SM. Two types of precursor cells in a multipotential hematopoietic cell line. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 18461-18466. PMID: 16352715, PMCID: PMC1317970, DOI: 10.1073/pnas.0509314102.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD34Cell DifferentiationCell LineGene Expression ProfilingGene Expression RegulationGlobinsHematopoietic Stem CellsMiceMultipotent Stem CellsOligonucleotide Array Sequence AnalysisPhosphorylationProtein BindingProto-Oncogene Proteins c-kitReceptors, Interleukin-3Transcription FactorsConceptsMultipotential hematopoietic cell linePrecursor cellsBeta-globin transcriptionCell linesMultipotential cell lineLocus control region hypersensitive site-2CD34- populationHypersensitive site 2Hematopoietic cell linesStem cell factor receptorPresence of SCFHematopoietic differentiationCell factor receptorDevelopmental transitionsNormal developmental transitionsCytokines IL-3Growth responseCell surface markersFactor receptorIL-3Mixed populationSite 2CellsSurface markersDifferent rolesWerner Protein Protects Nonproliferating Cells from Oxidative DNA Damage
Szekely AM, Bleichert F, Nümann A, Van Komen S, Manasanch E, Nasr A, Canaan A, Weissman SM. Werner Protein Protects Nonproliferating Cells from Oxidative DNA Damage. Molecular And Cellular Biology 2005, 25: 10492-10506. PMID: 16287861, PMCID: PMC1291253, DOI: 10.1128/mcb.25.23.10492-10506.2005.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphatasesCell ProliferationCells, CulturedCellular SenescenceDNADNA DamageDNA HelicasesDNA ReplicationExodeoxyribonucleasesFibroblastsGene Expression RegulationHumansOxidation-ReductionOxidative StressOxygenRecQ HelicasesRNA InterferenceTelomeric Repeat Binding Protein 2Werner Syndrome HelicaseConceptsDNA damage responseWerner syndromeDamage responseDNA damageRNA interferenceOxidative DNA damageWRN-depleted cellsInduction of gammaH2AXDNA damage fociCellular senescence phenotypePrimary human fibroblastsWRN depletionWerner proteinWRN proteinNuclear fociWRN deficiencyProtein TRF2Telomere maintenanceAcute oxidative stressBLM expressionDNA homeostasisDNA replicationDamage fociSenescence phenotypePhysiological oxygen
1995
A simplified approach for isolating oligo(dT) primed cDNA clones with probes generated by cDNA selection
Xu H, Wei H, Kolluri R, Weissman S. A simplified approach for isolating oligo(dT) primed cDNA clones with probes generated by cDNA selection. Nucleic Acids Research 1995, 23: 4528-4529. PMID: 7501482, PMCID: PMC307416, DOI: 10.1093/nar/23.21.4528.Peer-Reviewed Original Research
1990
Transcription Analysis, Physical Mapping, and Molecular Characterization of a Nonclassical Human Leukocyte Antigen Class I Gene
Chorney M, Ada I, Gillespie G, Srivastava R, Pan J, Weissman S. Transcription Analysis, Physical Mapping, and Molecular Characterization of a Nonclassical Human Leukocyte Antigen Class I Gene. Molecular And Cellular Biology 1990, 10: 243-253. DOI: 10.1128/mcb.10.1.243-253.1990.Peer-Reviewed Original ResearchHLA-HClass I genesIntron 3I genePortion of intron 3Regions of sequence divergenceExon 4Class I cDNA clonesL cellsTranslation termination codonSingle-base deletionHuman major histocompatibility complexMouse L cellsSequence divergenceCDNA clonesPhysical mapTranscribed portionPolyadenylated RNATranscription sitesTermination codonPromoter sequencesSplice sequencesHla transcriptionGene fragmentsStable transcripts
1985
Synthesis of Predominantly Unspliced Cytoplasmic RNAs by Chimeric Herpes Simplex Virus Type 1 Thymidine Kinase-Human β-Globin Genes
Greenspan D, Weissman S. Synthesis of Predominantly Unspliced Cytoplasmic RNAs by Chimeric Herpes Simplex Virus Type 1 Thymidine Kinase-Human β-Globin Genes. Molecular And Cellular Biology 1985, 5: 1894-1900. DOI: 10.1128/mcb.5.8.1894-1900.1985.Peer-Reviewed Original Research